Zebrafish insulin-like growth factor-I receptor: molecular cloning and developmental expression

Ayaso, E; Nolan, C.M; Byrnes, L

doi:10.1016/s0303-7207(02)00083-7

Cited by 41Growth Hormone and Insulin-like Growth FactorsDevelopmental Biology and Gene RegulationZebrafish Biomedical Research Applications

Zebrafish insulin-like growth factor-I receptor: molecular cloning and developmental expression

Ayaso, E, Nolan, C.M, Byrnes, L·2002·Molecular and Cellular Endocrinology

DOI 10.1016/s0303-7207(02)00083-7

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Abstract

The biological actions of the insulin-like growth factors (IGFs) are mediated primarily by the IGF-I receptor (IGF-IR), and the IGF family has been highly conserved throughout vertebrate evolution. In this study we report the isolation of a 3 kb cDNA clone for the zebrafish IGF-IR that includes the complete 3' untranslated region and polyA tail and mapping of the receptor gene to zebrafish linkage group 7. The open reading frame deduced from the cDNA sequence encompasses the juxtamembrane and protein tyrosine kinase portions of the receptor, and is 70 and 67% identical to the corresponding regions of the IGF-IRs of the turbot and Xenopus, respectively. By RT-PCR, zebrafish IGF-IR expression was detected from early blastula to early larval stages of development. Using whole mount in situ hybridization, IGF-IR expression was detected after gastrulation. Expression was evident in most tissues but was particularly evident in the tail, in eye and ear primordia and in the brain.

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Human IGF-1 acts via zebrafish receptors because the mature peptide shares about 81% identity with zebrafish IGF-1, including key receptor-binding residues, and human and zebrafish IGF-IR share over 80% similarity with conserved ligand-binding residues.
“We suspected human IGF-1 would act via zebrafish receptors because the mature peptide shares ~81% identity with that of zebrafish (Zou et al., 2009), including key residues important for receptor binding (Gauguin et al., 2008). Furthermore, human and zebrafish IGF-IR share over 80% similarity and key residues involved in ligand binding are preserved (Ayaso et al., 2002; Renteria et al., 2008).”
From Retinal injury, growth factors, and cytokines converge on β-catenin and pStat3 signaling to stimulate retina regeneration (2014) · cites this paper as Ayaso et al., 2002

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“Furthermore, human and zebrafish IGF-IR share over 80% similarity and key residues involved in ligand binding are preserved (Ayaso et al., 2002; Renteria et al., 2008).”
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Authors: Ayaso, E., Nolan, C. M., & Byrnes, L.
Affiliations: Ollscoil na Gaillimhe – University of Galway (IE)
University College Dublin (IE)
Corresponding author: Byrnes, L
ORCID: Nolan, C.M
Venue: Molecular and Cellular Endocrinology
Publisher: Elsevier BV
Published: 2002-06
Volume: 191
Issue: 2
Pages: 137-148
ISSN: 0303-7207 (ISSN-L)
DOI: 10.1016/s0303-7207(02)00083-7
OpenAlex: W2110449691
Cited by: 41
References: 45
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 1 · 2014: 2 · 2013: 1 · 2012: 2
FWCI: 1.14
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Molecular and Cellular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Health Research Board
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
Keywords: IGF-1 receptor, zebrafish, cDNA cloning, gene mapping, tyrosine kinase, developmental gene expression, gastrulation, brain expression
MeSH terms: Animals, Base Sequence, Cloning, Molecular, Embryonic and Fetal Development, Genetic Linkage, Molecular Sequence Data, Protein-Tyrosine Kinases, Sequence Homology, Nucleic Acid, Zebrafish, Open Reading Frames, Receptor, IGF Type 1, DNA, Complementary, Gene Expression Regulation, Developmental, 3' Untranslated Regions

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Zebrafish insulin-like growth factor-I receptor: molecular cloning and developmental expression

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