The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Age-related changes in the regulation of transcription factor NF-κB in rat brain
Abstract
Aging process involves an increase in stress at cellular level. We studied whether aging affects the regulation of stress responsive transcription factor NF-kappa B in brain samples of Wistar rats. Hippocampus, cerebellum, and temporal and frontal lobes of cortex were studied. We observed a significant up-regulation in the constitutive, nucleus-located NF-kappa B binding activity in 30-month-old Wistar rats compared to young and 18-month-old rats. The increase was most prominent in cerebellum and in frontal cortex, but age-related changes did not occur in hippocampus. Inducible, cytoplasmic NF-kappa B binding activity was not affected by aging in any of the samples studied. Western blot assays did not show any age-related changes in the nuclear level of p50, p52, and p65 protein components of NF-kappa B complex. Cytoplasmic level of inhibitory I kappa B-alpha was also unaffected. The increase in nuclear constitutive NF-kappa B binding activity during aging may be related to the NF-kappa B driven cellular response to adapt neurons against apoptotic pressure, as observed recently in several apoptotic conditions.
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“This morphological profile of the aged microglia first reported in rats has also been confirmed in mice, gerbils, and dogs (Hwang et al, 2008;Korhonen et al, 1997;Norden and Godbout, 2013;Streit and Xue, 2010).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Korhonen et al, 1997
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Cites
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Molecular inflammation: Underpinnings of aging and age-related diseases
Chung, H. Y., Cesari, M., Anton, S., Marzetti, E., Giovannini, S., Seo, A. Y., Carter, C., Yu, B. P., & Leeuwenburgh, C. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2008.07.002 · Cited by 1,203
“Korhonen et al. (1997) also reported a significant upregulation of NF-κB in the rat brain.”
BackgroundKawahara, T. L. A., Michishita, E., Adler, A. S., Damian, M., Berber, E., Lin, M., McCord, R. A., Ongaigui, K. C. L., Boxer, L. D., Chang, H. Y., et al. (2009) · Cell · doi:10.1016/j.cell.2008.10.052 · Cited by 1,090
Sivandzade, F., Prasad, S., Bhalerao, A., & Cucullo, L. (2019) · Redox Biology · doi:10.1016/j.redox.2018.11.017 · Cited by 639
Salminen, A., Huuskonen, J., Ojala, J., Kauppinen, A., Kaarniranta, K., & Suuronen, T. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2007.09.002 · Cited by 581
Self-citationOxidative stress and vascular inflammation in aging
Assar, M. E., Angulo, J., & Rodríguez‐Mañas, L. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.07.003 · Cited by 591
Metadata
- Authors
- Korhonen, P., Helenius, M., & Salminen, A.
- Affiliations
- University of Eastern Finland (FI)
- University of Jyväskylä (FI)
- Corresponding author
- Salminen, A
- ORCID
- Salminen, A
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1997-03
- Volume
- 225
- Issue
- 1
- Pages
- 61-64
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1979437866
- Cited by
- 138
- References
- 18
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 6 · 2021: 3 · 2020: 7 · 2019: 2 · 2018: 7 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 4 · 2013: 8 · 2012: 12
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- NF-κB, brain aging, hippocampus, cerebellum, cerebral cortex, IκBα, neuronal apoptosis, stress response, Wistar rats
- MeSH terms
- Aging, Animals, Brain, Cell Nucleus, Cerebellum, Female, Frontal Lobe, Gene Expression Regulation, Hippocampus, Male, Nerve Tissue Proteins, Protein Binding, Temporal Lobe, Up-Regulation, NF-kappa B, Rats, Wistar, Rats
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