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Age-related changes in the regulation of transcription factor NF-κB in rat brain
Abstract
Aging process involves an increase in stress at cellular level. We studied whether aging affects the regulation of stress responsive transcription factor NF-kappa B in brain samples of Wistar rats. Hippocampus, cerebellum, and temporal and frontal lobes of cortex were studied. We observed a significant up-regulation in the constitutive, nucleus-located NF-kappa B binding activity in 30-month-old Wistar rats compared to young and 18-month-old rats. The increase was most prominent in cerebellum and in frontal cortex, but age-related changes did not occur in hippocampus. Inducible, cytoplasmic NF-kappa B binding activity was not affected by aging in any of the samples studied. Western blot assays did not show any age-related changes in the nuclear level of p50, p52, and p65 protein components of NF-kappa B complex. Cytoplasmic level of inhibitory I kappa B-alpha was also unaffected. The increase in nuclear constitutive NF-kappa B binding activity during aging may be related to the NF-kappa B driven cellular response to adapt neurons against apoptotic pressure, as observed recently in several apoptotic conditions.
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“This morphological profile of the aged microglia first reported in rats has also been confirmed in mice, gerbils, and dogs (Hwang et al, 2008;Korhonen et al, 1997;Norden and Godbout, 2013;Streit and Xue, 2010).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Korhonen et al, 1997
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Cites
Suppression of TNF-α-Induced Apoptosis by NF-κB
Antwerp, D. J. V., Martin, S. J., Kafri, T., Green, D. R., & Verma, I. M. (1996) · Science · doi:10.1126/science.274.5288.787 · Cited by 2,581
Structure, Regulation and Function of NF-kappaB
Siebenlist, U. K., Franzoso, G., & Brown, K. D. (1994) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.10.110194.002201 · Cited by 2,086
Aging, energy, and oxidative stress in neurodegenerative diseases
Beal, M. F. (1995) · Annals of Neurology · doi:10.1002/ana.410380304 · Cited by 1,434
Schreck, R., Albermann, K., & Baeuerle, P. A. (1992) · Free Radical Research Communications · doi:10.3109/10715769209079515 · Cited by 1,388
Genetic analysis of ageing: role of oxidative damage and environmental stresses
Martin, G. M., Austad, S. N., & Johnson, T. E. (1996) · Nature Genetics · doi:10.1038/ng0596-25 · Cited by 646
Constitutive NF-kB Activity in Neurons
Kaltschmidt, C., Kaltschmidt, B., Neumann, H., Wekerle, H., & Baeuerle, P. A. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.6.3981-3992.1994 · Cited by 398
Constitutive NF-kappa B activity in neurons.
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Guerrini, L., Blasi, F., & Denis‐Donini, S. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9077 · Cited by 287
Helenius, M., Hänninen, M., Lehtinen, S. K., & Salminen, A. (1996) · Biochemical Journal · doi:10.1042/bj3180603 · Cited by 233
Self-citationGoodman, Y., & Mattson, M. P. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66020869.x · Cited by 231
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“Furthermore, chronic activation of NF-κB has been observed in the skin, kidneys, cardiac muscles, and brain tissues (Helenius et al. 1996; Korhonen et al. 1997; Chung et al. 1999; Tilstra et al. 2012; Zhang et al. 2013).”
Sánchez (2002) · doi:10.1379/1466-1268(2002)007
Metadata
- Authors
- Korhonen, P., Helenius, M., & Salminen, A.
- Affiliations
- University of Eastern Finland (FI)
- University of Jyväskylä (FI)
- Corresponding author
- Salminen, A
- ORCID
- Salminen, A
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1997-03
- Volume
- 225
- Issue
- 1
- Pages
- 61-64
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1979437866
- Cited by
- 138
- References
- 18
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 6 · 2021: 3 · 2020: 7 · 2019: 2 · 2018: 7 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 4 · 2013: 8 · 2012: 12
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- NF-κB, brain aging, hippocampus, cerebellum, cerebral cortex, IκBα, neuronal apoptosis, stress response, Wistar rats
- MeSH terms
- Aging, Animals, Brain, Cell Nucleus, Cerebellum, Female, Frontal Lobe, Gene Expression Regulation, Hippocampus, Male, Nerve Tissue Proteins, Protein Binding, Temporal Lobe, Up-Regulation, NF-kappa B, Rats, Wistar, Rats
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