Cited by 310Cannabis and Cannabinoid ResearchPain Mechanisms and TreatmentsPain Management and Treatment

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The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain

Herzberg, U, Eliav, E, Bennett, G.J, Kopin, Irwin J·1997·Neuroscience Letters

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Abstract

The effects of a high affinity cannabinoid receptor agonist were evaluated in rats subjected to chronic constriction injury of the sciatic nerve (CCI) or a sham operation. Intraperitoneal (i.p.) injections of the active, but not the inactive enantiomer, alleviated the pain behavior exhibited by CCI animals in a dose dependent manner. Moreover, at doses ranging from 0.43 to 4.3 mg/kg effects on sensitivity to a heat stimulus were observed neither in the paw contralateral to the sciatic ligation, nor in animals subjected to sham surgery. Animals subjected to CCI and treated with 4.3 mg/kg exhibited hypoalgesia in the paw ipsilateral to the ligated sciatic, i.e. heat hypoalgesia was completely reversed. The hypoalgesia is presumed to be the results of unmasking of a sensory deficit reflecting the known loss of C and A delta with CCI. Although side effects were present in some CCI animals subjected to the high dose (4.3 mg/kg), a moderate dose (2.14 mg/kg) completely alleviated the thermal and mechanical hyperalgesia, and mechanical allodynia without side effects. In addition to identifying a potential drug treatment for painful neuropathy, this study suggests that changes in cannabinoid receptors occurs in nerve injured animals.

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Authors: Herzberg, U., Eliav, E., Bennett, G. J., & Kopin, I. J.
Affiliations: National Institutes of Health (US)
Corresponding author: Herzberg, U
ORCID: Herzberg, U
Eliav, E
Kopin, Irwin J
Venue: Neuroscience Letters
Publisher: Elsevier BV
Published: 1997-01
Volume: 221
Issue: 2-3
Pages: 157-160
ISSN: 0304-3940 (ISSN-L)
DOI: 10.1016/s0304-3940(96)13308-5
OpenAlex: W1968446992
Cited by: 307
References: 15
Citations by year: 2026: 2 · 2025: 6 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 7 · 2019: 9 · 2018: 4 · 2017: 8 · 2016: 3 · 2015: 7 · 2014: 2 · 2013: 14 · 2012: 12
FWCI: 10.32
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: cannabinoid receptor agonists, neuropathic pain, chronic constriction injury, sciatic nerve, analgesia, mechanical allodynia, thermal hyperalgesia, mechanical hyperalgesia, enantiomer specificity
MeSH terms: Rimonabant, Animals, Cannabinoids, Hot Temperature, Hyperalgesia, Injections, Intraperitoneal, Male, Morpholines, Naphthalenes, Pain, Peripheral Nervous System Diseases, Piperidines, Pyrazoles, Receptors, Drug, Rats, Sprague-Dawley, Analgesics, Non-Narcotic, Receptors, Cannabinoid, Benzoxazines, Rats

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The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain

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