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Human neprilysin is capable of degrading amyloid β peptide not only in the monomeric form but also the pathological oligomeric form
Open accessAbstract
Amyloid beta-peptide (Abeta) is widely believed to play a central role in Alzheimer's disease (AD). Coordinate regulation of cerebral Abeta level is important in the pathogenesis of AD since either increased production of Abeta from amyloid precursor protein or decreased degradation causes elevated levels of Abeta, leading to accumulation of cerebral plaque formation or amyloid angiopathy. Here we studied neprilysin, a putative proteolytic enzyme for Abeta, and found that it degraded not only monomeric but also oligomeric forms of Abeta1-40. Moreover, neprilysin was found to be capable of degradation of the oligomeric form of Abeta1-42, a significant Abeta species in early pathogenesis. Neprilysin to decrease cerebral Abeta is suggested to be inevitable factor as a vital therapeutic target.
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Oligomeric and fibrillar species of amyloid-β peptides differentially affect neuronal viability
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Overexpression of Insulin Degrading Enzyme: Cellular Localization and Effects on Insulin Signaling
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Cited by
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569
Traumatic brain injury and amyloid-β pathology: a link to Alzheimer's disease?
Johnson, V. E., Stewart, W., & Smith, D. H. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2808 · Cited by 587
Antiamyloidogenic and Neuroprotective Functions of Cathepsin B: Implications for Alzheimer's Disease
Mueller-Steiner, S., Zhou, Y., Arai, H., Roberson, E. D., Sun, B., Chen, J., Wang, X., Yu, G., Esposito, L., Mucke, L., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.027 · Cited by 465
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A new amyloid β variant favoring oligomerization in Alzheimer's‐type dementia
Tomiyama, T., Nagata, T., Shimada, H., Teraoka, R., Fukushima, A., Kanemitsu, H., Takuma, H., Kuwano, R., Imagawa, M., Ataka, S., et al. (2008) · Annals of Neurology · doi:10.1002/ana.21321 · Cited by 421
Self-citation
Metadata
- Authors
- Kanemitsu, H., Tomiyama, T., & Mori, H.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 350
- Issue
- 2
- Pages
- 113-116
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2054542987
- Cited by
- 228
- References
- 5
- FWCI
- 4.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Kanemitsu, H., Tomiyama, T., & Mori, H. (2003). Human neprilysin is capable of degrading amyloid β peptide not only in the monomeric form but also the pathological oligomeric form. Neuroscience Letters. https://doi.org/10.1016/s0304-3940(03)00898-x
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