Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer’s disease

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

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Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

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Alzheimer's Disease: Genes, Proteins, and Therapy

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

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Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

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Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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Candidate gene for the chromosome 1 familial Alzheimer’s disease locus

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HUMAN PLASMA PROTEINASE INHIBITORS

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A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

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Amyloid β-peptide is produced by cultured cells during normal metabolism

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

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High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

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Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

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Purification and cloning of amyloid precursor protein β-secretase from human brain

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Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

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Oligomeric and fibrillar species of amyloid-β peptides differentially affect neuronal viability

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Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

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Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

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Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier

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A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

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Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

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Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

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Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline

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A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60

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Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons

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Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease

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LRP: a multifunctional scavenger and signaling receptor

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Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo

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Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

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Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing

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LRP: a multifunctional scavenger and signaling receptor

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Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

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Metabolic Regulation of Brain Aβ by Neprilysin

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Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

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Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

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Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition

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Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1

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Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics

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Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation

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A Familial Alzheimer's Disease Locus on Chromosome 1

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Skeletal and CNS Defects in Presenilin-1-Deficient Mice

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aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation

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Presenilin is required for activity and nuclear access of Notch in Drosophila

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Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10

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BACE1 is the major β-secretase for generation of Aβ peptides by neurons

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Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein

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Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides1Published on the World Wide Web on 17 August 1999.1

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Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm

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Structure of the Protease Domain of Memapsin 2 (β-Secretase) Complexed with Inhibitor

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The LDL–receptor–related protein, LRP, is an apolipoprotein E-binding protein

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CD91: a receptor for heat shock protein gp96

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Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor.

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Alpha-2 macroglobulin is genetically associated with Alzheimer disease

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Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP

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Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

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Clearing the brain's amyloid cobwebs

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Interaction of Cytosolic Adaptor Proteins with Neuronal Apolipoprotein E Receptors and the Amyloid Precursor Protein

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Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state

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Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

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Evidence for Genetic Linkage of Alzheimer's Disease to Chromosome 10q

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Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

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Regulation of APP cleavage by α‐, β‐ and γ‐secretases

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Neurons Regulate Extracellular Levels of Amyloid β-Protein via Proteolysis by Insulin-Degrading Enzyme

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LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation

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Alzheimer’s Presenilin Mutation Sensitizes Neural Cells to Apoptosis Induced by Trophic Factor Withdrawal and Amyloid β-Peptide: Involvement of Calcium and Oxyradicals

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Total inactivation of γ–secretase activity in presenilin-deficient embryonic stem cells

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