The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Biological reactivity and biomarkers of the neutrophil oxidant, hypochlorous acid
Abstract
Free radicals or reactive oxygen species are thought to contribute to the pathology of many diseases. These include inflammatory conditions, where neutrophils accumulate in large numbers and are stimulated to produce superoxide and other reactive oxidants. Hypochlorous acid (HOCl), produced by myeloperoxidase-catalysed oxidation of chloride by hydrogen peroxide, is the major strong oxidant generated by these cells. Neutrophil-mediated injury may also be important in toxicology when an initial insult is followed by an inflammatory response. It is important to characterize the inflammatory component of such injury and the extent to which it involves reactive oxidants. On the one hand, this requires an understanding of how neutrophil oxidants react with cells and tissue constituents. On the other, specific biomarkers are needed so that oxidative damage can be quantified in clinical material and related to disease severity. This presentation considers biologically relevant reactions of HOCl and the biomarker assays that can be applied to probing the pathological role of myeloperoxidase and its products.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These inhibitors do not have a noticeable effect on XO- or eNOS-dependent ROS production, so they can be considered specific pan-NOX inhibitors.”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [1016]
Citations
Cites
Inflammation. Basic principles and clinical correlates
(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90156-x · Cited by 2,388
Hazen, S. L., & Heinecke, J. W. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119379 · Cited by 842
Protein Carbonyl Measurement by a Sensitive ELISA Method
Buss, H., Chan, T., Sluis, K. B., Domigan, N. M., & Winterbourn, C. C. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00104-4 · Cited by 687
Self-citationInflammation: Basic Principles and Clinical Correlates
Ehrlich, G. E. (2000) · JAMA · doi:10.1001/jama.283.1.123 · Cited by 621
Presence of hypochlorite-modified proteins in human atherosclerotic lesions.
Hazell, L. J., Arnold, L., Flowers, D., Waeg, G., Malle, E., & Stocker, R. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118576 · Cited by 592
Winterbourn, C. C. (1985) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(85)90120-5 · Cited by 463
Self-citationPeskin, A. V., & Winterbourn, C. C. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00506-2 · Cited by 335
Self-citationChlorination of Tyrosyl Residues in Peptides by Myeloperoxidase and Human Neutrophils
Domigan, N. M., Charlton, T. S., Duncan, M. W., Winterbourn, C. C., & Kettle, A. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.28.16542 · Cited by 330
Self-citationHazell, L. J., van den Berg, J. J. M., & Stocker, R. (1994) · Biochemical Journal · doi:10.1042/bj3020297 · Cited by 267
Chlorohydrin Formation From Unsaturated Fatty Acids Reacted With Hypochlorous Acid
Winterbourn, C. C., van den Berg, J. J. M., Roitman, E., & Kuypers, F. A. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90609-z · Cited by 258
Self-citation
Cited by
Sorted by citations
Items 201–247 of 247
Yamaji, K., Taniguchi, R., Urano, H., & Ogasawara, H. (2023) · FEBS Letters · doi:10.1002/1873-3468.14574 · Cited by 6
Christopher, T. B., Mahamat, O., Chungong, M. N., Ngwa, C. A., & Samka, P. M. (2020) · Journal of Medicinal Food · doi:10.1089/jmf.2020.0005 · Cited by 6
Lipofundin 20% induces hyperlipidemia and oxidative stress in male Sprague Dawley rats
Delgado-Roche, L., FragaPerez, F., BequerViart, M., & Hernández-Matos, Y. (2011) · Veterinary World · doi:10.5455/vetworld.2012.133-137 · Cited by 5
Szala, M., Grzelakowska, A., Michalski, R., Dębowska, K., Modrzejewska, J., Adamczyk, M., Siarkiewicz, P., Sikora, A., Zielonka, J., & Podsiadły, R. (2023) · Dyes and Pigments · doi:10.1016/j.dyepig.2023.111888 · Cited by 5
Morabito, F., Tomaino, A., Cristani, M., Cimino, F., Martino, M. V., Minciullo, P. L., Calabrò, C., Saija, A., & Gangemi, S. (2005) · Transfusion and Apheresis Science · doi:10.1016/j.transci.2005.05.003 · Cited by 5
Mouithys-Mickalad, A. A., Storms, N., Franck, T. J., Ceusters, J. D., de Pouyade, G. D. L. R., Deby-Dupont, G. P., & Serteyn, D. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.677675 · Cited by 5
Germicide wound pad with active, in situ, electrolytically produced hypochlorous acid
Rubinsky, L., Patrick, B. A., Mikus, P., & Rubinsky, B. (2016) · Biomedical Microdevices · doi:10.1007/s10544-016-0052-4 · Cited by 5
Mosca, A., CASALE, A. D., Borro, M., Gentile, G., Pomes, L. M., Padovano, A., Fiaschè, F., Pinzone, V., Rapinesi, C., Zoppi, T., et al. (2021) · Personalized Medicine · doi:10.2217/pme-2019-0141 · Cited by 5
Hartsema, E. A., Hemmling, H., & Hawkins, C. L. (2025) · Advances in Redox Research · doi:10.1016/j.arres.2025.100119 · Cited by 4
Chancharoen, M., Yang, Z., Dalvie, E. D., Gubina, N., Ruchirawat, M., Croy, R. G., Fedeles, B. I., & Essigmann, J. M. (2024) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.3c00358 · Cited by 4
Liver injury and abscess formation in secondary murine peritonitis
Lenz, A. M., Fairweather, M., Peyton, J. C., Gardner, S. A., & Cheadle, W. G. (2010) · Inflammation Research · doi:10.1007/s00011-010-0273-6 · Cited by 4
Denys, G. A., Davis, J. C., O'Hanley, P. D., & Stephens, J. T. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01606-10 · Cited by 4
Aydın, S. (2005) · Biochemistry (Moscow) · doi:10.1007/s10541-005-0271-4 · Cited by 4
Double-mode detection of HClO by naked eye and concurrent fluorescence increasing in absolute PBS
Wang, B., Wen, J., Gao, K., Yan, H., Xu, Y., Li, H., Chen, M., Wang, W., & Sun, S. (2016) · RSC Advances · doi:10.1039/c6ra03959f · Cited by 4
Myeloperoxidase in vascular disease and autoimmunity
Astern, J. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/shh2-9b27 · Cited by 4
NADPH Oxidases: Structure and Function
Quinn, M. T. (2013) · Wiley eBooks · doi:10.1002/9781118355886.ch7 · Cited by 3
Yang, L. L., Jiang, Y., Sun, A., Chen, M., Li, Q., Wang, P., & Zhang, J. (2024) · RSC Advances · doi:10.1039/d4ra03433c · Cited by 3
Combating Parasites: Immune Response and Inflammation
Costantini, D. (2014) · Springer eBooks · doi:10.1007/978-3-642-54663-1_8 · Cited by 3
Liu, H., Tonoyan, L., Reiz, B., & Siraki, A. G. (2025) · Redox Biochemistry and Chemistry · doi:10.1016/j.rbc.2025.100051 · Cited by 3
Lighting up halogens: organic fluorescent probes for environmental sensing and bioimaging
Xu, J., Zhang, M., Wang, J., Zhang, S., Wang, X., & Gao, M. (2026) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2026.217734 · Cited by 2
Koczurowska, A., Carrillo, D. R., García-Alai, M., Zakłos‐Szyda, M., Bujacz, G., & Pietrzyk‐Brzezinska, A. J. (2024) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2024.110269 · Cited by 2
Zareen, W., Ahmed, N., Ismail, M. A., Feroz, H., Khan, M. A., Shafiq, Z., & Gomha, S. M. (2025) · RSC Advances · doi:10.1039/d5ra06003f · Cited by 2
Matsuura, H. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815409-0.00009-7 · Cited by 1
N-Acetyl-5-chloro-3-nitro- L -tyrosine ethyl ester
Mutahi, T. T., Edagwa, B., Fronczek, F. R., & Uppu, R. M. (2012) · Acta Crystallographica Section E Structure Reports Online · doi:10.1107/s1600536812036380 · Cited by 1
The Neutrophil Respiratory Burst Oxidase
Quinn, M. T. (2013) · IMPERIAL COLLEGE PRESS eBooks · doi:10.1142/9781848168374_0002 · Cited by 1
ICS Medal and Research Abstract Presentations
(2011) · Journal of the Intensive Care Society · doi:10.1177/175114371101200117 · Cited by 1
Glew, L. (2013) · PEARL (University of Plymouth) · doi:10.24382/1845
Animal Models and Oxidative Biomarkers to Evaluate Preclinical Safety of Extracellular Hemoglobins
Buehler, P. W., & D’Agnillo, F. (2011) · Wiley eBooks · doi:10.1002/9781119975427.ch28
Asepsie-antisepsie en endodontie
Pérard, M., Clerc, J. L., Gautier, T., Pérez, F., Vulcain, J.-M., Dautel-Morazin, A., & Goff, A. L. (2014)
Apoptotic neutrophils enhance the immune response against Mycobacterium tuberculosis
Persson, A. (2009) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Elia, M. (2011)
Oxidative Stress in Depression 103
Gaøecki, P. (2014)
The Role Of Thiocyanate In Modulating Tissue Damage In Cardiovascular Disease
Hall, L. (2017) · The Sydney eScholarship Repository (The University of Sydney)
The Role of DNA Damage and Extracellular Trap Formation in Atherosclerosis
Tang, V. (2020) · UTS ePRESS (University of Technology Sydney)
ФЛУОРЕСЦЕНТНЫЕ ЗОНДЫ ДЛЯ ОБНАРУЖЕНИЯ ХЛОРНОВАТИСТОЙ КИСЛОТЫ В ЖИВЫХ КЛЕТКАХ
Реут, В. Е., Горудко, И. В., Григорьева, Д. В., Соколов, А. В., & Панасенко, О. М. (2022) · Биоорганическая химия · doi:10.31857/s0132342322030162
Palencia, F. C. D. D., Díaz, M. G., Hissi, E. G. V., Gomez-Mejiba, S., Ramírez, D. C., & Martínez, J. C. G. (2024) · ChemistrySelect · doi:10.1002/slct.202303359
Yang, L. L., Jiang, Y., Sun, A., Chen, M., & Wang, P. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4783243
Costantini, D. (2024) · Fascinating life sciences · doi:10.1007/978-3-031-65183-0_2
The Impact of Low-Level Laser Irradiation on the Activity of Alpha-Amylase
Musawi, M. S. A. (2025) · Photonics · doi:10.3390/photonics12080774
Targeting a specific subset of neutrophils to mitigate cardiac reperfusion injuryPreprint
Singh, A., Stuart, A., Chakraborty, S., Malik, A. B., & Bachmaier, K. (2025) · Research Square · doi:10.21203/rs.3.rs-8273505/v1
Chen, S., Pan, J., Gong, Z., Wu, M., Zhang, X., Chen, H., Yang, D., Qi, S., Peng, Y., & Shen, J. (2024) · Figshare · doi:10.6084/m9.figshare.26696511
Jia, Q., Fu, Y., Bai, M., Xu, X., Zhong, Y., Yan, H., Feng, Y., Jia, Y., Zhang, R., Wang, Z., et al. (2026) · Acta Biomaterialia · doi:10.1016/j.actbio.2026.01.047
Propriétés anti-oxydants, anti-inflammatoires et antispasmodiques d’Ocimum basilicum
Bensaid, A. (2022) · theses.fr (ABES) · doi:10.70675/3f2752bfzd83cz4296zb2c8z16170cc69251
Gulati, P., Taneja, S., Selvam, P., Ramasamy, S. K., & Kumar, S. K. A. (2026) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2026.146332
Liang, L., Li, B., Jin, Z., Hu, T., Wei, T., & Niu, Q. (2026) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2026.128600
Metadata
- Authors
- Winterbourn, C. C.
- Corresponding author
- Winterbourn, Christine C.
- Venue
- Toxicology
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 181-182
- Pages
- 223-227
- ISSN
- 0300-483X (ISSN-L)
- OpenAlex
- W2065076024
- Cited by
- 247
- References
- 26
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 17 · 2023: 9 · 2022: 11 · 2021: 13 · 2020: 15 · 2019: 10 · 2018: 12 · 2017: 9 · 2016: 10 · 2015: 9 · 2014: 16 · 2013: 19 · 2012: 13
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- hypochlorous acid, neutrophils, myeloperoxidase, reactive oxygen species, oxidative stress, biomarkers, oxidative damage, inflammation, neutrophil-mediated injury, superoxide, hydrogen peroxide, biomarker assays
- MeSH terms
- Animals, Chlorohydrins, Humans, Hypochlorous Acid, Neutrophils, Oxidation-Reduction, Proteins, Sulfhydryl Compounds, Tyrosine, Biomarkers, Oxidants
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review