An h Per2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome

A comprehensive genetic map of the human genome based on 5,264 microsatellites

Dib, C., Fauré, S., Fizames, C., Samson, D. S., Drouot, N., Alain Vignal, A., Millasseau, P., Marc, S., Kazan, J., Seboun, E., et al. (1996) · Nature · doi:10.1038/380152a0 · Cited by 2,927 · see citing works

Molecular Bases for Circadian Clocks

Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900 · see citing works

Clock Mutants of Drosophila melanogaster

Konopka, R. J., & Benzer, S. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.9.2112 · Cited by 2,287 · see citing works

Interacting molecular loops in the mammalian circadian clock

Shearman, L. P., Sriram, S., Weaver, D. R., Maywood, E. S., Chaves, I., Zheng, B., Kume, K., Lee, C. C., van der, G. T. J., Horst, et al. (2000) · Science · doi:10.1126/science.288.5468.1013 · Cited by 1,367 · see citing works

A Differential Response of Two Putative Mammalian Circadian Regulators, mper1and mper2, to Light

Albrecht, U., Sun, Z. S., Eichele, G., & Lee, C. C. (1997) · Cell · doi:10.1016/s0092-8674(00)80495-x · Cited by 879 · see citing works

Three period Homologs in Mammals: Differential Light Responses in the Suprachiasmatic Circadian Clock and Oscillating Transcripts Outside of Brain

Zylka, M. J., Shearman, L. P., Weaver, D. R., & Reppert, S. M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80492-4 · Cited by 865 · see citing works

Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau

Lowrey, P. L., Shimomura, K., Antoch, M. P., Yamazaki, S., Zemenides, P. D., Ralph, M. R., Menaker, M., & Takahashi, J. S. (2000) · Science · doi:10.1126/science.288.5465.483 · Cited by 860 · see citing works

double-time Is a Novel Drosophila Clock Gene that Regulates PERIOD Protein Accumulation

Price, J. L., Blau, J., Rothenfluh, A., Abodeely, M., Kloss, B., & Young, M. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81224-6 · Cited by 839 · see citing works

The mPer2 gene encodes a functional component of the mammalian circadian clock

Zheng, B., Larkin, D. W., Albrecht, U., Sun, Z. S., Sage, M., Eichele, G., Lee, C. C., & Bradley, A. (1999) · Nature · doi:10.1038/22118 · Cited by 718 · see citing works

The Drosophila Clock Gene double-time Encodes a Protein Closely Related to Human Casein Kinase Iε

Kloss, B., Price, J. L., Sáez, L., Blau, J., Rothenfluh, A., Wesley, C. S., & Young, M. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81225-8 · Cited by 682 · see citing works

Familial advanced sleep-phase syndrome: a short-period circadian rhythm variant in humans

Jones, C. R., Campbell, S. S., Zone, S. E., Cooper, F., DeSano, A., Murphy, P. J., Jones, B., Czajkowski, L., & Ptček, L. J. (1999) · Nature Medicine · doi:10.1038/12502 · Cited by 567 · see citing works

Molecular Genetics of Circadian Rhythms in Mammals

King, D. P., & Takahashi, J. S. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.713 · Cited by 551 · see citing works

The Suprachiasmatic Nucleus: A 25-Year Retrospective

Weaver, D. R. (1998) · Journal of Biological Rhythms · doi:10.1177/074873098128999952 · Cited by 508 · see citing works

Dihydropyridine receptor mutations cause hypokalemic periodic paralysis

Ptáček, L. J. (1994) · Cell · doi:10.1016/0092-8674(94)90135-x · Cited by 426 · see citing works

Phosphate groups as substrate determinants for casein kinase I action.

Flotow, H., Graves, P. R., Wang, A. Q., Fiol, C. J., Roeske, R. W., & Roach, P. J. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77295-5 · Cited by 337 · see citing works

Nuclear Entry of the Circadian Regulator mPER1 Is Controlled by Mammalian Casein Kinase I ɛ

Vielhaber, E. L., Eide, E. J., Rivers, A. M., Gao, Z.-H., & Virshup, D. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4888-4899.2000 · Cited by 308 · see citing works

Damage-mediated Phosphorylation of Human p53 Threonine 18 through a Cascade Mediated by a Casein 1-like Kinase

Sakaguchi, K., Saito, S., Higashimoto, Y., Roy, S., Anderson, C. W., & Appella, E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.13.9278 · Cited by 293 · see citing works

Circadian rhythm genetics: from flies to mice to humans

Wager‐Smith, K., & Kay, S. A. (2000) · Nature Genetics · doi:10.1038/79134 · Cited by 232 · see citing works

A Clockwork Explosion!

Reppert, S. M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80234-2 · Cited by 179 · see citing works

Behavior of period-altered circadian rhythm mutants ofDrosophila in light: Dark cycles (Diptera: Drosophilidae)

Hamblen, M. J., Wheeler, D. A., Rutila, J. E., Rosbash, M., & Hall, J. C. (1992) · Journal of Insect Behavior · doi:10.1007/bf01058189 · Cited by 167 · see citing works

Protein kinase CK1 is a p53‐threonine 18 kinase which requires prior phosphorylation of serine 15

Dumaz, N., Milne, D., & Meek, D. W. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01647-6 · Cited by 142 · see citing works

Phosphorylation and destabilization of human period I clock protein by human casein kinase Iε

Keesler, G. A., Camacho, F., Guo, Y. X., Virshup, D. M., Mondadori, C., & Yao, Z. (2000) · Neuroreport · doi:10.1097/00001756-200004070-00011 · Cited by 136 · see citing works

T-antigen kinase inhibits simian virus 40 DNA replication by phosphorylation of intact T antigen on serines 120 and 123

Cegielska, A., Moarefi, I., Fanning, E., & Virshup, D. M. (1994) · Journal of Virology · doi:10.1128/jvi.68.1.269-275.1994 · Cited by 76 · see citing works

Isadora

Duffy, K. (1999) · Comhar · doi:10.2307/25573912 · Cited by 1 · see citing works

Coordination of circadian timing in mammals

Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379 · see citing works

Life between Clocks: Daily Temporal Patterns of Human Chronotypes

Roenneberg, T., Wirz-Justice, A., & Merrow, M. (2003) · Journal of Biological Rhythms · doi:10.1177/0748730402239679 · Cited by 2,662 · see citing works

Transcriptional architecture of the mammalian circadian clock

Takahashi, J. S. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.150 · Cited by 2,637 · see citing works

Pathophysiology of migraine: a disorder of sensory processing

Goadsby, P. J., Holland, P. R., Martins-Oliveira, M., Hoffmann, J., Schankin, C., & Akerman, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00034.2015 · Cited by 1,998 · see citing works

Molecular components of the mammalian circadian clock

Ko, C. H., & Takahashi, J. S. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl207 · Cited by 1,657 · see citing works

The genetics of mammalian circadian order and disorder: implications for physiology and disease

Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611 · see citing works

A marker for the end of adolescence

Roenneberg, T., Kuehnle, T., Pramstaller, P. P., Ricken, J., Havel, M., Guth, A., & Merrow, M. (2004) · Current Biology · doi:10.1016/j.cub.2004.11.039 · Cited by 1,585 · see citing works

Epidemiology of the human circadian clock

Roenneberg, T., Kuehnle, T., Juda, M., Kantermann, T., Allebrandt, K., Gordijn, M., & Merrow, M. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.07.005 · Cited by 1,545 · see citing works

Control of sleep and wakefulness

Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477 · see citing works

Molecular architecture of the mammalian circadian clock

Partch, C. L., Green, C. B., & Takahashi, J. S. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.07.002 · Cited by 1,449 · see citing works

A copy number variation morbidity map of developmental delay

Cooper, G. M., Coe, B. P., Girirajan, S., Rosenfeld, J. A., Vu, T. H., Baker, C., Williams, C., Stalker, H., Hamid, R., Hannig, V., et al. (2011) · Nature Genetics · doi:10.1038/ng.909 · Cited by 1,351 · see citing works

Circadian typology: a comprehensive review

Adan, A., Archer, S. N., Hidalgo, M. P., Di Milia, L., Natale, V., & Randler, C. (2012) · Chronobiology International · doi:10.3109/07420528.2012.719971 · Cited by 1,384 · see citing works

Molecular mechanisms and physiological importance of circadian rhythms

Patke, A., Young, M. W., & Axelrod, S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0179-2 · Cited by 1,388 · see citing works

The Circadian Gene Period2 Plays an Important Role in Tumor Suppression and DNA Damage Response In Vivo

Fu, L., Pelicano, H., Liu, J., Huang, P., & Lee, C. C. (2002) · Cell · doi:10.1016/s0092-8674(02)00961-3 · Cited by 1,256 · see citing works

A clockwork web: circadian timing in brain and periphery, in health and disease

Hastings, M. H., Reddy, A. B., & Maywood, E. S. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1177 · Cited by 1,189 · see citing works

Posttranslational Mechanisms Regulate the Mammalian Circadian Clock

Lee, C., Etchegaray, J., Cagampang, F. R. A., Loudon, A. S. I., & Reppert, S. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00610-9 · Cited by 1,158 · see citing works

Time zones: a comparative genetics of circadian clocks

Young, M. W., & Kay, S. A. (2001) · Nature Reviews Genetics · doi:10.1038/35088576 · Cited by 1,143 · see citing works

Circadian physiology of metabolism

Panda, S. (2016) · Science · doi:10.1126/science.aah4967 · Cited by 1,092 · see citing works

Discovering Endophenotypes for Major Depression

Hasler, G., Drevets, W. C., Manji, H. K., & Charney, D. S. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300506 · Cited by 1,123 · see citing works

Physiology of Circadian Entrainment

Golombek, D. A., & Rosenstein, R. E. (2010) · Physiological Reviews · doi:10.1152/physrev.00009.2009 · Cited by 1,103 · see citing works

Circadian rhythms from flies to human

Panda, S., Hogenesch, J. B., & Kay, S. A. (2002) · Nature · doi:10.1038/417329a · Cited by 1,044 · see citing works

Neural Circuitry of Wakefulness and Sleep

Scammell, T. E., Arrigoni, E., & Lipton, J. O. (2017) · Neuron · doi:10.1016/j.neuron.2017.01.014 · Cited by 966 · see citing works

Mammalian circadian biology: elucidating genome-wide levels of temporal organization

Lowrey, P. L., & Takahashi, J. S. (2004) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.5.061903.175925 · Cited by 976 · see citing works

Mechanisms linking circadian clocks, sleep, and neurodegeneration

Musiek, E. S., & Holtzman, D. M. (2016) · Science · doi:10.1126/science.aah4968 · Cited by 878 · see citing works

Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock

Bae, K., Jin, X., Maywood, E. S., Hastings, M. H., Reppert, S. M., & Weaver, D. R. (2001) · Neuron · doi:10.1016/s0896-6273(01)00302-6 · Cited by 900 · see citing works

Post-translational modifications regulate the ticking of the circadian clock

Gallego, M., & Virshup, D. M. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2106 · Cited by 863 · see citing works

Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome

Xu, Y., Padiath, Q. S., Shapiro, R. E., Jones, C. R., Wu, S. C., Saigoh, N., Saigoh, K., Ptáček, L. J., & Fu, Y.-H. (2005) · Nature · doi:10.1038/nature03453 · Cited by 861 · see citing works

Molecular components of the mammalian circadian clock

Buhr, E. D., & Takahashi, J. S. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25950-0_1 · Cited by 738 · see citing works

A Length Polymorphism in the Circadian Clock Gene Per3 is Linked to Delayed Sleep Phase Syndrome and Extreme Diurnal Preference

Archer, S. N., Robilliard, D. L., Skene, D. J., Smits, M. G., Williams, A., Arendt, J., & von Schantz, M. (2003) · SLEEP · doi:10.1093/sleep/26.4.413 · Cited by 734 · see citing works

Circadian rhythms, sleep, and metabolism

Huang, W., Ramsey, K. M., Marcheva, B., & Bass, J. T. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46043 · Cited by 726 · see citing works

Mechanisms and function of substrate recruitment by F-box proteins

Skaar, J. R., Pagan, J. K., & Pagano, M. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3582 · Cited by 671 · see citing works

The circadian clock: pacemaker and tumour suppressor

Fu, L., & Lee, C. C. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1072 · Cited by 678 · see citing works

Association between circadian rhythms and neurodegenerative diseases

Leng, Y., Musiek, E. S., Hu, K., Cappuccio, F. P., & Yaffe, K. S. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30461-7 · Cited by 660 · see citing works

Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

Dashti, H. S., Jones, S. E., Wood, A. R., Lane, J. M., van Hees, V. T., Wang, H., Rhodes, J. A., Song, Y., Patel, K., Anderson, S. G., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08917-4 · Cited by 595 · see citing works

The casein kinase 1 family: participation in multiple cellular processes in eukaryotes

Knippschild, U., Gocht, A., Wolff, S., Huber, N., Löhler, J., & Stöter, M. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2004.12.011 · Cited by 601 · see citing works

Computational approaches to cellular rhythms

Goldbeter, A. (2002) · Nature · doi:10.1038/nature01259 · Cited by 581 · see citing works

Toward a detailed computational model for the mammalian circadian clock

Leloup, J., & Goldbeter, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1132112100 · Cited by 535 · see citing works

Circadian Mechanisms in Medicine

Allada, R., & Bass, J. (2021) · New England Journal of Medicine · doi:10.1056/nejmra1802337 · Cited by 519 · see citing works

Genomics of circadian rhythms in health and disease

Rijo‐Ferreira, F., & Takahashi, J. S. (2019) · Genome Medicine · doi:10.1186/s13073-019-0704-0 · Cited by 537 · see citing works

Circadian Rhythm Sleep Disorders: Part II, Advanced Sleep Phase Disorder, Delayed Sleep Phase Disorder, Free-Running Disorder, and Irregular Sleep-Wake Rhythm

Sack, R. L., Auckley, D. H., Auger, R. R., Carskadon, M. A., Wright, K. P., Vitiello, M. V., & Zhdanova, I. V. (2007) · SLEEP · doi:10.1093/sleep/30.11.1484 · Cited by 530 · see citing works

PER3 polymorphism predicts sleep structure and waking performance

Viola, A. U., Archer, S. N., James, L. M., Groeger, J. A., Lo, J. C. Y., Skene, D. J., von Schantz, M., & Dijk, D.-J. (2007) · Current Biology · doi:10.1016/j.cub.2007.01.073 · Cited by 520 · see citing works

Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation

Miller, B. H., McDearmon, E. L., Panda, S., Hayes, K. R., Zhang, J., Andrews, J. L., Antoch, M. P., Walker, J. R., Esser, K. A., Hogenesch, J. B., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611724104 · Cited by 509 · see citing works

Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome

Ebisawa, T., Uchiyama, M., Kajimura, N., Mishima, K., Kamei, Y., Katoh, M., Watanabe, T., Sekimoto, M., Shibui, K., Kim, K., et al. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve070 · Cited by 517 · see citing works

Short Linear Motifs: Ubiquitous and Functionally Diverse Protein Interaction Modules Directing Cell Regulation

Roey, K. V., Uyar, B., Weatheritt, R. J., Dinkel, H., Seiler, M., Budd, A., Gibson, T. J., & Davey, N. E. (2014) · Chemical Reviews · doi:10.1021/cr400585q · Cited by 496 · see citing works

Control of Mammalian Circadian Rhythm by CKIε-Regulated Proteasome-Mediated PER2 Degradation

Eide, E. J., Woolf, M. F., Kang, H., Woolf, P., Hurst, W., Camacho, F., Vielhaber, E. L., Giovanni, A., & Virshup, D. M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.7.2795-2807.2005 · Cited by 495 · see citing works

Glucocorticoid hormones inhibit food‐induced phase‐shifting of peripheral circadian oscillators

Minh, N. L., Damiola, F., Tronche, F., Schütz, G., & Schibler, U. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.7128 · Cited by 467 · see citing works

Drosophila: Genetics meets behaviour

Sokolowski, M. B. (2001) · Nature Reviews Genetics · doi:10.1038/35098592 · Cited by 474 · see citing works

Evidence‐Based Recommendations for the Assessment and Management of Sleep Disorders in Older Persons

Bloom, H. G., Ahmed, I., Alessi, C. A., Ancoli‐Israel, S., Buysse, D. J., Kryger, M. H., Phillips, B. A., Thorpy, M. J., Vitiello, M. V., & Zee, P. C. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02220.x · Cited by 464 · see citing works

Circadian Organization of Behavior and Physiology in Drosophila

Allada, R., & Chung, B. Y. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135815 · Cited by 456 · see citing works

Molecular Bases of Circadian Rhythms

Harmer, S. L., Panda, S., & Kay, S. A. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.215 · Cited by 440 · see citing works

Sleep and circadian rhythm disruption in schizophrenia

Wulff, K., Dijk, D.-J., Middleton, B., Foster, R. G., & Joyce, E. M. (2012) · British Journal of Psychiatry · doi:10.1192/bjp.bp.111.096321 · Cited by 426 · see citing works

Toward constructing an endophenotype strategy for bipolar disorders

Hasler, G., Drevets, W. C., Gould, T. D., Gottesman, I. I., & Manji, H. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.006 · Cited by 423 · see citing works

Circadian clocks: regulators of endocrine and metabolic rhythms

Hastings, M., O’Neill, J. S., & Maywood, E. S. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0378 · Cited by 426 · see citing works

Circadian Rhythms and Sleep in Drosophila melanogaster

Dubowy, C., & Sehgal, A. (2017) · Genetics · doi:10.1534/genetics.115.185157 · Cited by 421 · see citing works

Genetics of Sleep and Sleep Disorders

Sehgal, A., & Mignot, E. J.-M. (2011) · Cell · doi:10.1016/j.cell.2011.07.004 · Cited by 407 · see citing works

Human Responses to the Geophysical Daily, Annual and Lunar Cycles

Foster, R. G., & Roenneberg, T. (2008) · Current Biology · doi:10.1016/j.cub.2008.07.003 · Cited by 410 · see citing works

Clocks not winding down: unravelling circadian networks

Zhang, E. E., & Kay, S. A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2995 · Cited by 446 · see citing works

Modeling of a Human Circadian Mutation Yields Insights into Clock Regulation by PER2

Xu, Y., Toh, K. L., Jones, C. R., Shin, J., Fu, Y., & Ptáček, L. J. (2007) · Cell · doi:10.1016/j.cell.2006.11.043 · Cited by 405 · see citing works

Metabolism and the Control of Circadian Rhythms

Rutter, J. P., Reick, M., & McKnight, S. L. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.090501.142857 · Cited by 401 · see citing works

Circadian rhythms, sleep deprivation, and human performance

Goel, N., Basner, M., Rao, H., & Dinges, D. F. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00007-5 · Cited by 400 · see citing works

Invited Review: Integration of human sleep-wake regulation and circadian rhythmicity

Dijk, D., & Lockley, S. W. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00924.2001 · Cited by 394 · see citing works

The art of entrainment

Roenneberg, T., Daan, S., & Merrow, M. (2003) · Journal of Biological Rhythms · doi:10.1177/0748730403018003001 · Cited by 387 · see citing works

The genetic and molecular regulation of sleep: from fruit flies to humans

Cirelli, C. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2683 · Cited by 382 · see citing works

Do Corticosteroids Damage the Brain?

Herbert, J., Goodyer, I. M., Grossman, A. B., Hastings, M. H., de Kloet, E. R., Lightman, S. L., LUPIEN, S. J., Roozendaal, B., & Seckl, J. R. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01429.x · Cited by 384 · see citing works

Entrainment of Circadian Programs

Johnson, C. H., Elliott, J. A., & Foster, F. (2003) · Chronobiology International · doi:10.1081/cbi-120024211 · Cited by 380 · see citing works

Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS)Preprint

Vanselow, K., Vanselow, J. T., Westermark, P. O., Reischl, S., Maier, B., Korte, T., Herrmann, A., Herzel, H., Schlösser, A., & Kramer, A. (2006) · Genes & Development · doi:10.1101/gad.397006 · Cited by 383 · see citing works

The mammalian circadian timing system: from gene expression to physiology

Gachon, F., Nagoshi, E., Brown, S., Ripperger, J. A., & Schibler, U. (2004) · Chromosoma · doi:10.1007/s00412-004-0296-2 · Cited by 382 · see citing works

Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder

Patke, A., Murphy, P. J., Onat, O. E., Krieger, A. C., Özçelik, T., Campbell, S. S., & Young, M. W. (2017) · Cell · doi:10.1016/j.cell.2017.03.027 · Cited by 381 · see citing works

The epidemiology of morningness/eveningness: influence of age, gender, ethnicity, and socioeconomic factors in adults (30-49 years)

Paine, S.-J., Gander, P. H., & Travier, N. (2006) · Journal of Biological Rhythms · doi:10.1177/0748730405283154 · Cited by 377 · see citing works

Setting Clock Speed in Mammals: The CK1ɛ tau Mutation in Mice Accelerates Circadian Pacemakers by Selectively Destabilizing PERIOD Proteins

Meng, Q., Logunova, L., Maywood, E. S., Gallego, M., Lebiecki, J., Brown, T. M., Sládek, M., Semikhodskii, A. G., Glossop, N. R. J., Piggins, H. D., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.019 · Cited by 372 · see citing works

The Human Circadian Clock's Seasonal Adjustment Is Disrupted by Daylight Saving Time

Kantermann, T., Juda, M., Merrow, M. W., & Roenneberg, T. (2007) · Current Biology · doi:10.1016/j.cub.2007.10.025 · Cited by 357 · see citing works

Circadian rhythms and disorders of the timing of sleep

Meyer, N., Harvey, A. G., Lockley, S. W., & Dijk, D.-J. (2022) · The Lancet · doi:10.1016/s0140-6736(22)00877-7 · Cited by 346 · see citing works

Differential Association of Circadian Genes with Mood Disorders: CRY1 and NPAS2 are Associated with Unipolar Major Depression and CLOCK and VIP with Bipolar Disorder

Soria, V., Martínez‐Amorós, È., Escaramís, G., Valero, J., Pérez‐Egea, R., García, C. B., Gutiérrez‐Zotes, A., Puigdemont, D., Bayés, M., Crespo, J. M., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.230 · Cited by 352 · see citing works

The Transcriptional Repressor DEC2 Regulates Sleep Length in Mammals

He, Y., Jones, C. R., Fujiki, N., Xu, Y., Guo, B., Holder, J. L., Rossner, M. J., Nishino, S., & Fu, Y. (2009) · Science · doi:10.1126/science.1174443 · Cited by 346 · see citing works

A Drosophila model for age-associated changes in sleep:wake cycles

Koh, K., Evans, J. M., Hendricks, J. C., & Sehgal, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605903103 · Cited by 341 · see citing works

Individual Differences in Adult Human Sleep and Wakefulness: Leitmotif for a Research Agenda

Dongen, H. P. A. V., Vitellaro, K. M., & Dinges, D. F. (2005) · SLEEP · doi:10.1093/sleep/28.4.479 · Cited by 339 · see citing works

A role for casein kinase 2α in the Drosophila circadian clock

Lin, J.-M., Kilman, V. L., Keegan, K. P., Paddock, B. E., Emery-Le, M., Rosbash, M., & Allada, R. (2002) · Nature · doi:10.1038/nature01235 · Cited by 340 · see citing works

Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference

Johansson, C., Willeit, M., Smedh, C., Ekholm, J., Paunio, T., Kieseppä, T., Lichtermann, D., Praschak-Rieder, N., Neumeister, A., Nilsson, L.-G., et al. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300121 · Cited by 341 · see citing works

SCF ubiquitin ligase-targeted therapies

Skaar, J. R., Pagan, J. K., & Pagano, M. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4432 · Cited by 336 · see citing works

Insights from studying human sleep disorders

Mahowald, M. W., & Schenck, C. H. (2005) · Nature · doi:10.1038/nature04287 · Cited by 330 · see citing works

Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime

Ko, H. W., Jiang, J., & Edery, I. (2002) · Nature · doi:10.1038/nature01272 · Cited by 328 · see citing works

Dim Light at Night Disrupts Molecular Circadian Rhythms and Increases Body Weight

Fonken, L. K., Aubrecht, T. G., Meléndez‐Fernández, O. H., Weil, Z. M., & Nelson, R. J. (2013) · Journal of Biological Rhythms · doi:10.1177/0748730413493862 · Cited by 325 · see citing works

GWAS of 89,283 individuals identifies genetic variants associated with self-reporting of being a morning person

Hu, Y., Shmygelska, A., Tran, D., Eriksson, N., Tung, J. Y., & Hinds, D. A. (2016) · Nature Communications · doi:10.1038/ncomms10448 · Cited by 321 · see citing works

Neurons and networks in daily rhythms

Herzog, E. D. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2215 · Cited by 316 · see citing works

The Period Length of Fibroblast Circadian Gene Expression Varies Widely among Human Individuals

Brown, S. A., Fleury-Olela, F., Nagoshi, E., Hauser, C., Juge-Aubry, C. E., Meier, C. A., Chicheportiche, R., Dayer, J., Albrecht, U., & Schibler, U. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030338 · Cited by 315 · see citing works

Genetics on the Fly: A Primer on the Drosophila Model System

Hales, K. G., Korey, C. A., Larracuente, A. M., & Roberts, D. M. (2015) · Genetics · doi:10.1534/genetics.115.183392 · Cited by 316 · see citing works

Transcriptional oscillation of canonical clock genes in mouse peripheral tissues

Yamamoto, T., Nakahata, Y., Soma, H., Akashi, M., Mamine, T., & Takumi, T. (2004) · BMC Molecular Biology · doi:10.1186/1471-2199-5-18 · Cited by 308 · see citing works

The Circadian Regulatory Proteins BMAL1 and Cryptochromes Are Substrates of Casein Kinase Iε

Eide, E. J., Vielhaber, E. L., Hinz, W. A., & Virshup, D. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111466200 · Cited by 301 · see citing works

Control of Intracellular Dynamics of Mammalian Period Proteins by Casein Kinase I ε (CKIε) and CKIδ in Cultured Cells

Akashi, M., Tsuchiya, Y., Yoshino, T., & Nishida, E. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.6.1693-1703.2002 · Cited by 292 · see citing works

Suggestive evidence for association of the circadian genes <i>PERIOD3</i> and <i>ARNTL</i> with bipolar disorder

Nievergelt, C. M., Kripke, D. F., Barrett, T. B., Burg, E., Remick, R. A., Sadovnick, A. D., McElroy, S. L., Keck, P. E., Schork, N. J., & Kelsoe, J. R. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30252 · Cited by 294 · see citing works

Association study of eight circadian genes with bipolar I disorder, schizoaffective disorder and schizophrenia

Mansour, H. A., Wood, J., Logue, T., Chowdari, K. V., Dayal, M., Kupfer, D. J., Monk, T. H., Devlin, B., & Nimgaonkar, V. L. (2006) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2005.00147.x · Cited by 293 · see citing works

SCFβ-TRCP Controls Clock-dependent Transcription via Casein Kinase 1-dependent Degradation of the Mammalian Period-1 (Per1) Proteinm

Shirogane, T., Jin, J., Cambronne, X. A., & Harper, J. W. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502862200 · Cited by 293 · see citing works

Molecular Circadian Rhythms in Central and Peripheral Clocks in Mammals

Dardente, H., Dardente, H., & Cermakian, N. (2007) · Chronobiology International · doi:10.1080/07420520701283693 · Cited by 284 · see citing works

A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3β

Hirota, T., Lewis, W. G., Liu, A. C., Lee, J. W., Schultz, P. G., & Kay, S. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811410106 · Cited by 283 · see citing works

Unearthing the phylogenetic roots of sleep

Allada, R., & Siegel, J. M. (2008) · Current Biology · doi:10.1016/j.cub.2008.06.033 · Cited by 280 · see citing works

Circadian molecular clocks and cancer

Kelleher, F. C., Rao, A. D., & Maguire, A. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.09.040 · Cited by 276 · see citing works

FBXL21 Regulates Oscillation of the Circadian Clock through Ubiquitination and Stabilization of Cryptochromes

Hirano, A., Yumimoto, K., Tsunematsu, R., Matsumoto, M., Oyama, M., Kozuka‐Hata, H., Nakagawa, T., Lanjakornsiripan, D., Nakayama, K. I., & Fukada, Y. (2013) · Cell · doi:10.1016/j.cell.2013.01.054 · Cited by 274 · see citing works

The Orphan Nuclear Receptor Rev-erbα Recruits the N-CoR/Histone Deacetylase 3 Corepressor to Regulate the Circadian Bmal1 Gene

Yin, L., & Lazar, M. A. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0057 · Cited by 274 · see citing works

Robustness properties of circadian clock architectures

Stelling, J., Gilles, E. D., & Doyle, F. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401463101 · Cited by 273 · see citing works

Entrainment of the Human Circadian Clock

Roenneberg, T., & Merrow, M. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.043 · Cited by 272 · see citing works

An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science 291:1040–1043

Toh, K. L., Jones, C. R., He, Y., Eide, E. J., Hinz, W. A., Virshup, D. M., Ptáček, L. J., & Fu, Y. (2001)

Touching base

(2001) · Nature Genetics · doi:10.1038/84746

Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome

Xu, Y., Padiath, Q. S., Shapiro, R. E., Jones, C. R., Wu, S. C., Saigoh, N., Saigoh, K., Ptáček, L. J., & Fu, Y.-H. (2005) · Nature · doi:10.1038/nature03453 · Cited by 861 · see citing works

First human ‘clock’ gene

Dell, H. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(01)02253-3

A Family of Larks

(2001) · Science s STKE · doi:10.1126/stke.2001.69.tw7