Zebrafish Comparative Genomics and the Origins of Vertebrate Chromosomes
Open accessAbstract
To help understand mechanisms of vertebrate genome evolution, we have compared zebrafish and tetrapod gene maps. It has been suggested that translocations are fixed more frequently than inversions in mammals. Gene maps showed that blocks of conserved syntenies between zebrafish and humans were large, but gene orders were frequently inverted and transposed. This shows that intrachromosomal rearrangements have been fixed more frequently than translocations. Duplicated chromosome segments suggest that a genome duplication occurred in ray-fin phylogeny, and comparative studies suggest that this event happened deep in the ancestry of teleost fish. Consideration of duplicate chromosome segments shows that at least 20% of duplicated gene pairs may be retained from this event. Despite genome duplication, zebrafish and humans have about the same number of chromosomes, and zebrafish chromosomes are mosaically orthologous to several human chromosomes. Is this because of an excess of chromosome fissions in the human lineage or an excess of chromosome fusions in the zebrafish lineage? Comparative analysis suggests that an excess of chromosome fissions in the tetrapod lineage may account for chromosome numbers and provides histories for several human chromosomes.
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Analysis does not support extrapolating accelerated molecular evolution documented in flies and echinoderms to all invertebrates.
“While accelerated rates of molecular evolution have been documented in flies and echinoderms (43) relative to vertebrates, our analysis does not support the extrapolation of these higher rates to all invertebrates.”
From Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization (2007) · cites this paper as [43]
Panther ontology annotations of the inferred ancestral gene set show significant over- and under-representations in each of the three categories of novelty (novel sequence, novel domain, and novel combination of domains).
“Panther ontology annotations of the inferred ancestral gene set have been tested for enrichment in each of the three categories of novelty (novel sequence, novel domain, and novel combination of domains), as described in section S8, and significant over-and under-representations have been tabulated here”
From Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization (2007) · cites this paper as [43]
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- Authors
- Postlethwait, J. H., Woods, I. G., Ngo-Hazelett, P., Yan, Y.-L., Kelly, P. D., Chu, F., Huang, H., Hill-Force, A., & Talbot, W. S.
- Affiliations
- University of Oregon (US)
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-12-01
- Volume
- 10
- Issue
- 12
- Pages
- 1890-1902
- ISSN
- 1088-9051 (ISSN-L)
- 1549-5469
- OpenAlex
- W2066187005
- Cited by
- 688
- References
- 79
- Citations by year
- 2026: 9 · 2025: 17 · 2024: 16 · 2023: 11 · 2022: 23 · 2021: 33 · 2020: 21 · 2019: 15 · 2018: 25 · 2017: 25 · 2016: 11 · 2015: 23 · 2014: 22 · 2013: 26 · 2012: 26
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genome Research (publishedVersion)
- PubMed (publishedVersion)
- Digital Collections - Ithaca College Library (Ithaca College) (submittedVersion, public-domain)
- Funders
- National Science Foundation (9728587, 9602828)
- W. M. Keck Foundation
- M.J. Murdock Charitable Trust
- University of Oregon
- National Institutes of Health (5r01dk055378-04)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK55378)
- National Center for Research Resources (R01RR010715, R01RR012349, R01RR12349, R01 RR10715)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genome Rearrangement Algorithms
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Keywords
- zebrafish, comparative genomics, syntenic blocks, chromosomal inversions, translocation, intrachromosomal rearrangements, whole-genome duplication, teleosts, Actinopterygii, duplicate genes, chromosome fission, chromosome fusion, gene order
- MeSH terms
- Animals, Chromosome Mapping, Chromosomes, Chromosomes, Human, Pair 10, Chromosomes, Human, Pair 11, Chromosomes, Human, Pair 15, Chromosomes, Human, Pair 17, Chromosomes, Human, Pair 19, Chromosomes, Human, Pair 9, Genetic Markers, Humans, Genetic Linkage, Models, Genetic, Zebrafish, Genome, Evolution, Molecular, Gene Duplication, Mice
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