Allelic association between the D10S1423 marker and Alzheimer's disease in a German population
Abstract
Recently a full genome survey detected an allelic association between Alzheimer's disease (AD) and the D10S1423 marker on chromosome 10p12-14 (40 cM from the telomere). In this study we examined the D10S1423 marker in an ethnically homogeneous German population of 80 AD patients and two groups of controls, 168 healthy subjects and 149 depressed patients. The 234-bp allele of the D10S1423 marker showed a significant association with AD (P = 0.033). In conclusion, our results support that the D10S1423 marker is associated with an increased AD risk and provides further evidence for an AD susceptibility locus on chromosome 10.
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An allele on chromosome 10p12-14 is associated with increased AD risk.
“For example, an allele on chromosome 10p12–14 (40 centimorgan from the telomere) has been associated with increased AD risk [504].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [504]
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Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease
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“Nevertheless, one of the markers associated with Alzheimer’s disease in the first large-scale LD mapping of Alzheimer’s disease (34), D10S1423, was repeatedly shown to be associated with Alzheimer’s disease in ethnically different independent populations (36).”
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- Authors
- Majores, M., Bagli, M., Papassotiropoulos, A., Schwab, S. G., Jessen, F., Rao, M. L., Maier, W., & Heun, R.
- Affiliations
- University of Bonn (DE)
- Corresponding author
- Bagli, Metin
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2000-08
- Volume
- 289
- Issue
- 3
- Pages
- 224-226
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2111916207
- Cited by
- 23
- References
- 10
- Citations by year
- 2020: 1 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- Alzheimer's disease, allelic association, genetic susceptibility, chromosome 10, genetic polymorphism, German population, depression
- MeSH terms
- Aged, Aged, 80 and over, Alleles, Alzheimer Disease, Chromosomes, Human, Pair 10, DNA Mutational Analysis, Germany, Humans, Middle Aged, Risk Factors, Microsatellite Repeats
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