Induction of Cyclin-Dependent Kinase 5 in the Hippocampus by Chronic Electroconvulsive Seizures: Role of ΔFosB
Open accessAbstract
The transcription factor ΔFosB is induced in the hippocampus and other brain regions by repeated electroconvulsive seizures (ECS), an effective antidepressant treatment. The unusually high stability of this protein makes it an attractive candidate to mediate some of the long-lasting changes in the brain caused by ECS treatment. To understand how ΔFosB might alter brain function, we examined the gene expression profiles in the hippocampus of inducible transgenic mice that express ΔFosB in this brain region by the use of cDNA expression arrays that contain 588 genes. Of the 430 genes detected, 20 genes were consistently upregulated, and 14 genes were downregulated, by >50%. One of the upregulated genes is cyclin-dependent kinase 5 (cdk5). On the basis of its purported role in regulating neuronal structure, we studied directly whether cdk5 is a true target for ΔFosB. Upregulation of cdk5 immunoreactivity in the hippocampus was confirmed by Western blotting in the ΔFosB-expressing transgenic mice as well as in rats treated chronically with ECS. Chronic ECS treatment also increased, in the hippocampus, the phosphorylation state of tau, a microtubule-associated protein that is a known substrate for cdk5. A 1.6 kb fragment of the cdk5 promoter was cloned, and activity of the promoter was found to be increased after overexpression of ΔFosB in cell culture. Moreover, mutation of the single consensus activator protein-1 site contained within the cdk5 promoter fragment completely abolished activation of the promoter by ΔFosB. Together, these results suggest that cdk5 is one target by which ΔFosB produces some of its physiological effects in the hippocampus and thereby mediates certain long-term consequences of chronic ECS treatment.
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Progressive activation of CDK5 co-occurs with increasing tau phosphorylation in rodent seizure models.
“Furthermore, progressive activation of CDK5 co-occurs with increasing tau phosphorylation in rodent seizure models (Chen et al., 2000; Liang et al., 2009), indicating significant mediation of seizure-associated tau hyperphosphorylation by CDK5.”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Chen et al., 2000
The Results section (‘Evidence of increased cdk5 catalytic activity after chronic ECS treatment’; page not available) reports increased phosphorylated tau and the CDK5 activator p25 in rat hippocampus after chronic seizures. The Discussion says these findings are consistent with increased CDK5 catalytic activity, but the paper does not show a progressive rise in either measure over time or directly measure CDK5 catalytic activity. (LLM, conf=0.86)
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- Authors
- Chen, J., Zhang, Y., Kelz, M. B., Steffen, C., Ang, E. S., Zeng, L., & Nestler, E. J.
- Affiliations
- Yale University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2000-12-15
- Volume
- 20
- Issue
- 24
- Pages
- 8965-8971
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W4322703188
- Cited by
- 101
- References
- 38
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 4 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Funders
- National Institute of Mental Health
- National Institute on Drug Abuse
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- ΔFosB, cyclin-dependent kinase 5, electroconvulsive seizures, hippocampus, gene expression profiling, AP-1 transcription factor, tau phosphorylation, transgenic mice, antidepressant treatment, long-term synaptic plasticity
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