Dietary cytidine (5′)-diphosphocholine supplementation protects against development of memory deficits in aging rats
Abstract
The present study was designed to assess the effect of supplementation with dietary cytidine (5')-diphosphocholine (CDP-choline), a source of cytidine and choline, on memory in young and older rats. Although the hippocampal-dependent memory deficits in aged rats are well documented, cognitive functioning in early aging has not been as thoroughly evaluated. Female Sprague-Dawley rats (3 or 15 months of age) consumed either a control diet or a diet supplemented with CDP-choline (approximately 500 mg/kg/day) for 8 weeks, after which they were trained to perform spatial and cued versions of the Morris water maze. Compared with young rats, aged rats exhibited a selective deficit in spatial memory tasks that required rats to retain information for 24 h or longer. CDP-choline supplementation protected against the development of this deficit, but had no memory-enhancing effect in normal young rats. These findings suggest that early-aged rats display a selective impairment in hippocampal-dependent long-term memory, and that dietary CDP-choline supplementation can protect against this deficit.
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Studies have shown benefits of dietary choline intake and supplementation on cognitive performance in human individuals and in animal models.
“This finding aligns with studies showing benefits of dietary choline intake and supplementation on cognitive performance in human individuals and in animal models71–78.”
From Single-cell multiregion dissection of Alzheimer’s disease (2024) · cites this paper as [71]
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Hirsch, M. J., Growdon, J. H., & Wurtman, R. J. (1978) · Metabolism · doi:10.1016/0026-0495(78)90139-7 · Cited by 95 · see citing works
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Isgor, C., Kabbaj, M., Akil, H., & Watson, S. J. (2004) · Hippocampus · doi:10.1002/hipo.10207 · Cited by 341 · see citing works
Single-cell multiregion dissection of Alzheimer’s disease
Mathys, H., Boix, C. A., Akay, L. A., Xia, Z., Davila-Velderrain, J., Ng, A. P., Jiang, X., Abdelhady, G., Galani, K., Mantero, J., et al. (2024) · Nature · doi:10.1038/s41586-024-07606-7 · Cited by 343 · see citing works
Wurtman, R. J., Ulus, I. H., Cansev, M., Watkins, C. J., Wang, L., & Marzloff, G. (2006) · Brain Research · doi:10.1016/j.brainres.2006.03.019 · Cited by 169 · see citing works
Self-citationAcupuncture improved cognitive impairment caused by multi-infarct dementia in rats
YU, J., LIU, C., ZHANG, X., & HAN, J. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.07.015 · Cited by 85 · see citing works
Alvarenga, A. B., Oliveira, H. R., Turner, S. P., Garcia, A., Retallick, K. J., Miller, S. P., & Brito, L. F. (2023) · Genetics Selection Evolution · doi:10.1186/s12711-023-00777-3 · Cited by 18 · see citing works
- Authors
- Teather, L. A., & Wurtman, R. J.
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 27
- Issue
- 4
- Pages
- 711-717
- ISSN
- 0278-5846
- Cited by
- 44
- References
- 1
- Language
- en
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