Molecular Genetics of Late‐Onset Alzheimer's Disease

Kamboh, M. Ilyas

doi:10.1046/j.1529-8817.2004.00110.x

Cited by 170Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchGenetic Associations and Epidemiology

Molecular Genetics of Late‐Onset Alzheimer's Disease

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Kamboh, M. Ilyas·2004·Annals of Human Genetics

DOI 10.1046/j.1529-8817.2004.00110.x

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Abstract

Summary: Late‐onset Alzheimer's disease (AD) is a complex and multifactorial disease with the possible involvement of several genes. Apolipoprotein E (APOE), especially the APOE*4 allele, has been established as a strong susceptibility marker that accounts for nearly 30% of the risk in late‐onset AD. However, as the APOE*4 allele is neither necessary nor sufficient for the development of AD, it emphasizes the involvement of other genetic and/or environmental factors which, alone or in conjunction with APOE*4, can modify the risk of AD. Recently, genome‐wide linkage or linkage disequilibrium studies on late‐onset AD have provided informative data for the existence of multiple putative genes for AD on several chromosomes, with the strongest evidence on chromosomes 12, 10, 9 and 6. This paper attempts to review the current progress on the identification of additional genetic loci for late‐onset AD.

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The APOE polymorphism is the most studied, successfully replicated, and well-established risk factor for Alzheimer's disease, with APOE*2 protective and APOE*4 risk compared to APOE*3.
“The APOE polymorphism is the most studied, successfully replicated, and well-established risk factor for AD where APOE*2 is the protective allele and APOE*4 is the risk allele as compared to APOE*3 [7–10].”
From Genome-wide analysis identifies novel loci influencing plasma apolipoprotein E concentration and Alzheimer’s disease risk (2023) · cites this paper as [9]

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Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
Sørlie, T., Perou, C., Tibshirani, R., Aas, T., Geisler, S., Johnsen, H., Hastie, T., Eisen, M., van de Rijn, M., Jeffrey, S., et al. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.191367098 · Cited by 11,695 · see citing works
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) · Nature · doi:10.1038/349704a0 · Cited by 4,659 · see citing works
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) · Nature · doi:10.1038/375754a0 · Cited by 4,051 · see citing works
Candidate gene for the chromosome 1 familial Alzheimer’s disease locus
Levy-Lahad, E., Wasco, W., Poorkaj, P., Romano, D. M., Oshima, J., Pettingell, W. H., Yu, C.-E., Jondro, P. D., Schmidt, S. D., Wang, K., et al. (1995) · Science · doi:10.1126/science.7638622 · Cited by 2,577 · see citing works
Exploring the new world of the genome with DNA microarrays
Brown, P. O., & Botstein, D. (1999) · Nature Genetics · doi:10.1038/4462 · Cited by 2,430 · see citing works
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
Rogaev, E. I., Sherrington, R., Rogaeva, E. A., Levesque, G., Ikeda, M., Liang, Y., Chi, H., Lin, C., Holman, K., Tsuda, T., et al. (1995) · Nature · doi:10.1038/376775a0 · Cited by 2,052 · see citing works
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., & Van Leuven, F. (1998) · Nature · doi:10.1038/34910 · Cited by 1,818 · see citing works
Accumulation of Dietary Cholesterol in Sitosterolemia Caused by Mutations in Adjacent ABC Transporters
Berge, K. E., Tian, H., Graf, G. A., Yu, L., Grishin, N. V., Schultz, J. R., Kwiterovich, P. O., Shan, B., Barnes, R., & Hobbs, H. H. (2000) · Science · doi:10.1126/science.290.5497.1771 · Cited by 1,645 · see citing works
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
Lewis, J., Dickson, D. W., Lin, W.-L., Chisholm, L., Corral, A., Jones, G., Yen, S.-H., Sahara, N., Skipper, L., Yager, D., et al. (2001) · Science · doi:10.1126/science.1058189 · Cited by 1,611 · see citing works
Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils
Götz, J., Chen, F., van Dorpe, J., & Nitsch, R. M. (2001) · Science · doi:10.1126/science.1062097 · Cited by 1,526 · see citing works
Uber eine eigenartige Erkrankung der Hirnrinde
Alzheimer, A. (1907) · Medical Entomology and Zoology · Cited by 1,503 · see citing works
Alzheimer's Disease and Parkinson's Disease
Nussbaum, R. L., & Ellis, C. E. (2003) · New England Journal of Medicine · doi:10.1056/nejm2003ra020003 · Cited by 1,351 · see citing works
Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
West, M. J., Coleman, P. D., Flood, D. G., & Troncoso, J. C. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92338-8 · Cited by 1,267 · cited 1× · see citing works
“OLR1 also binds to apoptotic cells (Oka et al. 1998; Kataoka et al. 2001) and since neuronal apoptosis is common in AD patients (West et al. 1994; Friedlander 2003), it can affect the risk of AD by its involvement in the mechanism of cell death.”
Background
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease
Holtzman, D. M., Bales, K. R., Tenkova, T., Fagan, A. M., Parsadanian, M., Sartorius, L. J., Mackey, B., Olney, J., McKeel, D., Wozniak, D., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050004797 · Cited by 937 · see citing works
Apoptosis and Caspases in Neurodegenerative Diseases
Friedlander, R. M. (2003) · New England Journal of Medicine · doi:10.1056/nejmra022366 · Cited by 873 · see citing works
The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway
Lawn, R. M., Wade, D. P., Garvin, M. R., Wang, X., Schwartz, K., Porter, J. G., Seilhamer, J. J., Vaughan, A. M., & Oram, J. F. (1999) · Journal of Clinical Investigation · doi:10.1172/jci8119 · Cited by 724 · see citing works
Molecular characterisation of soft tissue tumours: a gene expression study
Nielsen, T. O., West, R. B., Linn, S. C., Alter, O., Knowling, M. A., OʼConnell, J. X., Zhu, S., Fero, M., Sherlock, G. J., Pollack, J. R., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08270-3 · Cited by 574 · see citing works
Frameshift Mutants of β Amyloid Precursor Protein and Ubiquitin-B in Alzheimer's and Down Patients
van Leeuwen, F. W., de Kleijn, D. P. V., van den Hurk, H., Neubauer, A., Sonnemans, M. A. F., Sluijs, J. A., Köycü, S., Ramdjielal, R. D. J., Salehi, A., Martens, G. J. M., et al. (1998) · Science · doi:10.1126/science.279.5348.242 · Cited by 561 · see citing works
Evidence for Genetic Linkage of Alzheimer's Disease to Chromosome 10q
Bertram, L., Blacker, D., Mullin, K., Keeney, D. B., Jones, J., Basu, S., Yhu, S., McInnis, M. G., Go, R. C. P., Vekrellis, K., et al. (2000) · Science · doi:10.1126/science.290.5500.2302 · Cited by 519 · see citing works
Neurons Regulate Extracellular Levels of Amyloid β-Protein via Proteolysis by Insulin-Degrading Enzyme
Vekrellis, K., Ye, Z., Qiu, W. Q., Walsh, D. M., Hartley, D. M., Chesneau, V., Rosner, M. R., & Selkoe, D. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-05-01657.2000 · Cited by 495 · see citing works
LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation
Kounnas, M. Z., Moir, R. D., Rebeck, G. W., Bush, A. I., Argraves, W. S., Tanzi, R. E., Hyman, B. T., & Strickland, D. K. (1995) · Cell · doi:10.1016/0092-8674(95)90320-8 · Cited by 489 · see citing works
Risk Estimates of Dementia by Apolipoprotein E Genotypes From a Population-Based Incidence Study: The Rotterdam Study
Slooter, A. J. C., Cruts, M., Kalmijn, S., Hofman, A., Breteler, M. M. B., Van Broeckhoven, C., & van Duijn, C. M. (1998) · Archives of Neurology · doi:10.1001/archneur.55.7.964 · Cited by 399 · cited 2× · see citing works
“The risk attributable to the APOE∗4 allele is 20–29% (Seshadri et al. 1995; Slooter et al. 1998).”
Background
Susceptibility Locus for Alzheimer's Disease on Chromosome 10
Myers, A., Holmans, P., Marshall, H. N., Kwon, J. M., Meyer, D., Ramic, D., Shears, S., Booth, J., DeVriéze, F. W., Crook, R., et al. (2000) · Science · doi:10.1126/science.290.5500.2304 · Cited by 385 · see citing works
Frequency and distribution of Alzheimer's disease in Europe: A collaborative study of 1980–1990 prevalence findings
Rocca, W. A., Albert Hofman, D., Brayne, C., Breteler, M. M. B., Clarke, M., Copeland, J. R. M., Dartigues, J., Engedal, K., Hagnell, O., Heeren, T. J., et al. (1991) · Annals of Neurology · doi:10.1002/ana.410300310 · Cited by 384 · see citing works
Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells
Oka, K., Sawamura, T., Kikuta, K., Itokawa, S., Kume, N., Kita, T., & Masaki, Τ. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9535 · Cited by 383 · see citing works
Linkage of Plasma Aβ42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees
Ertekin‐Taner, N., Graff-Radford, N., Younkin, L. H., Eckman, C. B., Baker, M., Adamson, J. L., Ronald, J., Blangero, J., Hutton, M. L., & Younkin, S. G. (2000) · Science · doi:10.1126/science.290.5500.2303 · Cited by 370 · see citing works
A full genome scan for late onset Alzheimer's disease
Kehoe, P. G. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.2.237 · Cited by 356 · see citing works
Results of a high-resolution genome screen of 437 Alzheimer's Disease families
Blacker, D. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg007 · Cited by 344 · see citing works
A4POE*4-associated Alzheimer's disease risk is modified by α1–antichymotrypsin polymorphism
Kamboh, M. I., Sanghera, D. K., Ferrell, R. E., & DeKosky, S. T. (1995) · Nature Genetics · doi:10.1038/ng0895-486 · Cited by 336 · see citing works
Self-citation
APOE genotype predicts when — not whether — one is predisposed to develop Alzheimer disease
Meyer, M. R., Tschanz, J. T., Norton, M. C., Welsh-Bohmer, K. A., Steffens, D. C., Wyse, B. W., & Breitner, J. C. S. (1998) · Nature Genetics · doi:10.1038/1206 · Cited by 335 · see citing works
Age at Onset in Two Common Neurodegenerative Diseases Is Genetically Controlled
Li, Y.-J., Scott, W. K., Hedges, D. J., Zhang, F., Gaskell, P. C., Nance, M. A., Watts, R. L., Hubble, J. P., Koller, W. C., Pahwa, R., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/339815 · Cited by 312 · see citing works
The Number of Trait Loci in Late-Onset Alzheimer Disease
Daw, E. W., Payami, H., Nemens, E. J., Nochlin, D., Bird, T. D., Schellenberg, G. D., & Wijsman, E. M. (2000) · The American Journal of Human Genetics · doi:10.1086/302710 · Cited by 295 · see citing works
Multiple, diverse senile plaque–associated proteins are ligands of an apolipoprotein e receptor, the α2‐macroglobulin receptor/low‐density‐lipoprotein receptor—related protein
Rebeck, G. W., Harr, S. D., Hyman, B. T., & Strickland, D. K. (1995) · Annals of Neurology · doi:10.1002/ana.410370212 · Cited by 294 · see citing works
A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia
Bullido, M. J., Artiga, M. J., Recuero, M., Sastre, I., García, M., Aldudo, J., Lendon, C. L., Han, S. W., Morris, J. C., Frank, A., et al. (1998) · Nature Genetics · doi:10.1038/ng0198-69 · Cited by 286 · see citing works
Polygenic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder: the additive and subtractive effect of the three dopaminergic genes--DRD2, D beta H, and DAT1.
Comings, D., Wu, S., Chiu, C., Ring, R., Gade, R., Ahn, C., MacMurray, J. P., Dietz, G., & Muhleman, D. (1996) · American journal of medical genetics · doi:10.1002/(sici)1096-8628(19960531)67:3 · Cited by 283 · see citing works
Replication of Linkage Studies of Complex Traits: An Examination of Variation in Location Estimates
Roberts, S. B., MacLean, C. J., Neale, M. C., Eaves, L. J., & Kendler, K. S. (1999) · The American Journal of Human Genetics · doi:10.1086/302528 · Cited by 274 · see citing works
Alzheimer's Disease Care: Costs And Potential Savings
Leon, J., Cheng, C.-K., & Neumann, P. J. (1998) · Health Affairs · doi:10.1377/hlthaff.17.6.206 · Cited by 250 · see citing works
The Cholesterol Quartet
Goldstein, J. L., & Brown, M. S. (2001) · Science · doi:10.1126/science.1061815 · Cited by 242 · see citing works
Glutathione S-transferase omega-1 modifiesage-at-onset of Alzheimer disease and Parkinson disease
Li, Y. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg357 · Cited by 234 · see citing works
Oxidized LDL Modulates Bax/Bcl-2 Through the Lectinlike Ox-LDL Receptor-1 in Vascular Smooth Muscle Cells
Kataoka, H., Kume, N., Miyamoto, S., Minami, M., Morimoto, M., Hayashida, K., Hashimoto, N., & Kita, T. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.6.955 · Cited by 216 · see citing works
Full genome screen for Alzheimer disease: Stage II analysis*
Myers, A., DeVriéze, F. W., Holmans, P., Hamshere, M. L., Crook, R., Compton, D., Marshall, H. N., Meyer, D., Shears, S., Booth, J., et al. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10183 · Cited by 206 · see citing works
Complete Genomic Screen in Late-Onset Familial Alzheimer Disease: Evidence for a New Locus on Chromosome 12
Pericak-Vance, M. A. (1997) · JAMA · doi:10.1001/jama.1997.03550150041033 · Cited by 206 · see citing works
Identification of Novel Genes in Late-Onset Alzheimer's Disease
Pericak‐Vance, M. A., Grubber, J. M., Bailey, L., Hedges, D. J., West, S. G., Santoro, L., Kemmerer, B., Hall, J. L., Saunders, A. M., Roses, A. D., et al. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00196-0 · Cited by 195 · see citing works
Association between polymorphism in regulatory region of gene encoding tumour necrosis factor α and risk of Alzheimer's disease and vascular dementia: a case-control study
McCusker, S. M., Curran, M. D., Dynan, K., McCullagh, C. D., Urquhart, D., Middleton, D., Patterson, C. C., McIlroy, S. P., & Passmore, A. P. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04008-3 · Cited by 191 · see citing works
Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease
Okuizumi, K., Onodera, O., Namba, Y., Ikeda, K., Yamamoto, T. T., Seki, K., Ueki, A., Nanko, S., Tanaka, H., Takahashi, H., et al. (1995) · Nature Genetics · doi:10.1038/ng1095-207 · Cited by 183 · see citing works
Apolipoprotein E ε4 Allele and the Lifetime Risk of Alzheimer's Disease: What Physicians Know, and What They Should Know
Seshadri, S. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540350068018 · Cited by 163 · see citing works
The Fe65 Adaptor Protein Interacts through Its PID1 Domain with the Transcription Factor CP2/LSF/LBP1
Zambrano, N., Minopoli, G., de Candia, P., & Russo, T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20128 · Cited by 153 · see citing works
Evidence for an Alzheimer Disease Susceptibility Locus on Chromosome 12 and for Further Locus Heterogeneity
Rogaeva, E. A. (1998) · JAMA · doi:10.1001/jama.280.7.614 · Cited by 150 · see citing works
Independent association of an APOE gene promoter polymorphism with increased risk of myocardial infarction and decreased APOE plasma concentrations--the ECTIM Study
Lambert, J. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.1.57 · Cited by 147 · see citing works
Genetic Association of a Cystatin C Gene Polymorphism With Late-Onset Alzheimer Disease
Finckh, U. (2000) · Archives of Neurology · doi:10.1001/archneur.57.11.1579 · Cited by 142 · see citing works
Identification of multiple loci for Alzheimer disease in a consanguineous Israeli-Arab community
Farrer, L. A. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg037 · Cited by 133 · see citing works
Pronounced impact of Th1/E47cs mutation compared with -491 AT mutation on neural APOE gene expression and risk of developing Alzheimer's disease
Lambert, J. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.9.1511 · Cited by 132 · see citing works
How heritable is Alzheimer's disease late in life? Findings from Swedish twins
Pedersen, N. L., Gatz, M., Berg, S., & Johansson, B. E. A. (2003) · Annals of Neurology · doi:10.1002/ana.10999 · Cited by 131 · see citing works
Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis
Farrer, L. A. (1997) · JAMA · doi:10.1001/jama.1997.03550160069041 · Cited by 124 · see citing works
Fine Mapping of the Chromosome 12 Late-Onset Alzheimer Disease Locus: Potential Genetic and Phenotypic Heterogeneity
Scott, W. K., Grubber, J. M., Conneally, P. M., Small, G. W., Hulette, C. M., Rosenberg, C. K., Saunders, A. M., Roses, A. D., Haines, J. L., & Pericak‐Vance, M. A. (2000) · The American Journal of Human Genetics · doi:10.1086/302828 · Cited by 114 · see citing works
A polymorphism in the cystatin C gene is a novel risk factor for late-onset Alzheimer’s disease
Crawford, F., Freeman, M. J., Schinka, J. A., Abdullah, L. I., Gold, M., Hartman, R. D., Krivian, K., Morris, M. D., Richards, D., Duara, R., et al. (2000) · Neurology · doi:10.1212/wnl.55.6.763 · Cited by 109 · see citing works
Ordered-Subsets Linkage Analysis Detects Novel Alzheimer Disease Loci on Chromosomes 2q34 and 15q22
Scott, W. K., Hauser, E. R., Schmechel, D. E., Welsh-Bohmer, K. A., Small, G. W., Roses, A. D., Saunders, A. M., Gilbert, J. R., Vance, J. M., Haines, J. L., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/379083 · Cited by 104 · see citing works
Psychotic symptoms in Alzheimer disease: evidence for a distinct phenotype
Sweet, R. A., Nimgaonkar, V. L., Devlin, B., & Jeste, D. V. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001262 · Cited by 103 · see citing works
Heritability of factors of the insulin resistance syndrome in women twins
Edwards, K. L., Newman, B. M., Mayer, E. J., Selby, J. V., Krauss, R. M., & Austin, M. A. (1997) · Genetic Epidemiology · doi:10.1002/(sici)1098-2272(1997)14:3 · Cited by 101 · see citing works
Genetic Studies on Chromosome 12 in Late-Onset Alzheimer Disease
Wu, W. S. (1998) · JAMA · doi:10.1001/jama.280.7.619 · Cited by 100 · see citing works
A Genome Survey for Novel Alzheimer Disease Risk Loci: Results at 10-cM Resolution
Zubenko, G. S., Hughes, H. B., Stiffler, J. S., Hurtt, M. R., & Kaplan, B. B. (1998) · Genomics · doi:10.1006/geno.1998.5306 · Cited by 97 · see citing works
Genetic variation in a haplotype block spanningIDE influences Alzheimer disease
Prince, J. A., Feuk, L., Gu, H. F., Johansson, B. E. A., Gatz, M., Blennow, K., & Brookes, A. J. (2003) · Human Mutation · doi:10.1002/humu.10282 · Cited by 97 · see citing works
Genome-wide linkage disequilibrium mapping of late-onset Alzheimer’s disease in Finland
Hiltunen, M. O., Mannermaa, A., Thompson, D., Easton, D. F., Pirskanen, M. M., Helisalmi, S., Koivisto, A. M., Lehtovirta, M., Ryynänen, M., & Soininen, H. S. (2001) · Neurology · doi:10.1212/wnl.57.9.1663 · Cited by 97 · see citing works
Genetic variants in a haplotype block spanningIDE are significantly associated with plasma A?42 levels and risk for Alzheimer disease
Ertekin‐Taner, N., Allen, M., Fadale, D. J., Scanlin, L., Younkin, L. H., Petersen, R. C., Graff‐Radford, N. R., & Younkin, S. G. (2004) · Human Mutation · doi:10.1002/humu.20016 · Cited by 97 · see citing works
Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease
Abraham, R., Myers, A., Wavrant-DeVrièze, F., Hamshere, M. L., Thomas, H. V., Marshall, H. N., Compton, D., Spurlock, G., Turic, D., Hoogendoorn, B., et al. (2001) · Human Genetics · doi:10.1007/s00439-001-0614-1 · Cited by 95 · see citing works
Monogenic Dyslipidemias: Window on Determinants of Plasma Lipoprotein Metabolism
Hegele, R. A. (2001) · The American Journal of Human Genetics · doi:10.1086/324647 · Cited by 93 · see citing works
A Second Locus for Very-Late-Onset Alzheimer Disease: A Genome Scan Reveals Linkage to 20p and Epistasis between 20p and the Amyloid Precursor Protein Region
Olson, J. M., Goddard, K. A. B., & Dudek, D. M. (2002) · The American Journal of Human Genetics · doi:10.1086/341034 · Cited by 91 · see citing works
Alzheimer's disease : advances in etiology, pathogenesis, and therapeutics
Iqbal, K., Sisodia, S. S., Winblad, B. G., & Disorders, R. (2001) · Wiley eBooks · Cited by 89 · see citing works
No Genetic Effect of α1-Antichymotrypsin in Alzheimer Disease
Haines, J. L., Pritchard, M. L., Saunders, A. M., Schildkraut, J. M., Growdon, J. H., Gaskell, P. C., Farrer, L. A., Auerbach, S. H., Gusella, J. F., Locke, P. A., et al. (1996) · Genomics · doi:10.1006/geno.1996.0158 · Cited by 87 · see citing works
Evidence for association of HLA-A2 allele with onset age of Alzheimer's disease
Payami, H., Schellenberg, G. D., Zareparsi, S., Kaye, J. A., Sexton, G. J., Head, M. A., Matsuyama, S. S., Jarvik, L. F., Miller, B. L., McManus, D. Q., et al. (1997) · Neurology · doi:10.1212/wnl.49.2.512 · Cited by 84 · see citing works
Fine mapping of the -T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees
Ertekin-Taner, N. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg343 · Cited by 80 · see citing works
Molecular genetics of Alzheimerʼs disease: the role of β-amyloid and the presenilins
Tandon, A., Rogaeva, E. A., MULLAN, M. J., & George‐Hyslop, P. S. (2000) · Current Opinion in Neurology · doi:10.1097/00019052-200008000-00003 · Cited by 80 · see citing works
Association of late-onset Alzheimer disease with a genotype of PLAU, the gene encoding urokinase-type plasminogen activator on chromosome 10q22.2
Finckh, U., van Hadeln, K., Müller‐Thomsen, T., Alberici, A., Binetti, G. G., Hock, C., Nitsch, R. M., Stoppe, G., Reiss, J., & Gal, A. (2003) · Neurogenetics · doi:10.1007/s10048-003-0157-9 · Cited by 78 · see citing works
The transcriptional factor LBP-1c/CP2/LSF gene on chromosome 12 is a genetic determinant of Alzheimer's disease
Lambert, J., Goumidi, L., Vrièze, F. W., Frigard, B., Harris, J. M., Cummings, A., Coates, J., Pasquier, F., Cottel, D., Gaillac, M., et al. (2000) · Human Molecular Genetics · doi:10.1093/oxfordjournals.hmg.a018918 · Cited by 77 · see citing works
The Human Gene Encoding the Lectin-Type Oxidized LDL Receptor (OLR1) Is a Novel Member of the Natural Killer Gene Complex with a Unique Expression Profile
Yamanaka, S., Zhang, X., Miura, K., Kim, S., & Iwao, H. (1998) · Genomics · doi:10.1006/geno.1998.5561 · Cited by 76 · see citing works
Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin
Saunders, A. J. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg310 · Cited by 72 · see citing works
Major Recessive Gene(s) with Considerable Residual Polygenic Effect Regulating Adult Height: Confirmation of Genomewide Scan Results for Chromosomes 6, 9, and 12
Xu, J., Bleecker, E. R., Jongepier, H., Howard, T. D., Koppelman, G. H., Postma, D. S., & Meyers, D. A. (2002) · The American Journal of Human Genetics · doi:10.1086/342216 · Cited by 69 · see citing works
Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease
Boussaha, M., Hannequin, D., Verpillat, P., Brice, A., Frébourg, T., & Campion, D. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00586-4 · Cited by 68 · see citing works
Molecular misreading: a new type of transcript mutation expressed during aging
van Leeuwen, F. W. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00151-2 · Cited by 68 · see citing works
Chromosome-12 Mapping of Late-Onset Alzheimer Disease among Caribbean Hispanics
Mayeux, R. P., Lee, J. H., Romas, S. N., Mayo, D., Santana, V., Williamson, J., Ciappa, A., Rondon, H. Z., Estevez, P., Lantigua, R., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/324773 · Cited by 67 · see citing works
Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: evidence of effect modification by apolipoprotein E (APOE)
Edland, S. D., Vriesé, F. W.-D., Compton, D. M., Smith, G. E., Ivnik, R. J., Boeve, B. F., Tangalos, E. G., & Petersen, R. C. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00488-9 · Cited by 64 · see citing works
The Amyloid Precursor Protein Locus and Very-Late-Onset Alzheimer Disease
Olson, J. M., Goddard, K. A. B., & Dudek, D. M. (2001) · The American Journal of Human Genetics · doi:10.1086/323472 · Cited by 64 · see citing works
Alzheimer’s disease and the cystatin C gene polymorphism: an association study
Beyer, K., Lao, J. I., Gómez, M., Riutort, N., Latorre, P., Mate, J. L., & Ariza, A. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02307-2 · Cited by 64 · see citing works
Association of the 3′ UTR transcription factor LBP‐1c/CP2/LSF polymorphism with late‐onset Alzheimer's disease
Luedecking‐Zimmer, E., DeKosky, S. T., Nebes, R. D., & Kamboh, M. I. (2002) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.10026 · Cited by 63 · see citing works
Self-citation
Linkage analysis of Alzheimer disease with psychosis
Bacanu, S., Devlin, B., Chowdari, K. V., DeKosky, S. T., Nimgaonkar, V. L., & Sweet, R. A. (2002) · Neurology · doi:10.1212/wnl.59.1.118 · Cited by 60 · see citing works
Alzheimer's disease and apolipoprotein e‐4 allele in an amish population
Pericak‐Vance, M. A., Johnson, C. C., Rimmler, J. B., Saunders, A. M., Robinson, L. C., D'Hondr, E. G., Jackson, C. E., & Haines, J. L. (1996) · Annals of Neurology · doi:10.1002/ana.410390605 · Cited by 60 · see citing works
The α2-macroglobulin gene in AD
Koster, M. N., Dermaut, B., Cruts, M., Houwing‐Duistermaat, J. J., Roks, G., Tol, J., Ott, A., Albert Hofman, D., Munteanu, G., Breteler, M. M. B., et al. (2000) · Neurology · doi:10.1212/wnl.55.5.678 · Cited by 58 · see citing works
Candidate genes showing no evidence for association or linkage with Alzheimer's disease using family-based methodologies
Bertram, L., Blacker, D., Crystal, A., Mullin, K., Keeney, D. B., Jones, J. L., Basu, S., Yhu, S., Guénette, S. Y., McInnis, M. G., et al. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00193-5 · Cited by 58 · see citing works
Fine mapping of 10q and 18q for familial Alzheimer's disease in Caribbean Hispanics
Lee, J. H., Mayeux, R. P., Mayo, D., Mo, J., Santana, V., Williamson, J., Flaquer, A., Ciappa, A., Rondon, H. Z., Estevez, P., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001538 · Cited by 53 · see citing works
TNF gene polymorphism and its relation to intracerebral production of TNFα and TNFβ in AD
Tarkowski, E., Liljeroth, A., Nilsson, A. M., Ricksten, A., Davidsson, P., Minthon, L., & Blennow, K. (2000) · Neurology · doi:10.1212/wnl.54.11.2077 · Cited by 53 · see citing works
Absence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE.
Song, Y.-Q., Rogaeva, E., Premkumar, S., Brindle, N., Kawarai, T., Orlacchio, A., Yu, G., Lévesque, G., Nishimura, M., Ikeda, M., et al. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00470-4 · Cited by 52 · see citing works
Investigation of oxidized LDL-receptor 1 (OLR1) as the candidate gene for Alzheimer's disease on chromosome 12
Luedecking‐Zimmer, E., DeKosky, S. T., Chen, Q., Barmada, M. M., & Kamboh, M. I. (2002) · Human Genetics · doi:10.1007/s00439-002-0802-7 · Cited by 48 · see citing works
Self-citation
Association of 3′-UTR polymorphisms of the oxidised LDL receptor 1 (OLR1) gene with Alzheimer’s disease
Lambert, J., Luedecking‐Zimmer, E., Merrot, S., Hayes, A., Thaker, U., Desai, P., Houzet, A., Hermant, X., Cottel, D., Pritchard, A. L., et al. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.6.424 · Cited by 46 · see citing works
Self-citation
Lack of an association between cystatin C gene polymorphisms in Japanese patients with Alzheimer’s disease
Maruyama, H., Izumi, Y., Oda, M., Torii, T., Morino, H., Toji, H., Sasaki, K., Terasawa, H., Nakamura, S., & Kawakami, H. (2001) · Neurology · doi:10.1212/wnl.57.2.337 · Cited by 46 · see citing works
Apolipoprotein E promoter polymorphism and sporadic Alzheimer's disease in a Japanese population
Toji, H., Maruyama, H., Sasaki, K., Nakamura, S., & Kawakami, H. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00855-6 · Cited by 44 · see citing works
HLA-DR antigens associated with major genetic risk for late-onset Alzheimerʼs disease
Curran, M. D., Middleton, D., Edwardson, J. A., Perry, R. H., McKeith, I. G., Morris, C. M., & Neill, D. (1997) · Neuroreport · doi:10.1097/00001756-199704140-00028 · Cited by 43 · see citing works
Genetic variation in α1-antichymotrypsin and its association with Alzheimer’s disease
Wang, X., DeKosky, S. T., Luedecking‐Zimmer, E., Ganguli, M., & Kamboh, M. I. (2002) · Human Genetics · doi:10.1007/s00439-002-0697-3 · Cited by 41 · see citing works
Self-citation
Purification and Characterization of the Serum Amyloid A3 Enhancer Factor
Bing, Z., Reddy, S. A. G., Ren, Y., Liao, W. S. ‐., & Qin, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.24649 · Cited by 40 · see citing works
Genetic variability at the amyloid-β precursor protein locus may contribute to the risk of late-onset Alzheimer's disease
Vrièze, F. W., Crook, R., Holmans, P., Kehoe, P. G., Owen, M. J., Williams, J. H., Roehl, K., Lahiri, D. K., Shears, S., Booth, J., et al. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00417-6 · Cited by 40 · see citing works
Identification of a single nucleotide polymorphism in the choline acetyltransferase gene associated with Alzheimer's disease
Mubumbila, V., Sutter, A., Ptok, U., Heun, R., & Quirin‐Stricker, C. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00955-2 · Cited by 40 · see citing works
A novel mutation in the apolipoprotein E gene (APOE*4 Pittsburgh) is associated with the risk of late-onset Alzheimer's disease
Kamboh, M. I., Aston, C. E., Perez-Tur, J., Kokmen, E., Ferrell, R. E., Hardy, J., & DeKosky, S. T. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00129-9 · Cited by 40 · see citing works
Self-citation
Very low density lipoprotein receptor binds apolipoprotein E2/2 as well as apolipoprotein E3/3
Takahashi, S., Oida, K., Ookubo, M., Suzuki, J., Kohno, M., Murase, T., Yamamoto, T. T., & NAKAI, T. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00439-5 · Cited by 39 · see citing works
The very high prevalence of AD in an Arab population is not explained by APOE ε4 allele frequency
Bowirrat, A., Friedland, R. P., Chapman, J., & Korczyn, A. D. (2000) · Neurology · doi:10.1212/wnl.55.5.731 · Cited by 38 · see citing works
Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease
Harold, D. H., Peirce, T., Moskvina, V., Lovestone, S., Powell, J. F., Foy, C., Archer, N. J., Walter, S., Edmonson, A., McIlroy, S. P., et al. (2003) · Human Genetics · doi:10.1007/s00439-003-0960-2 · Cited by 38 · see citing works
Lack of association of very low density lipoprotein receptor gene polymorphism with caucasian Alzheimer's disease
Okuizumi, K., Onodera, O., Tanaka, H., Tsuji, S., Seki, K., Namba, Y., Ikeda, K., Saunders, A. M., Pericak‐Vance, M. A., & Roses, A. D. (1996) · Annals of Neurology · doi:10.1002/ana.410400220 · Cited by 38 · see citing works
HLA‐A2, or a closely linked gene, confers susceptibility to early‐onset sporadic Alzheimer's disease in men
Payami, H., Kaye, J. A., Becker, W. C., Norman, D. J., & Wetzsteon, P. J. (1991) · Neurology · doi:10.1212/wnl.41.10.1544 · Cited by 34 · see citing works
Chromosome 12 and late-onset Alzheimer's disease
Poduslo, S. E., & Yin, X. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02130-9 · Cited by 33 · see citing works
Genetic association of anLBP-1c/CP2/LSFgene polymorphism with late onset Alzheimer's disease: Table 1
Taylor, A., Yip, A. G., Brayne, C., Easton, D., Evans, J. G., Xuereb, J., Cairns, N., Esiri, M. M., & Rubinsztein, D. C. (2001) · Journal of Medical Genetics · doi:10.1136/jmg.38.4.232 · Cited by 33 · see citing works
No association between very low density lipoprotein receptor (VLDL-R) and Alzheimer disease in American Caucasians
Pritchard, M. L., Saunders, A. M., Gaskell, P. C., Small, G. W., Conneally, P. M., Rosi, B. L., Yamaoka, L. H., Roses, A. D., Haines, J. L., & Pericak‐Vance, M. A. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12630-6 · Cited by 31 · see citing works
Lack of association between a single nucleotide polymorphism within the choline acetyltransferase gene and patients with Alzheimer's disease
Schwarz, S., Eisele, T., Diehl, J., Müller, U., Förstl, H., Kurz, A., & Riemenschneider, M. J. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00380-x · Cited by 28 · see citing works
Lack of association of trinucleotide repeat polymorphisms in the very‐low‐density lipoprotein receptor gene with Alzhelner's disease
Ba, H. C., Roberts, C. T., Greenberg, S. M., Rebeck, G. W., Bs, R. C., Wallace, R. B., Jacob, H. J., & Hyman, B. T. (1996) · Annals of Neurology · doi:10.1002/ana.410390617 · Cited by 27 · see citing works
Genetic variation in CTNNA3 encoding alpha-3 catenin and Alzheimer's disease
Blomqvist, M. E.-L., Andreasen, N., Bogdanović, N., Blennow, K., Brookes, A. J., & Prince, J. A. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.01.032 · Cited by 27 · see citing works
No association between the insulin degrading enzyme gene and Alzheimer's disease in a Japanese population
Sakai, A., Ujike, H., Nakata, K., Takehisa, Y., Imamura, T., Uchida, N., Kanzaki, A., Yamamoto, M., Fujisawa, Y., Okumura, K., et al. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20106 · Cited by 27 · see citing works
Gene expression profiles: Creating new perspectives in arthritis research
Grant, E. P., Pickard, M. D., Briskin, M., & Gutierrez-Ramos, J.-C. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10014 · Cited by 27 · see citing works
Lack of association between α2-macroglobulin polymorphisms and Alzheimer's disease
Wang, X., Luedecking‐Zimmer, E., Minster, R. L., Ganguli, M., DeKosky, S. T., & Kamboh, M. I. (2001) · Human Genetics · doi:10.1007/s004390000445 · Cited by 25 · see citing works
Self-citation
Variation in the urokinase‐plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD
Myers, A., Marshall, H. N., Holmans, P., Compton, D., Crook, R., Mander, A., Nowotny, P., Smemo, S., Dunstan, M. L., Jehu, L., et al. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20036 · Cited by 24 · see citing works
Allelic association between the D10S1423 marker and Alzheimer's disease in a German population
Majores, M., Bagli, M., Papassotiropoulos, A., Schwab, S. G., Jessen, F., Rao, M. L., Maier, W., & Heun, R. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01283-0 · Cited by 23 · see citing works
Computerized self‐assessment in psychiatric in‐patients: acceptability, feasibility and influence of computer attitude
Weber, B., Fritze, J., Schneider, B., Simminger, D., & Maurer, K. (1998) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1998.tb10056.x · Cited by 22 · see citing works
Short communication Association of the HLA-A2 allele with an earlier age of onset of Alzheimer's disease
Combarros, O., Escribano, J., Sánchez‐Velasco, P., Leyva‐Cobián, F., Oterino, A., Leno, C., & Berciano, J. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1998.tb01735.x · Cited by 21 · see citing works
Frequency of HLA-A and B alleles in early and late-onset Alzheimer's disease
Middleton, D., Mawhinney, H., Curran, M. D., Edwardson, J. A., Perry, R., McKeith, I. G., Morris, C. M., Ince, P. G., & Neill, D. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00045-2 · Cited by 20 · see citing works
An HLA and family study of Alzheimer's disease
Renvoize, E. B. (1984) · Psychological Medicine · doi:10.1017/s0033291700015117 · Cited by 16 · see citing works
No association between a previously reported OLR1 3′ UTR polymorphism and Alzheimer’s disease in a large family sample
Bertram, L., Parkinson, M., Mullin, K., Menon, R., Blacker, D., & Tanzi, R. E. (2004) · Journal of Medical Genetics · doi:10.1136/jmg.2003.016980 · Cited by 16 · see citing works
No association detected between very-low-density lipoprotein receptor (VLDL-R) and late-onset Alzheimer's disease in Hong Kong Chinese
Chen, L., Baum, L., Ng, H., Chan, Y. S., Mak, Y. T., Woo, J., Chiu, H. F. K., & Pang, C. P. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00975-0 · Cited by 12 · see citing works
The 5-repeat allele in the very-low-density lipoprotein receptor gene polymorphism is not increased in sporadic Alzheimer's disease in Japanese
Arinami, T., Takekoshi, K., Yanagi, H., Hamamoto, M., & Hamaguchi, H. (1996) · Neurology · doi:10.1212/wnl.47.5.1349 · Cited by 11 · see citing works
A Genomic Search for Alzheimer's Disease Genes
Haines, J. L., Bailey, L., Grubber, J. M., Hedges, D. J., Hall, J. L., West, S. G., Santoro, L., Kemmerer, B., Saunders, A. M., Roses, A. D., et al. (2001) · doi:10.1002/0470846453.ch4 · Cited by 8 · see citing works
No evidence of association between the D10S1423 locus and Alzheimer disease in Brazilian patients
Nishimura, A. L., Oliveira, J. R. M., Otto, P. A., Matioli, S. R., de Brito-Marques, P. R., Bahia, V. S., Nitríni, R., & Zatz, M. (2001) · Journal of Neural Transmission · doi:10.1007/s007020170076 · Cited by 6 · see citing works
No association between marker D10S1423 and Alzheimer's disease
Bertram, L., Saunders, A. J., Mullin, K., Sampson, A. J., Moscarillo, T. J., Basset, S. S., Go, R. C. P., Blacker, D., & Tanzi, R. E. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001355 · Cited by 2 · see citing works
Expression profiling and comparative sequence derived insights into lipid metabolism
Callow, M. J., & Rubin, E. M. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200204000-00009 · Cited by 2 · see citing works
Untitled work
Jonnal (2000) · doi:10.1002/1096-8628(20001204)96:6
Untitled work
Price (1999) · doi:10.1002/1531-8249(199903)45:3

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Review Article: Genetics of Alzheimer Disease
Bekris, L. M., Yu, C.-E., Bird, T. D., & Tsuang, D. W. (2010) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988710383571 · Cited by 1,029 · see citing works
Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction
Devi, L., Prabhu, B. M., Galati, D. F., Avadhani, N. G., & Anandatheerthavarada, H. K. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1469-06.2006 · Cited by 792 · see citing works
Epigenetic mechanisms in neurogenesis
Yao, B., Christian, K. M., He, C., Jin, P., Ming, G., & Song, H. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.70 · Cited by 392 · see citing works
Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice
Pedersen, W. A., McMillan, P. J., Kulstad, J. J., Leverenz, J. B., Craft, S., & Haynatzki, G. R. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.01.018 · Cited by 321 · see citing works
Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases
Migliore, L., & Coppedè, F. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.10.011 · Cited by 319 · see citing works
Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer’s disease
Chin, J., Palop, J. J., Puoliväli, J., Massaro, C., Bien-Ly, N., Gerstein, H., Scearce-Levie, K., Masliah, E., & Mucke, L. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2980-05.2005 · Cited by 312 · see citing works
Modulatory Neurotransmitter Systems and Behavior: Towards Zebrafish Models of Neurodegenerative Diseases
Panula, P., Sallinen, V. J., Sundvik, M., Kolehmainen, J., Torkko, V., Tiittula, A., Moshnyakov, M., & Podlasz, P. (2006) · Zebrafish · doi:10.1089/zeb.2006.3.235 · Cited by 296 · see citing works
Assessment of disease-related cognitive impairments using the novel object recognition (NOR) task in rodents
Grayson, B., Léger, M., Piercy, C., Adamson, L., Harte, M., & Neill, J. C. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.10.025 · Cited by 246 · see citing works
MicroRNA Expression in Alzheimer Blood Mononuclear Cells
Schipper, H. M., Maes, O. C., Chertkow, H. M., & Wang, E. (2007) · Gene Regulation and Systems Biology · doi:10.4137/grsb.s361 · Cited by 244 · see citing works
Genetics of Alzheimer's Disease: A Centennial Review
Ertekin‐Taner, N. (2007) · Neurologic Clinics · doi:10.1016/j.ncl.2007.03.009 · Cited by 233 · see citing works
In vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer's Disease
Watt, G., & Karl, T. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00020 · Cited by 227 · see citing works
Sex Hormones and Cognition: Neuroendocrine Influences on Memory and Learning
Hamson, D. K., Roes, M., & Galea, L. A. M. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150031 · Cited by 205 · see citing works
Mitochondrial trafficking of APP and alpha synuclein: Relevance to mitochondrial dysfunction in Alzheimer's and Parkinson's diseases
Devi, L., & Anandatheerthavarada, H. K. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.07.007 · Cited by 150 · see citing works
Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family
Li, Y., Nowotny, P., Holmans, P., Smemo, S., Kauwe, J. S. K., Hinrichs, A. L., Tacey, K. M., Doil, L. M., van Luchene, R., Garcia, V., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403535101 · Cited by 139 · see citing works
Biological function and clinical relevance of chromogranin A and derived peptides
D’Amico, M. A., Ghinassi, B., Izzicupo, P., Manzoli, L., & Baldassarre, A. D. (2014) · Endocrine Connections · doi:10.1530/ec-14-0027 · Cited by 138 · see citing works
Evidence for Sub-Haplogroup H5 of Mitochondrial DNA as a Risk Factor for Late Onset Alzheimer's Disease
Santoro, A., Balbi, V., Balducci, E., Pirazzini, C., Rosini, F., Tavano, F., Achilli, A., Siviero, P., Minicuci, N., Bellavista, E., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012037 · Cited by 134 · see citing works
Genetics of Alzheimer's disease.
Alonso-Vilatela, M., López-López, M., & Yescas-Gómez, P. (2012) · Archives of Medical Research · doi:10.1016/j.arcmed.2012.10.017 · Cited by 78 · see citing works
Pathophysiology of Alzheimer's Disease
Imbimbo, B. P., Lombard, J., & Pomara, N. (2005) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2005.09.009 · Cited by 133 · see citing works
Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study
Lee, J. H., Cheng, R., Graff-Radford, N., Foroud, T., & Mayeux, R. (2008) · Archives of Neurology · doi:10.1001/archneur.65.11.1518 · Cited by 132 · see citing works
Genetic Factors in Alzheimer's Disease
Bird, T. D. (2005) · New England Journal of Medicine · doi:10.1056/nejmp058027 · Cited by 122 · see citing works
Environmental and dietary risk factors in Alzheimer’s disease
Dosunmu, R., Wu, J., Basha, R. M., & Zawia, N. H. (2007) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.7.7.887 · Cited by 109 · see citing works
Cannabidiol for neurodegenerative disorders: A comprehensive review
Bhunia, S., Kolishetti, N., Yndart, A., Vashist, A., & Nair, M. G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.989717 · Cited by 115 · see citing works
Association of Low-Level Ozone with Cognitive Decline in Older Adults
Cleary, E. G., Cifuentes, M., Grinstein, G., Brugge, D., & Shea, T. B. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170658 · Cited by 105 · see citing works
Expression of normal sequence pathogenic proteins for neurodegenerative disease contributes to disease risk: ‘permissive templating’ as a general mechanism underlying neurodegeneration
Hardy, J. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330578 · Cited by 105 · see citing works
Genetics of Alzheimer's Disease. A Rapidly Evolving Field
Serretti, A., Olgiati, P., & Ronchi, D. D. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-12108 · Cited by 103 · see citing works
Common Inflammatory Mechanisms in Lewy Body Disease and Alzheimer Disease
Mrak, R. E., & Griffin, W. S. T. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31812503e1 · Cited by 86 · see citing works
Association between APOE ε4 Allele and Vascular Dementia: The Cache County Study
Chuang, Y.-F., Hayden, K. M., Norton, M. C., Tschanz, J., Breitner, J. C. S., Welsh-Bohmer, K. A., Zandi, P. P., & for the Cache County Investigators (2010) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000285166 · Cited by 81 · see citing works
The Contribution of Genetic Factors to Cognitive Impairment and Dementia: Apolipoprotein E Gene, Gene Interactions, and Polygenic Risk
Fan, J., Tao, W., Li, X., Li, H., Zhang, J., Wei, D., Chen, Y., & Zhang, Z. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051177 · Cited by 83 · see citing works
Less efficient pattern separation may contribute to age-related spatial memory deficits
Holden, H. M., & Gilbert, P. E. (2012) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2012.00009 · Cited by 77 · see citing works
Genetic heterogeneity of Alzheimer's disease: Complexity and advances
Lambert, J., & Amouyel, P. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.05.015 · Cited by 78 · see citing works
The therapeutic potential of the phytocannabinoid cannabidiol for Alzheimer’s disease
Karl, T., Garner, B., & Cheng, D. (2016) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000247 · Cited by 78 · see citing works
Genomics and Functional Genomics of Alzheimer's Disease
Kamboh, M. I. (2022) · Neurotherapeutics · doi:10.1007/s13311-021-01152-0 · Cited by 73 · see citing works
Self-citation
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Dietary Supplementation with S-Adenosyl Methionine Delayed Amyloid-β and Tau Pathology in 3xTg-AD Mice
Lee, S., Lemere, C. A., Frost, J. L., & Shea, T. B. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111025 · Cited by 68 · see citing works
Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer’s disease
Jackson, H. M., Soto, I., Graham, L. C., Carter, G. W., & Howell, G. R. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-831 · Cited by 66 · see citing works
Interleukin 18 gene polymorphisms predict risk and outcome of Alzheimer's disease
Bossù, P., Ciaramella, A., Moro, M. L., Bellincampi, L., Bernardini, S., Federici, G., Trequattrini, A., Macciardi, F. M., Spoletini, I., Iulio, F. D., et al. (2007) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.103242 · Cited by 64 · see citing works
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Kamboh, M. I., Minster, R. L., Feingold, E., & DeKosky, S. T. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001775 · Cited by 62 · see citing works
Self-citation
Alzheimer’s Disease – The Past, the Present and the Future
Botchway, B. O. A. (2017) · Science Journal of Clinical Medicine · doi:10.11648/j.sjcm.20170601.11 · Cited by 60 · see citing works
Overrepresentation of Glutamate Signaling in Alzheimer's Disease: Network-Based Pathway Enrichment Using Meta-Analysis of Genome-Wide Association Studies
Pérez‐Palma, E., Bustos, B. I., Villamán, C., Alarcón, M. A., Ávila, M. E., Ugarte, G. D., Reyes, A. E., Opazo, C., Ferrari, G. V. D., Initiative, T. A. D. N., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095413 · Cited by 60 · see citing works
Investigation of the effect of brain-derived neurotrophic factor (BDNF) polymorphisms on the risk of late-onset Alzheimer's disease (AD) and quantitative measures of AD progression
Desai, P. P., Nebes, R. D., DeKosky, S. T., & Kamboh, M. I. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.01.008 · Cited by 60 · see citing works
Self-citation
Granins as disease-biomarkers: translational potential for psychiatric and neurological disorders
Bartolomucci, A., Pasinetti, G. M., & Salton, S. R. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.057 · Cited by 61 · see citing works
Evidence for induction of the ornithine transcarbamylase expression in Alzheimer's disease
Bensemain, F., Hot, D., Ferreira, S., Dumont, J., Bombois, S., Maurage, C.-A., Huot, L., Hermant, X., Levillain, E., Hubans, C., et al. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002089 · Cited by 58 · see citing works
Novel behavioural characteristics of female APPSwe/PS1ΔE9 double transgenic mice
Cheng, D., Low, J. K., Logge, W., Garner, B., & Karl, T. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.11.046 · Cited by 55 · see citing works
Risk and protective factors for sporadic Alzheimer's disease.
Stožická, Z., Žilka, N., & Novák, M. (2007) · PubMed · Cited by 55 · see citing works
Protein Tyrosine Phosphatase 1B (PTP1B): A Comprehensive Review of Its Role in Pathogenesis of Human Diseases
Kołodziej, D., Sobczak, Ł., & Łączkowski, K. Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137033 · Cited by 57 · see citing works
Apolipoprotein E υ4 Allele Frequency in Vascular Dementia
Davidson, Y. S., Gibbons, L., Purandare, N. B., Byrne, E. J., Hardicre, J., Wren, J., Payton, A., Pendleton, N., Horan, M. A., Burns, A. S., et al. (2006) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000092960 · Cited by 53 · see citing works
Age‐Related Inflammatory Diseases
Candore, G., Balistreri, C. R., Grimaldi, M. P., Vasto, S., Listı̀, F., Chiappelli, M., Licastro, F., Lio, D., & Caruso, C. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1386.008 · Cited by 52 · see citing works
Meta-analysis of APOE genotype and subarachnoid hemorrhage
Lanterna, L. A., Ruigrok, Y. M., Alexander, S. A., Tang, J., Biroli, F., Dunn, L., & Poon, W. S. (2007) · Neurology · doi:10.1212/01.wnl.0000267640.03300.6b · Cited by 52 · see citing works
Dementia with Lewy bodies: Definition, diagnosis, and pathogenic relationship to Alzheimer’s disease
Mrak, R. E., & Griffin, W. S. T. (2007) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.a936 · Cited by 49 · see citing works
Early Molecular Changes in Alzheimer Disease: Can We Catch the Disease in its Presymptomatic Phase?
Wirz, K. T. S., Keitel, S., Swaab, D. F., Verhaagen, J., & Bossers, K. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130920 · Cited by 47 · see citing works
S-Adenosyl Methionine: A Natural Therapeutic Agent Effective Against Multiple Hallmarks and Risk Factors Associated with Alzheimer's Disease
Shea, T. B., & Chan, A. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13107 · Cited by 47 · see citing works
To die or not to die: DNA repair in neurons
McMurray, C. T. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.03.006 · Cited by 46 · see citing works
Combined Effect of Apolipoprotein E Genotype and Past Fertility on Age at Onset of Alzheimer’s Disease in Women
Corbo, R. M., Gambina, G., Ulizzi, L., Monini, P., Broggio, E., Rosano, A., & Scacchi, R. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000103866 · Cited by 43 · see citing works
Genome scan on Swedish Alzheimer's disease families
Sillén, A., Forsell, C., Lilius, L., Axelman, K., Björk, B. F., Onkamo, P., Kere, J., Winblad, B. G., & Graff, C. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001772 · Cited by 42 · see citing works
Genetic variation in the choline acetyltransferase (CHAT) gene may be associated with the risk of Alzheimer's disease
Öztürk, A., DeKosky, S. T., & Kamboh, M. I. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.08.024 · Cited by 41 · see citing works
Self-citation
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Ryman, D. C., Gao, Y., & Lamb, B. T. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.02.017 · Cited by 41 · see citing works
Early biomarkers for post-stroke cognitive impairment
Qian, L., Ding, L., Cheng, L., Zhu, X., Zhao, H., Jin, J., Guan, D.-N., Zhang, B., Chen, X., & Xu, Y. (2012) · Journal of Neurology · doi:10.1007/s00415-012-6465-y · Cited by 40 · see citing works
Genome-wide analysis identifies novel loci influencing plasma apolipoprotein E concentration and Alzheimer’s disease risk
Aslam, M. M., Fan, K.-H., Lawrence, E., Bedison, M. A., Snitz, B. E., DeKosky, S. T., Lopez, O. L., Feingold, E., & Kamboh, M. I. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02170-4 · Cited by 39 · see citing works
Self-citation
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Li, C., Ebrahimi, A., & Schluesener, H. J. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.09.002 · Cited by 39 · see citing works
Advances on the Understanding of the Origins of Synaptic Pathology in AD
Lacor, P. N. (2007) · Current Genomics · doi:10.2174/138920207783769530 · Cited by 38 · see citing works
Transcriptional and epigenetic phenomena in peripheral blood cells of monozygotic twins discordant for alzheimer’s disease, a case report
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ABCA1 polymorphisms and Alzheimer's disease
Vrièze, F. W., Compton, D., Womick, M., Arepalli, S., Adighibe, O., Li, L., Pérez‐Tur, J., & Hardy, J. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.02.010 · Cited by 34 · see citing works
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Lee, J. H., Cheng, R., Santana, V., Williamson, J., Lantigua, R., Medrano, M. A., Arriaga, A., Stern, Y., Tycko, B., Rogaeva, E. A., et al. (2006) · Archives of Neurology · doi:10.1001/archneur.63.11.1591 · Cited by 34 · see citing works
Further evidence of a maternal parent‐of‐origin effect on chromosome 10 in late‐onset Alzheimer's disease
Bassett, S. S., Avramopoulos, D., Perry, R. T., Wiener, H. W., Watson, B., Go, R. C. P., & Fallin, M. D. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30350 · Cited by 33 · see citing works
Association study of the paraoxonase 1 gene with the risk of developing Alzheimer's disease
Chapuis, J., Boscher, M., Bensemain, F., Cottel, D., Amouyel, P., & Lambert, J. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.05.021 · Cited by 32 · see citing works
Emerging Alzheimer’s disease therapeutics: promising insights from lipid metabolism and microglia-focused interventions
Tobeh, N. S., & Bruce, K. D. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1259012 · Cited by 31 · see citing works
Differential Expression and miRNA–Gene Interactions in Early and Late Mild Cognitive Impairment
Brito, L. M., Ribeiro‐dos‐Santos, Â., Vidal, A. F., & de Araújo, G. S. (2020) · Biology · doi:10.3390/biology9090251 · Cited by 30 · see citing works
Age-at-onset linkage analysis in Caribbean Hispanics with familial late-onset Alzheimer’s disease
Lee, J. H., Barral, S., Cheng, R., Chacon, I. J., Santana, V., Williamson, J., Lantigua, R., Medrano, M., Velázquez, I. J., Stern, Y., et al. (2008) · Neurogenetics · doi:10.1007/s10048-007-0103-3 · Cited by 29 · see citing works
Apolipoprotein gene E4 allele promoter polymorphisms as risk factors for Alzheimer??s disease
Parker, G. R., Cathcart, H. M., Huang, R., Lanham, I. S., Corder, E. H., & Poduslo, S. E. (2005) · Psychiatric Genetics · doi:10.1097/00041444-200512000-00009 · Cited by 29 · see citing works
Mitochondrial Translocation of Amyloid Precursor Protein and its Cleaved Products: Relevance to Mitochondrial Dysfunction in Alzheimer's Disease
Anandatheerthavarada, H. K., & Devi, L. (2007) · Reviews in the Neurosciences · doi:10.1515/revneuro.2007.18.5.343 · Cited by 28 · see citing works
Association study and meta-analysis of low-density lipoprotein receptor related protein in Alzheimer's disease
Pritchard, A. L., Harris, J. M., Pritchard, C. W., Clair, D. S., Lemmon, H. A., Lambert, J., Chartier‐Harlin, M., Hayes, A., Thaker, U., Iwatsubo, T., et al. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.03.016 · Cited by 29 · see citing works
Children of Persons With Alzheimer Disease
Jarvik, L. F., LaRue, A. A., Blacker, D., Gatz, M., Kawas, C. H., McArdle, J. J., Morris, J. C., Mortimer, J. A., Ringman, J. M., Ercoli, L. M., et al. (2008) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31816653ac · Cited by 28 · see citing works
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Kunoh, S., Nakashima, H., & Nakashima, K. (2024) · Epigenomes · doi:10.3390/epigenomes8020022 · Cited by 29 · see citing works
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Lambert, J., Bensemain, F., Chapuis, J., Cottel, D., & Amouyel, P. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.04.010 · Cited by 26 · see citing works
Alzheimer's disease: epidemiology
Mayeux, R. P. (2008) · Handbook of clinical neurology · doi:10.1016/s0072-9752(07)01218-3 · Cited by 25 · see citing works
Risk Factors for Dementia in a Senegalese Elderly Population Aged 65 Years and Over
Toure, K., Coumé, M., Ndiaye, M. M., Zunzunegui, M. V., Bacher, Y., Diop, A. G., & Ndiaye, M. (2012) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000332022 · Cited by 24 · see citing works
Association of DAPK1 genetic variations with Alzheimer's disease in Han Chinese
Wu, Z., Zhang, W., Yu, J., Zhang, Q., Tian, Y., Lu, R.-C., Yu, N., Zhao-fu, C., & Tan, L. (2010) · Brain Research · doi:10.1016/j.brainres.2010.12.036 · Cited by 24 · see citing works
Association studies of transforming growth factor‐β1 and Alzheimer's disease
Dickson, M. R., Perry, R. T., Wiener, H. W., & Go, R. C. P. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30218 · Cited by 24 · see citing works
Current knowledge of chromosome 12 susceptibility genes for late-onset Alzheimer's disease
D’Introno, A., Solfrizzi, V., Colacicco, A. M., Capurso, C., Amodio, M., Todarello, O., Capurso, A., Kehoe, P. G., & Panza, F. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.020 · Cited by 23 · see citing works
Nutrition and Dementia: Are we Asking the Right Questions?
Shea, T. B., Rogers, E. J., & Remington, R. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-112231 · Cited by 23 · see citing works
Subarachnoid hemorrhage: tests of association with apolipoprotein E and elastin genes
Kaushal, R. D., Woo, D., Pal, P., Haverbusch, M. A., Xi, H., Moomaw, C. J., Sekar, P., D, B. M. K. M., Kleindorfer, D., Flaherty, M. L., et al. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-49 · Cited by 23 · see citing works
A 3’-UTR polymorphism in the oxidized LDL receptor 1 gene increases Aβ40 load as cerebral amyloid angiopathy in Alzheimer’s disease
Shi, J., Tian, J., Pritchard, A. L., Lendon, C. L., Lambert, J., Iwatsubo, T., & Mann, D. M. A. (2005) · Acta Neuropathologica · doi:10.1007/s00401-005-1108-3 · Cited by 23 · see citing works
Genetic Epidemiology of Alzheimer Disease
Mayeux, R. P. (2006) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200607001-00008 · Cited by 23 · see citing works
Expanded high-resolution genetic study of 109 Swedish families with Alzheimer's disease
Sillén, A., Andrade, J., Lilius, L., Forsell, C., Axelman, K., Odeberg, J., Winblad, B. G., & Graff, C. (2007) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201946 · Cited by 22 · see citing works
Association of tagSNPs in the urokinase‐plasminogen activator (PLAU) gene with Alzheimer's disease and associated quantitative traits
Öztürk, A., Minster, R. L., DeKosky, S. T., & Kamboh, M. I. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30403 · Cited by 22 · see citing works
Self-citation
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Hamson, D. K., Roes, M., & Galea, L. (2016) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2016.tb00710.x · Cited by 179 · see citing works
Beyond Transgenic Mice: Emerging Models and Translational Strategies in Alzheimer’s Disease
Lopes, P. A., & Guil‐Guerrero, J. L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125541 · Cited by 23 · see citing works
Induced Pluripotent Stem Cells Derived from Alzheimer’s Disease Patients: The Promise, the Hope and the Path Ahead
Freude, K., Pires, C., Hyttel, P., & Hall, V. J. (2014) · Journal of Clinical Medicine · doi:10.3390/jcm3041402 · Cited by 20 · see citing works
Genetic variation in the choline O-acetyltransferase gene in depression and Alzheimer’s disease: The VITA and Milano studies
Grünblatt, E., Reif, A., Jungwirth, S., Galimberti, D., Weber, H., Scarpini, E. A., Sauer, C., Wichart, I., Rainer, M. K., Huber, K. R., et al. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.03.017 · Cited by 19 · see citing works
No association of DAPK1 and ABCA2 SNPs on chromosome 9 with Alzheimer's disease
Minster, R. L., DeKosky, S. T., & Kamboh, M. I. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.01.006 · Cited by 19 · see citing works
Self-citation
Age, Alzheimer's disease, and the big picture
Ganguli, M., & Rodríguez, E. (2011) · International Psychogeriatrics · doi:10.1017/s1041610211001906 · Cited by 18 · see citing works
Emerging Medical Technologies and Emerging Conceptions of Health
S.J., W. E. S. (2006) · Metamedicine · doi:10.1007/s11017-006-9003-z · Cited by 18 · see citing works
Genetics of Late-Onset Alzheimer’s Disease: Progress and Prospect
Li, Y., & Grupe, A. (2007) · Pharmacogenomics · doi:10.2217/14622416.8.12.1747 · Cited by 18 · see citing works
Brain-Derived Neurotrophic Factor Gene Variants and Alzheimer Disease: An Association Study in an Alzheimer Disease Italian Population
Boiocchi, C., Maggioli, E., Zorzetto, M., Sinforiani, E., Cereda, C., Ricevuti, G., & Cuccia, M. (2012) · Rejuvenation Research · doi:10.1089/rej.2012.1381 · Cited by 17 · see citing works
Insights in the structural understanding of amyloidogenicity and mutation-led conformational dynamics of amyloid beta (Aβ) through molecular dynamics simulations and principal component analysis
Raghavan, S. S., Iqbal, S., Ayyadurai, N., & Gunasekaran, K. (2021) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2021.1871955 · Cited by 15 · see citing works
Polymorphic SERPINA3 prolongs oligomeric state of amyloid beta
Akbor, M. M., Kurosawa, N., Nakayama, H., Nakatani, A., Tomobe, K., Chiba, Y., Ueno, M., Tanaka, M., Nomura, Y., & Isobe, M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248027 · Cited by 17 · see citing works
The Genetics of Alzheimer’s Disease and Parkinson’s Disease
Bekris, L., Yu, C.-E., Bird, T., & Tsuang, D. (2011) · Advances in neurobiology · doi:10.1007/978-1-4419-7104-3_21 · Cited by 14 · see citing works
Association studies of 22 candidate SNPs with late‐onset Alzheimer's disease
Figgins, J. A., Minster, R. L., Demirci, F. Y., DeKosky, S. T., & Kamboh, M. I. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30851 · Cited by 15 · see citing works
Self-citation
Heme Deficiency in Alzheimer’s Disease: A Possible Connection toPorphyria
Dwyer, B. E., Stone, M. L., Zhu, X., Perry, G. L., & Smith, M. A. (2006) · BioMed Research International · doi:10.1155/jbb/2006/24038 · Cited by 16 · see citing works

Authors: Kamboh, M. I.
Affiliations: University of Pittsburgh (US)
Corresponding author: Kamboh, M. Ilyas
ORCID: Kamboh, M. Ilyas
Venue: Annals of Human Genetics
Publisher: Wiley
Published: 2004-06-28
Volume: 68
Issue: 4
Pages: 381-404
ISSN: 0003-4800 (ISSN-L)
1469-1809
DOI: 10.1046/j.1529-8817.2004.00110.x
OpenAlex: W2137932456
Cited by: 170
References: 131
Citations by year: 2025: 4 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 7 · 2013: 6 · 2012: 12
FWCI: 2.76
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Annals of Human Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG 05-133, P50AG005133, AG13672, R01AG013672)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: late-onset Alzheimer's disease, apolipoprotein E, genetic susceptibility, genetic loci, genome-wide linkage analysis, linkage disequilibrium, complex diseases, genetic risk factors
MeSH terms: Alzheimer Disease, Apolipoproteins E, Humans, Genetic Linkage, Molecular Biology, Biomarkers

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Molecular Genetics of Late‐Onset Alzheimer's Disease

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