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Cited by 27Hormonal Regulation and HypertensionAdrenal and Paraganglionic TumorsAdrenal Hormones and Disorders

Expression of 11β-hydroxysteroid dehydrogenase type 2 (11βHSD-2) in the developing human adrenal gland and human adrenal cortical carcinoma and adenoma

Coulter, Catherine L, Smith, Robin E, Stowasser, Michael, Sasano, Hironobu, Krozowski, Zygmunt S, Gordon, Richard D·1999·Molecular and Cellular Endocrinology
DOI 10.1016/s0303-7207(99)00077-5
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Abstract

The aim of this study was to investigate the ontogeny of localization of 11betaHSD-2 protein in the human adrenal gland. In addition, we have investigated the effects of abnormal adrenal function on 11betaHSD-2 by determining the pattern of localization of 11betaHSD-2 protein, and the amount and level of expression of 11betaHSD-2 mRNA and protein in human adrenal cortical carcinoma and adenoma. In the human foetal adrenal gland 11betaHSD-2 immunoreactivity (11betaHSD-2-ir) was detected in the foetal zone, whereas in normal adult adrenal glands 11betaHSD-2-ir was not detected by immunocytochemistry. In adrenal cortical carcinoma and adenoma, 11betaHSD-2-ir was detectable in specific regions, which have been identified as steroid synthesizing cells using 3betaHSD-ir as a marker. In adrenal cortical carcinoma and adenoma, 11betaHSD-2 mRNA and 11betaHSD-2 protein were detected by nuclease protection analysis and by western blot analysis, respectively. In summary, 11betaHSD-2-ir was detected in the foetal zone of the mid-gestation human foetal adrenal, whereas, 11betaHSD-2-ir was not detectable in the postnatal or normal adult adrenal gland. 11BetaHSD-2 protein and mRNA was induced in adult human adrenal cortical carcinoma and adenoma. The induction of expression of 11betaHSD-2 in the adrenal cortex suggests a possible role in regulating abnormal adrenal steroidogenic function in these patients.

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  • Significant levels of 11KA4 measured in serum of healthy premenopausal women support the involvement of peripheral tissue such as the kidney, especially considering that the adrenal expresses only low levels of HSD11B2.

    “The significant levels of 11KA4 measured in the serum of healthy premenopausal woman (O'Reilly et al., 2016) supports the involvement of peripheral tissue such as the kidney, especially considering that the adrenal expresses only low levels of HSD11B2 (Coulter et al., 1999).”

    From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Coulter et al., 1999

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Authors
Coulter, C. L., Smith, R. E., Stowasser, M., Sasano, H., Krozowski, Z. S., & Gordon, R. D.
Affiliations
Tohoku University (JP)
Corresponding author
Coulter, Catherine L
ORCID
Venue
Molecular and Cellular Endocrinology
Publisher
Elsevier BV
Published
1999-08
Volume
154
Issue
1-2
Pages
71-77
ISSN
0303-7207 (ISSN-L)
DOI
10.1016/s0303-7207(99)00077-5
OpenAlex
W2026588638
Cited by
27
References
25
Citations by year
2026: 1 · 2025: 1 · 2023: 1 · 2021: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2013: 2
FWCI
0.92
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Molecular and Cellular Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
11β-hydroxysteroid dehydrogenase type 2, adrenal development, adrenocortical carcinoma, adrenal adenoma, fetal adrenal gland, adrenal steroidogenesis, gene expression regulation, 3β-hydroxysteroid dehydrogenase
MeSH terms
Adrenal Glands, Adult, Fetus, Humans, Hydroxysteroid Dehydrogenases, Immunohistochemistry, Infant, Newborn, Kidney, Methods, Ribonucleases, RNA, Messenger, Blotting, Western, Adrenocortical Adenoma, Adrenocortical Carcinoma, 11-beta-Hydroxysteroid Dehydrogenases

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