Cited by 874Nerve injury and regenerationAlzheimer's disease research and treatmentsNuclear Receptors and Signaling

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Brain-derived neurotrophic factor in the control human brain, and in Alzheimer’s disease and Parkinson’s disease

Murer, M.G, Yan, Q, Raisman-Vozari, R·2001·Progress in Neurobiology

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Abstract

Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to nerve growth factor, which is abundantly and widely expressed in the adult mammalian brain. BDNF has been found to promote survival of all major neuronal types affected in Alzheimer's disease and Parkinson's disease, like hippocampal and neocortical neurons, cholinergic septal and basal forebrain neurons, and nigral dopaminergic neurons. In this article, we summarize recent work on the molecular and cellular biology of BDNF, including current ideas about its intracellular trafficking, regulated synthesis and release, and actions at the synaptic level, which have considerably expanded our conception of BDNF actions in the central nervous system. But our primary aim is to review the literature regarding BDNF distribution in the human brain, and the modifications of BDNF expression which occur in the brain of individuals with Alzheimer's disease and Parkinson's disease. Our knowledge concerning BDNF actions on the neuronal populations affected in these pathological states is also reviewed, with an aim at understanding its pathogenic and pathophysiological relevance.

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Authors: Murer, M. G., Yan, Q., & Raisman-Vozari, R.
Affiliations: Universidad de Buenos Aires (AR)
Amgen (United States) (US)
Corresponding author: Murer, M.G
ORCID: Murer, M.G
Venue: Progress in Neurobiology
Publisher: Elsevier BV
Published: 2001-01
Volume: 63
Issue: 1
Pages: 71-124
ISSN: 0301-0082 (ISSN-L)
DOI: 10.1016/s0301-0082(00)00014-9
OpenAlex: W2063849763
Cited by: 874
References: 550
Citations by year: 2026: 15 · 2025: 16 · 2024: 26 · 2023: 34 · 2022: 29 · 2021: 36 · 2020: 44 · 2019: 45 · 2018: 27 · 2017: 39 · 2016: 52 · 2015: 40 · 2014: 42 · 2013: 52 · 2012: 45
FWCI: 2.22
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords: brain-derived neurotrophic factor, Alzheimer's disease, Parkinson's disease, neurotrophins, nerve growth factor, intracellular trafficking, neuronal survival, dopaminergic neurons, cholinergic neurons, hippocampal neurons, neurodegeneration
MeSH terms: Alzheimer Disease, Brain, Humans, Parkinson Disease, Reference Values, Tissue Distribution, Brain-Derived Neurotrophic Factor

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Brain-derived neurotrophic factor in the control human brain, and in Alzheimer’s disease and Parkinson’s disease

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