Elevated expression of beta-site amyloid precursor protein cleaving enzyme 2 in brains of patients with Down syndrome
Abstract
The gene encoding the beta-site amyloid precursor protein cleaving enzyme 2 (BACE2) has been determined to be located on the long arm of chromosome 21 at 21q22.3. BACE2 cleaves the amyloid precursor protein at the beta-secretase site and is thought to contribute to amyloid beta protein production. In the present study, changes in the expression of BACE2 were investigated immunohistochemically in the frontal cortex of patients with Down syndrome (DS). The immunoreactivity for BACE2 was detected in neurofibrillary tangle-bearing neurons from the elderly DS brains with Alzheimer-type neuropathology, but were not detected in those of DS brains without Alzheimer-type neuropathology or of control brains of any age. This suggests the possibility that the elevated expression of BACE2 is involved in the Alzheimer-type neuropathology of DS.
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Immunocytochemical studies of brain tissue from DS subjects have shown a direct correlation between elevated BACE-2 in brain and AD-like neuropathology.
“Immunocytochemical studies of brain tissue from DS subjects have shown a direct correlation between the appearance of elevated levels of BACE-2 in brain and the presence of AD-like neuropathology (Motonaga et al., 2002).”
From <i>App</i>Gene Dosage Modulates Endosomal Abnormalities of Alzheimer's Disease in a Segmental Trisomy 16 Mouse Model of Down Syndrome (2003) · cites this paper as Motonaga et al., 2002
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- Authors
- Motonaga, K., Itoh, M., Becker, L. E., Goto, Y.-I., & Takashima, S.
- Affiliations
- National Center of Neurology and Psychiatry (JP)
- Hospital for Sick Children (CA)
- Corresponding author
- Motonaga, Kozo
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 326
- Issue
- 1
- Pages
- 64-66
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2014284997
- Cited by
- 45
- References
- 0
- Citations by year
- 2022: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- BACE2, Down syndrome, amyloid-beta, neurofibrillary tangles, frontal cortex, gene expression, chromosome 21, beta-secretase
- MeSH terms
- Adolescent, Adult, Age Factors, Alzheimer Disease, Autopsy, Child, Child, Preschool, Down Syndrome, Frontal Lobe, Humans, Immunohistochemistry, Infant, Middle Aged, Endopeptidases, Immunoblotting, Up-Regulation, Gene Expression Regulation, Enzymologic, Aspartic Acid Endopeptidases, Amyloid Precursor Protein Secretases
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