The microcirculation in two transplantable melanomas of the hamster. I. In vivo observations in transparent chambers
Abstract
Twenty-eight transparent chambers were inserted into the cheek pouches of hamsters and daily serial observations made of the changing vasculature of transplants of 2 varieties (A-Mel-4B32, ZGYP1) of amelanotic melanomas. The tumor A-Mel-4B32 grew at a rate which covered 50% of the viewing area in 3--4 days, while the tumor ZGYP1 covered less than 10% of the viewing area at this time and did not cover 50% of the viewing area until 9.5 days after transplantation. The difference in growth rate was not reflected in any differences in the morphology of the vascular network and distribution of the venous arcades.
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Tumor-associated blood vessels are structurally aberrant, displaying irregular diameters, lack of hierarchical architecture, and increased permeability and fragility.
“Unlike normal vasculature, tumor-associated blood vessels are structurally aberrant [54]. They display irregular diameters, lack the hierarchical architecture typical of the arterial-arteriolar-capillary network, and exhibit increased permeability and fragility [55,56].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [55]
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Discriminating Breast Cancer Patients by Spectral Analysis of Arterial Pulse Waveforms
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- Authors
- Warren, B. A., Shubik, P., Wilson, R., Garcia, H., & Feldman, R.
- Affiliations
- Western University (CA)
- University of Nebraska Medical Center (US)
- ORCID
- Warren, B.A.
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 1978-01
- Volume
- 4
- Issue
- 2
- Pages
- 109-116
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W2074022248
- Cited by
- 14
- References
- 5
- Citations by year
- 2026: 2 · 2025: 1 · 2022: 1 · 2018: 1 · 2017: 2 · 2016: 1
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pfizer
- U.S. Public Health Service
- National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
- Keywords
- tumor microcirculation, amelanotic melanoma, hamster cheek pouch, transparent chamber, tumor vasculature, tumor growth rate
- MeSH terms
- Animals, Cheek, Cricetinae, Melanoma, Microcirculation, Neoplasm Transplantation, Neoplasms, Experimental
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