Abnormal expression of cdk5 in focal cortical dysplasia in humans.
Abstract
Focal cortical dysplasia (FCD) is an important cause of refractory epilepsy in humans. The origin of its pathognomonic abnormal cell types and the links between abnormal cell morphology and epileptogenicity remain unknown. The developmentally-regulated kinase cdk5 and its neuronal activator p35 are known to be central to a number of key components in neuronal development, cellular morphology, cytoskeletal function, synaptic plasticity and neurodegeneration. Here we examine eight cases of human FCD for expression of cdk5. We show abnormal cdk5 immunoreactivity and aggregation of protein suggesting alterations in cdk5 may also be involved in this important epileptogenic human pathology.
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Dysplastic cortical neurons in focal cortical dysplasia patients express CDK5 aggregations.
“and dysplastic cortical neurons in FCD patients express CDK5 aggregations (Sisodiya et al., 2002).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Sisodiya et al., 2002
Cites
Chen, J., Zhang, Y., Kelz, M. B., Steffen, C., Ang, E. S., Zeng, L., & Nestler, E. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-08965.2000 · Cited by 101 · see citing works
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Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms
Hwang, K., Vaknalli, R. N., Addo-Osafo, K., Vicente, M., & Vossel, K. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.903973 · Cited by 35 · see citing works
The potential role of cyclin-dependent kinase 5 in focal cortical dysplasia.
Sen, A., Thom, M., Nikolić, M., & Sisodiya, S. M. (2008) · Developmental Neuroscience · doi:10.1159/000109855 · Cited by 10 · see citing works
Self-citation
- Authors
- Sisodiya, S. M., Thom, M., Lin, W.-R., Bajaj, N. P. S., Cross, J. H., & Harding, B. N.
- Affiliations
- National Hospital for Neurology and Neurosurgery (GB)
- King's College London (GB)
- Great Ormond Street Hospital (GB)
- Corresponding author
- Sisodiya, Sanjay M
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 328
- Issue
- 3
- Pages
- 217-220
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1966222806
- Cited by
- 22
- References
- 1
- Citations by year
- 2022: 1 · 2014: 1 · 2013: 1
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Physiology › Tuberous Sclerosis Complex Research
- Keywords
- focal cortical dysplasia, cyclin-dependent kinase 5, p35, drug-resistant epilepsy, epileptogenicity, protein aggregation, neuronal development, cytoskeletal function, synaptic plasticity
- MeSH terms
- Congenital Abnormalities, Cerebral Cortex, Humans, Neurons, Cyclin-Dependent Kinases, Cyclin-Dependent Kinase 5
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