Mutation screening of the human period 2 gene in bipolar disorder
Abstract
We tested whether the human period 2 gene (hper2), one of the essential components of the circadian oscillator, might have influence on bipolar disorder. We screened 88 bipolar disorder patients and 127 controls, all of Japanese origin. Screening in the casein kinase I epsilon (CKIepsilon) binding region of hper2, which was previously reported in familial advanced sleep-phase syndrome patients, with polymerase chain reaction amplification revealed four polymorphisms. One of the four polymorphisms had an amino acid substitution of a serine at 662 with a glycine (S662G). The frequencies of the S662G allele and genotypes on patients with bipolar disorder were very low and had no difference from those in controls. Polymorphism on the CKIepsilon binding region of hper2 gene which was previously reported, is unlikely to play an important role in the development of bipolar disorder.
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Other studies that examined SNPs throughout the sequence of some central members of the circadian clock have found no associations with these genes and any psychiatric disorders.
“other studies that have examined SNPs throughout the sequence of some of the central members of the circadian clock have found no associations with these genes and any psychiatric disorders (Shiino et al., 2003; Nievergelt et al., 2005; Mansour et al., 2006; Nievergelt et al., 2006).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Shiino et al., 2003
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Circadian genes, rhythms and the biology of mood disorders
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- Authors
- Shiino, Y., Nakajima, S., Ozeki, Y., Isono, T., & Yamada, N.
- Affiliations
- Shiga University of Medical Science (JP)
- Corresponding author
- Yamada, Naoto
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 338
- Issue
- 1
- Pages
- 82-84
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2121503525
- Cited by
- 30
- References
- 19
- Citations by year
- 2020: 1 · 2018: 2 · 2017: 1 · 2014: 1 · 2012: 2
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- bipolar disorder, circadian clock, genetic polymorphism, advanced sleep phase syndrome, Japanese patients
- MeSH terms
- Adolescent, Adult, Aged, Alleles, Binding Sites, Bipolar Disorder, DNA Mutational Analysis, Female, Genetic Testing, Humans, Male, Middle Aged, Nuclear Proteins, Polymorphism, Genetic, Protein Kinases, Proteins, Transcription Factors, Casein Kinases, Period Circadian Proteins
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