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Cited by 42Adrenal Hormones and DisordersEstrogen and related hormone effectsBirth, Development, and Health

A role for epidermal growth factor in the morphological and functional maturation of the adrenal gland in the fetal rhesus monkey in vivo.

Coulter, C L, Read, L C, Carr, B R, Tarantal, A F, Barry, S, Styne, D M·1996·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.81.3.8772608
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Abstract

We determined the effects of epidermal growth factor (EGF) and beta-methasone on the growth and development of the adrenal gland of the fetal rhesus monkey in vivo between 121-128 days of gestation. The adrenal to body weight ratio was significantly greater (P < 0.05) in EGF-treated fetuses (0.988 +/- 0.046 x 10(-3) g/g) and significantly reduced (P < 0.05) in beta-methasone-treated fetuses (0.401 +/- 0.056 x 10(-3) g/g) compared with that in control fetuses (0.689 +/- 0.050 x 10(-3) g/g). The increase in adrenal weight with EGF administration was due to hypertrophy of definitive zone cells of the adrenal cortex, whereas the reduction in adrenal weight after beta-methasone treatment was due to a decrease in the size of definitive and fetal zone cells of the adrenal cortex. By Western analysis, EGF treatment induced a significant (P < 0.05) 2.8-fold increase in the amount of protein for 3 beta-hydroxysteroid dehydrogenase/isomerase (3 beta HSD) in the fetal adrenal. EGF also stimulated the induction of immunocytochemical staining for 3 beta HSD in transitional zone cells of the adrenal cortex. In contrast, beta-methasone resulted in 2.6-, 4.5-, and 6.6-fold significant decreases (P < 0.05) in the amount of protein for cytochrome P450 cholesterol side-chain cleavage, cytochrome P450 17 alpha-hydroxylase/17,20-lyase, and 3 beta HSD in the fetal adrenal. After beta-methasone treatment. 3 beta HSD staining was detected in some of the definitive zone cells, with no 3 beta HSD staining in the transitional zone. In conclusion, growth and functional differentiation of fetal primate adrenal gland can be accelerated prematurely by EGF and inhibited by glucocorticoid negative feedback.

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  • ACTH promotes adrenal growth primarily by stimulating cAMP production, which promotes synthesis of IGF-II, basic fibroblast growth factor, and epidermal growth factor; together these growth factors stimulate adrenal cellular hypertrophy and hyperplasia, determining the amount of steroidogenic tissue.

    “This growth occurs primarily by ACTH stimulating the production of cAMP, which in turn promotes the synthesis of IGF-II (54, 55), basic fibroblast growth factor (56), and epidermal growth factor (57). Together, these growth factors stimulate adrenal cellular hypertrophy and hyperplasia, determining the amount of steroidogenic tissue.”

    From The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders (2011) · cites this paper as [57]

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Authors
Coulter, C. L., Read, L. C., Carr, B. R., Tarantal, A. F., Barry, S., & Styne, D. M.
Affiliations
University of California, San Francisco (US)
ORCID
Styne, D M
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1996-03
Volume
81
Issue
3
Pages
1254-1260
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.81.3.8772608
OpenAlex
W2076911155
Cited by
42
References
0
Citations by year
2020: 1 · 2016: 1 · 2015: 2 · 2014: 2
FWCI
2.15
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Kementerian Pendidikan Nasional
  • National Institutes of Health (5r01hd024959-05, 5r01hd017814-05)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD17814, HD24959, HD-08478)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
epidermal growth factor, fetal adrenal gland, adrenal development, betamethasone, glucocorticoid negative feedback, 3β-hydroxysteroid dehydrogenase, adrenal cortex, zona fasciculata, zona glomerulosa, steroidogenic enzymes, adrenal hypertrophy, gestation
MeSH terms
Adrenal Glands, Adrenocorticotropic Hormone, Animals, Betamethasone, Epidermal Growth Factor, Embryonic and Fetal Development, Fetus, Immunohistochemistry, Macaca mulatta, Pituitary Gland, Tissue Distribution, 3-Hydroxysteroid Dehydrogenases, Blotting, Western

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