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Cited by 874Nerve injury and regenerationAlzheimer's disease research and treatmentsNuclear Receptors and Signaling

The DOI matches its Crossref record; 550 of the 550 references it cites were found in a registry or an index.

Brain-derived neurotrophic factor in the control human brain, and in Alzheimer’s disease and Parkinson’s disease

Murer, M.G, Yan, Q, Raisman-Vozari, R·2001·Progress in Neurobiology
DOI 10.1016/s0301-0082(00)00014-9
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Abstract

Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to nerve growth factor, which is abundantly and widely expressed in the adult mammalian brain. BDNF has been found to promote survival of all major neuronal types affected in Alzheimer's disease and Parkinson's disease, like hippocampal and neocortical neurons, cholinergic septal and basal forebrain neurons, and nigral dopaminergic neurons. In this article, we summarize recent work on the molecular and cellular biology of BDNF, including current ideas about its intracellular trafficking, regulated synthesis and release, and actions at the synaptic level, which have considerably expanded our conception of BDNF actions in the central nervous system. But our primary aim is to review the literature regarding BDNF distribution in the human brain, and the modifications of BDNF expression which occur in the brain of individuals with Alzheimer's disease and Parkinson's disease. Our knowledge concerning BDNF actions on the neuronal populations affected in these pathological states is also reviewed, with an aim at understanding its pathogenic and pathophysiological relevance.

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Crossref · 10.1016/s0301-0082(00)00014-9

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Citations

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Show all 550 references

Research works printed but not linked: 5

  1. Beck, 1992, Pretreatment of dopaminergic neurons in culture with brain-derived neurotrophic factor attenuates toxicity of 1-methyl-4-phenyl-pyridinium, Neurodegeneration, 1, 27
  2. Engele, 1998, Changing responsiveness of developing midbrain dopaminergic neurons for extracelular growth factors, J. Neurosci. Res., 51, 508, 10.1002/(SICI)1097-4547(19980215)51:4<508::AID-JNR10>3.0.CO;2-# · DOI
  3. Griesbeck, 1999, Are there differences between the secretion characteristics of NGF and BDNF? Implications for the modulatory role of neurotrophins in activity-dependent neuronal plasticity, Microsc. Res. Tech., 45, 262, 10.1002/(SICI)1097-0029(19990515/01)45:4/5<262::AID-JEMT10>3.0.CO;2-K · DOI
  4. Hirsch, 1992, Expression of calbindin D28K-like immunoreactivity in catecholaminergic cell groups of the human midbrain: normal distribution and distribution in Parkinson’s disease, Neurodegeneration, 1, 83
  5. Kiprianova, 1999, Brain-derived neurotrophic factor prevents neuronal death and glial activation after global ischemia in the rat, J. Neurosci. Res., 56, 21, 10.1002/(SICI)1097-4547(19990401)56:1<21::AID-JNR3>3.0.CO;2-Q · DOI

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Metadata

Authors
Murer, M. G., Yan, Q., & Raisman-Vozari, R.
Affiliations
  • Universidad de Buenos Aires (AR)
  • Amgen (United States) (US)
Corresponding author
Murer, M.G
ORCID
Murer, M.G
Venue
Progress in Neurobiology
Publisher
Elsevier BV
Published
2001-01
Volume
63
Issue
1
Pages
71-124
ISSN
0301-0082 (ISSN-L)
DOI
10.1016/s0301-0082(00)00014-9
OpenAlex
W2063849763
Cited by
874
References
550
Citations by year
2026: 15 · 2025: 16 · 2024: 26 · 2023: 34 · 2022: 29 · 2021: 36 · 2020: 44 · 2019: 45 · 2018: 27 · 2017: 39 · 2016: 52 · 2015: 40 · 2014: 42 · 2013: 52 · 2012: 45
FWCI
2.22
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Progress in Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords
brain-derived neurotrophic factor, Alzheimer's disease, Parkinson's disease, neurotrophins, nerve growth factor, intracellular trafficking, neuronal survival, dopaminergic neurons, cholinergic neurons, hippocampal neurons, neurodegeneration
MeSH terms
Alzheimer Disease, Brain, Humans, Parkinson Disease, Reference Values, Tissue Distribution, Brain-Derived Neurotrophic Factor

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