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Cited by 3Carcinogens and Genotoxicity AssessmentCancer and biochemical researchNephrotoxicity and Medicinal Plants

Concurrent administration of fish meal and sodium nitrite does not promote renal carcinogenesis in rats after initiation with N-ethyl-N-hydroxyethylnitrosamine

Furukawa, Fumio, Nishikawa, Akiyoshi, Miyauchi, Makoto, Nakamura, Hideaki, Son, Hwa-Young, Yamagishi, Megumi, Hirose, Masao·2000·Cancer Letters
DOI 10.1016/s0304-3835(00)00357-8
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Abstract

The modifying effects of concurrent administration of fish meal and sodium nitrite on the development of renal tumors after initiation with N-ethyl-N-hydroxyethylnitrosamine (EHEN) were investigated. A total of 120 male 6-week-old Wistar rats were divided into six groups. Groups 1-3 (30 animals each) were given 1000 ppm EHEN in their drinking water for 3 weeks as an initiation treatment for renal cancer induction and thereafter fed respective diets containing 64, 32, and 8% (original concentration in the basal diet) fish meal, and simultaneously given 0.12% sodium nitrite in the drinking water for 33 weeks. Groups 4-6 (ten animals each) were similarly treated without the prior application of EHEN. At the end of the 37th experimental week, all surviving animals were autopsied and examined histopathologically for the existence of renal proliferative lesions. The incidences of dysplastic lesions, adenomas or adenocarcinomas of the kidney were not significantly different among groups 1-3. No renal proliferative lesions were found in groups 4-6. Chronic nephropathy was slightly but significantly enhanced in the 64 and 32% fish meal-treated groups as compared with group 3. Our results suggest that concurrent administration of fish meal and sodium nitrite does not affect the post-initiation phase of EHEN-induced renal carcinogenesis in the rat.

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  • Sodium nitrite does not significantly contribute to cellular transformation.

    “However, studies also indicated that sodium nitrite does not significantly contribute to cellular transformation [272, 273].”

    From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [273]

  • Nitrite could potentially bind and activate ER-α+ breast cancer cells thereby influencing their growth.

    “Studies have addressed this concern with Veselik et al indicating that nitrite could potentially bind and activate ER-α+ breast cancer cells thereby influencing their growth [273–275].”

    From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [273]

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Authors
Furukawa, F., Nishikawa, A., Miyauchi, M., Nakamura, H., Son, H.-Y., Yamagishi, M., & Hirose, M.
Affiliations
National Institute of Health Sciences (JP)
Corresponding author
Furukawa, Fumio
ORCID
Venue
Cancer Letters
Publisher
Elsevier BV
Published
2000-06
Volume
154
Issue
1
Pages
45-51
ISSN
0304-3835 (ISSN-L)
DOI
10.1016/s0304-3835(00)00357-8
OpenAlex
W2057455114
Cited by
3
References
23
Citations by year
2015: 1
FWCI
0.14
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Cancer Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Nephrotoxicity and Medicinal Plants
Keywords
renal carcinogenesis, fish meal, sodium nitrite, tumor promotion, chronic nephropathy, renal adenoma, renal cell carcinoma, renal dysplasia, dietary protein
MeSH terms
Adenocarcinoma, Adenoma, Adrenal Glands, Animals, Body Weight, Cocarcinogenesis, Diet, Diethylnitrosamine, Fish Products, Kidney, Kidney Neoplasms, Liver, Male, Organ Size, Sodium Nitrite, Time Factors, Rats, Wistar, Proliferating Cell Nuclear Antigen, Rats

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