The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain
Abstract
The effects of a high affinity cannabinoid receptor agonist were evaluated in rats subjected to chronic constriction injury of the sciatic nerve (CCI) or a sham operation. Intraperitoneal (i.p.) injections of the active, but not the inactive enantiomer, alleviated the pain behavior exhibited by CCI animals in a dose dependent manner. Moreover, at doses ranging from 0.43 to 4.3 mg/kg effects on sensitivity to a heat stimulus were observed neither in the paw contralateral to the sciatic ligation, nor in animals subjected to sham surgery. Animals subjected to CCI and treated with 4.3 mg/kg exhibited hypoalgesia in the paw ipsilateral to the ligated sciatic, i.e. heat hypoalgesia was completely reversed. The hypoalgesia is presumed to be the results of unmasking of a sensory deficit reflecting the known loss of C and A delta with CCI. Although side effects were present in some CCI animals subjected to the high dose (4.3 mg/kg), a moderate dose (2.14 mg/kg) completely alleviated the thermal and mechanical hyperalgesia, and mechanical allodynia without side effects. In addition to identifying a potential drug treatment for painful neuropathy, this study suggests that changes in cannabinoid receptors occurs in nerve injured animals.
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“SR141716, administered acutely, is pro-hyperalgesic and pro-allodynic in this model. 42”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [42]
Citations
Cites
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Dextrorphan relieves neuropathic heat-evoked hyperalgesia in the rat
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Further studies on the antinociceptive effects ofΔ acid
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Cited by
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Millan, M. J. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00009-6 · Cited by 3,035
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
Pacher, P., Bátkai, S., & Kunos, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.2 · Cited by 2,077
Role of Endogenous Cannabinoids in Synaptic Signaling
Freund, T. F., Katona, I., & Piomelli, D. (2003) · Physiological Reviews · doi:10.1152/physrev.00004.2003 · Cited by 1,616
Cannabinoid receptors and pain
Pertwee, R. G. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00031-9 · Cited by 741
Iversen, L. L. (2003) · Brain · doi:10.1093/brain/awg143 · Cited by 751
Metadata
- Authors
- Herzberg, U., Eliav, E., Bennett, G. J., & Kopin, I. J.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Herzberg, U
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1997-01
- Volume
- 221
- Issue
- 2-3
- Pages
- 157-160
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1968446992
- Cited by
- 307
- References
- 15
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 7 · 2019: 9 · 2018: 4 · 2017: 8 · 2016: 3 · 2015: 7 · 2014: 2 · 2013: 14 · 2012: 12
- FWCI
- 10.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- cannabinoid receptor agonists, neuropathic pain, chronic constriction injury, sciatic nerve, analgesia, mechanical allodynia, thermal hyperalgesia, mechanical hyperalgesia, enantiomer specificity
- MeSH terms
- Rimonabant, Animals, Cannabinoids, Hot Temperature, Hyperalgesia, Injections, Intraperitoneal, Male, Morpholines, Naphthalenes, Pain, Peripheral Nervous System Diseases, Piperidines, Pyrazoles, Receptors, Drug, Rats, Sprague-Dawley, Analgesics, Non-Narcotic, Receptors, Cannabinoid, Benzoxazines, Rats
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