Cited by 65Genomics and Chromatin DynamicsChromatin Remodeling and CancerNuclear Structure and Function

Chromatin structure and dynamics: Functional implications

Morales, Violette, Giamarchi, Claire, Chailleux, Catherine, Moro, Françoise, Marsaud, Véronique, Le Ricousse, Sophie, Richard-Foy, Hélène·2001·Biochimie

Abstract

In eucaryotes, DNA packaging into nucleosomes and its organization in a chromatin fiber generate constraints for all processes involving DNA, such as DNA-replication, -repair, -recombination, and -transcription. Transient changes in chromatin structure allow overcoming these constraints with different requirements in regions where processes described above are initiated. Mechanisms involved in chromatin dynamics are complex. Multiprotein complexes which can contain histone-acetyltransferase, -deacetylase, -methyltransferase or -kinase activities are targeted by regulatory factors to precise regions of the genome. These enzymes have been shown to modify histone-tails within specific nucleosomes. Post-translational modifications of histone-tails constitute a code that is thought to contribute to the nucleosome or to the chromatin fiber remodeling, either directly, or through the recruitment of other proteins. Other multiprotein complexes, such as ATP-dependent remodeling complexes, play an essential role in chromatin fiber dynamics allowing nucleosome sliding and redistribution on the DNA. We will focus here on the chromatin structure and its consequences for DNA damaging, replication, repair, and transcription and we will discuss the mechanisms of chromatin remodeling.

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Crossref · 10.1016/s0300-9084(01)01347-5

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Authors
Morales, V., Giamarchi, C., Chailleux, C., Moro, F., Marsaud, V., Le Ricousse, S., & Richard-Foy, H.
Affiliations
Centre National de la Recherche Scientifique (FR)
Venue
Biochimie
Publisher
Elsevier BV
Published
2001-11
Volume
83
Issue
11-12
Pages
1029-1039
ISSN
  • 0037-9042 (ISSN-L)
  • 0300-9084
OpenAlex
W1966921819
Cited by
65
References
56
Citations by year
2026: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 7 · 2019: 1 · 2018: 1 · 2017: 2 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 4
FWCI
0.30
Type
journal article
Language
en
Open access
closed
Locations
  • Biochimie (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords
chromatin structure, chromatin dynamics, nucleosome, chromatin fiber, histone modifications, histone acetylation, histone deacetylation, histone methylation, histone kinase, chromatin remodeling, DNA replication, DNA repair, DNA recombination, transcription, DNA damage
MeSH terms
Acetyltransferases, Animals, Chromatin, DNA Damage, DNA Repair, DNA Replication, Histone Deacetylases, Histones, Humans, Models, Molecular, Nucleic Acid Conformation, Nucleosomes, Protein Processing, Post-Translational, Recombination, Genetic, Transcription, Genetic, Yeasts, Saccharomyces cerevisiae Proteins, Histone Acetyltransferases

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