cDNA cloning and expression of human activin βE subunit
Abstract
We cloned human activin betaE subunit cDNA from a liver cDNA library using the polymerase chain reaction (PCR) technique. The deduced amino acid sequence was 97 and 96% homologous to the mouse and rat activin betaE subunits. Human activin betaE subunit tagged with Myc and polyhistidine residues at the COOH terminus was expressed in mammalian cells and secreted into the medium as a disulphide-linked homodimer protein. We also found that the human activin betaE protein could bind to follistatin, an activin-binding protein. Northern blot analysis showed that this gene was expressed as a major transcript of 2.7 kb predominantly in human liver. These findings suggest that activin E (dimeric protein) may play a role in humans.
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Activin-E is expressed and secreted primarily by the liver, unlike other activins that are expressed throughout the body.
“Activin-E (also called inhibin subunit beta E) was recently identified in humans and rodents and, unlike other activins that are expressed throughout the body, activin-E is expressed and secreted primarily by the liver [27,28].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [27]
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- Authors
- Hashimoto, O., Tsuchida, K., Ushiro, Y., Hosoi, Y., Hoshi, N., Sugino, H., & Hasegawa, Y.
- Affiliations
- Kitasato University (JP)
- Tokushima University (JP)
- Corresponding author
- Hashimoto, Osamu
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 194
- Issue
- 1-2
- Pages
- 117-122
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W1973525889
- Cited by
- 54
- References
- 25
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 4 · 2022: 1 · 2020: 1 · 2019: 2 · 2018: 3 · 2016: 2 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- cDNA cloning, liver, protein secretion, gene expression, amino acid sequence homology, TGF-beta superfamily
- MeSH terms
- Base Sequence, Cloning, Molecular, Humans, Liver, Molecular Sequence Data, RNA, Messenger, Gene Library, Sequence Alignment, Sequence Analysis, DNA, DNA, Complementary, Inhibin-beta Subunits, Follistatin
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