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Cited by 109Adrenal Hormones and DisordersHormonal Regulation and HypertensionSexual Differentiation and Disorders

The DOI matches its Crossref record; 47 of the 51 references it cites were found in a registry or an index.

Temporal and spatial distribution of Corticosteroidogenic Enzymes Immunoreactivity in developing human adrenal

Narasaka, Toshiaki, Suzuki, Takashi, Moriya, Takuya, Sasano, Hironobu·2001·Molecular and Cellular Endocrinology
DOI 10.1016/s0303-7207(00)00445-7
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Abstract

Steroid hormones secreted by fetal adrenocortical cells are considered to be a requirement for a fetus to maintain intrauterine life, but, to date, the regulation of steroid hormone secretion has not been studied in detail in the human fetal adrenal gland. In this study, we examined the immunolocalization of steroidogenic enzymes and their local regulation, including adrenal 4-binding protein (Ad4BP or NR5A1), steroidogenic acute regulatory protein (StAR), P450 cholesterol side-chain cleavage (P450scc or CYP11A1), P450 17alpha-hydroxylase/17,20-lyase (P450c17 or CYP17), 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD), P450 21 hydroxylase (P450c21 or CYP21), dehydroepiandrosterone sulfotransferase (DHEA-ST), P450 oxidoreductase and cytochrome b5, in the human fetal adrenal gland (n=31) obtained from fetuses ranging in ages from 14 to 40 weeks of gestation. Ad4BP immunoreactivity was detected in all adrenocortical zones throughout gestation, suggesting that this nuclear protein is likely to be essential in the development of the human adrenal. Immunoreactivity for StAR, P450scc, P450c21, P450 oxidoreductase and cytochrome b5 was detected only in fetal and transitional zone between 14 and 22 weeks of gestation, but was detected in all three zones after 23 gestational weeks. 3beta-HSD immunoreactivity was not detected in any of the three cortical zones prior to 22 weeks of gestation, but became discernible in the transitional zone and definitive zone after 23 weeks. Immunoreactivity for P450c17 and DHEA-ST was detected in the transitional and fetal zones throughout gestation, but not in the definitive zone. These results suggest that the human adrenal cortex may produce dehydroepiandrosterone (DHEA) in the transitional and fetal zones throughout gestation, and cortisol in the transitional zone after the 23rd week of gestation.

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Crossref · 10.1016/s0303-7207(00)00445-7

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Research works printed but not linked: 3

  1. Mapes, 1999, J. Clin. Endocrinol. Metab., 84, 3382
  2. McNutt, 1970, Observations on the ultrastructure of cytodifferntiation in the human fetal adrenal cortex, Lab. Invest., 11, 513
  3. Mesiano, 1993, J. Clin. Endocrinol. Metab., 77, 1184

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Metadata

Authors
Narasaka, T., Suzuki, T., Moriya, T., & Sasano, H.
Affiliations
Tohoku University (JP)
Corresponding author
Narasaka, Toshiaki
ORCID
Venue
Molecular and Cellular Endocrinology
Publisher
Elsevier BV
Published
2001-03
Volume
174
Issue
1-2
Pages
111-120
ISSN
0303-7207 (ISSN-L)
DOI
10.1016/s0303-7207(00)00445-7
OpenAlex
W1980898029
Cited by
109
References
51
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 8 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 7 · 2014: 2 · 2012: 2
FWCI
5.99
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Molecular and Cellular Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Education, Culture, Sports, Science and Technology (B-11470047)
  • Naito Foundation
  • Ministry of Health, Labour and Welfare (A-11137301)
  • Suzuken Memorial Foundation
  • Japan Society for the Promotion of Science
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords
fetal adrenal gland, adrenal cortex development, steroidogenic enzymes, immunoreactivity, gestational age, dehydroepiandrosterone, cortisol, steroidogenic acute regulatory protein, 3β-hydroxysteroid dehydrogenase, 17α-hydroxylase/17,20-lyase, 21-hydroxylase, cytochrome P450 oxidoreductase, cytochrome b5
MeSH terms
Steroidogenic Acute Regulatory Protein, Adrenal Cortex Hormones, Adrenal Glands, DNA-Binding Proteins, Enzymes, Female, Fetus, Humans, Immunohistochemistry, Male, Phosphoproteins, Pregnancy, Pregnancy Trimester, Second, Transcription Factors, Receptors, Cytoplasmic and Nuclear, Homeodomain Proteins, Fushi Tarazu Transcription Factors, Steroidogenic Factor 1

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