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Cited by 341Stress Responses and CortisolMemory and Neural MechanismsNeurogenesis and neuroplasticity mechanisms

Delayed effects of chronic variable stress during peripubertal‐juvenile period on hippocampal morphology and on cognitive and stress axis functions in rats

Isgor, Ceylan, Kabbaj, Mohamed, Akil, Huda, Watson, Stanley J.·2004·Hippocampus
DOI 10.1002/hipo.10207
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Abstract

Animal studies on the effects of chronic variable stress during the peripubertal‐juvenile period on hippocampal structure and function are lacking. Twenty‐eight‐day‐old Sprague‐Dawley rats were subjected to random, variable physical or social stress regimens for 4 weeks. Hippocampal volume was found to continue to grow in all lamina examined during the transition into young adulthood. Our variable physical stress paradigm led to inhibition of this growth in the CA1 pyramidal cell layer (PCL) and in the dentate gyrus‐granular cell layer (DG‐GCL), which reached full arrest in the CA3‐PCL. Volume deficits were first observed after chronic stress exposure when 3 weeks, but not 24 h, of recovery had elapsed. Moreover, these volume deficits were associated with impairments in the Morris water‐maze navigation, sustained downregulation in the basal hippocampal glucocorticoid receptor gene expression, and deficits in the shutdown of acute stress‐induced corticosterone secretion. Volume changes both due to normal maturation and after chronic stress exposure were independent of neuron number. Thus, a peripubertal‐juvenile chronic stress paradigm that leads to significant alterations in the limbic‐hypothalamic‐pituitary‐adrenal axis can produce robust effects in hippocampal structure and cognitive ability, lasting into adulthood. © 2004 Wiley‐Liss, Inc.

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  • There is contradictory information concerning whether chronic restraint stress reduces BDNF mRNA levels, with some studies reporting a decrease and others reporting no change.

    “However, there is contradictory information thus far concerning whether CRS reduces BDNF mRNA levels, some reporting a decrease79 and other studies reporting no change.80,81”

    From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [81]

  • Prenatal stress impairs hippocampal development in rats, as does stress in adolescence.

    “Prenatal stress impairs hippocampal development in rats, as does stress in adolescence.”

    From Neurobiological and Systemic Effects of Chronic Stress (2017) · cites this paper as [85]

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Authors
Isgor, C., Kabbaj, M., Akil, H., & Watson, S. J.
Affiliations
  • University of Michigan (US)
  • Florida State University (US)
Corresponding author
Isgor, Ceylan
ORCID
Venue
Hippocampus
Publisher
Wiley
Published
2004-01
Volume
14
Issue
5
Pages
636-648
ISSN
  • 1050-9631 (ISSN-L)
  • 1098-1063
DOI
10.1002/hipo.10207
OpenAlex
W2054980594
Cited by
341
References
49
Citations by year
2026: 7 · 2025: 5 · 2024: 5 · 2023: 9 · 2022: 17 · 2021: 17 · 2020: 13 · 2019: 20 · 2018: 20 · 2017: 17 · 2016: 25 · 2015: 16 · 2014: 35 · 2013: 22 · 2012: 21
FWCI
2.96
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 60 d)
Locations
  • Hippocampus (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01da002265-19)
  • National Institute on Drug Abuse (DA 04294, DA02265)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
chronic variable stress, hippocampal morphology, hippocampal volume, hippocampal maturation, dentate gyrus, corticosterone secretion, hypothalamic-pituitary-adrenal axis, stress-induced cognitive impairment, social stress, physical stress, stress recovery, rats
MeSH terms
Age Factors, Animals, Atrophy, Cell Differentiation, Chronic Disease, Corticosterone, Disease Models, Animal, Hippocampus, Hypothalamo-Hypophyseal System, Male, Memory Disorders, Neuronal Plasticity, Pituitary-Adrenal System, Reaction Time, Receptors, Glucocorticoid, RNA, Messenger, Stress, Physiological, Stress, Psychological, Down-Regulation, Rats, Sprague-Dawley, Maze Learning, Rats

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