Kinetic analysis of artificial peptide self-replication. Part II: The heterochiral case
Abstract
A kinetic model has been designed to describe and to analyze the stereoselective behavior of a recently discovered heterochiral template-directed peptide self-replicator by Ghadiri and co-workers [Nature 409 (2001) 797-801]. It turned out that previous assumptions stating that exclusively homochiral species participate in a stereoselective and autocatalytic pathway and that heterochiral species originate only from uncatalyzed background reactions could not be validated by our model. On the contrary, excellent fitting of experimental data indicated that the whole combinatorial variety of possible cross-catalytic processes involving L- and D- peptide species play an important role and need to be taken into account. The system shows no net creation of chiral matter but only a redistribution of the initially present chiral material. Both, the separation of an optically inactive meso-type template dimer and a slight chiroselective autocatalytic effect, contribute to a predicted amplification of enantiomeric excess that, in some cases, can simultaneously result in a substantial amount of optically active matter.
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The replicator entails a stereoselective autocatalytic cycle, for which all bimolecular steps are faster for matched versus unmatched pairs of substrate enantiomers.
“The replicator entails a stereoselective autocatalytic cycle, for which all bimolecular steps are faster for matched versus unmatched pairs of substrate enantiomers”
From Possible chemical and physical scenarios towards biological homochirality (2022) · cites this paper as [542]
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- Authors
- Rivera Islas, J., Pimienta, V., Micheau, J.-C., & Buhse, T.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Universidad Autónoma del Estado de Morelos (MX)
- Corresponding author
- Buhse, Thomas
- Venue
- Biophysical Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-03
- Volume
- 103
- Issue
- 3
- Pages
- 201-211
- ISSN
- 0301-4622 (ISSN-L)
- OpenAlex
- W4250931849
- Cited by
- 15
- References
- 26
- Citations by year
- 2022: 1 · 2021: 1 · 2019: 1 · 2017: 1 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 0.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biophysical Chemistry (publishedVersion)
- Funders
- Consejo Nacional de Ciencia y Tecnología
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- kinetic modeling, stereoselectivity, autocatalysis, cross-catalysis, enantiomeric excess amplification, chiral amplification
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