Cited by 138NF-κB Signaling PathwaysGenetics, Aging, and Longevity in Model OrganismsNeuroinflammation and Neurodegeneration Mechanisms

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Age-related changes in the regulation of transcription factor NF-κB in rat brain

Korhonen, P, Helenius, M, Salminen, A·1997·Neuroscience Letters

DOI 10.1016/s0304-3940(97)00190-0

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Abstract

Aging process involves an increase in stress at cellular level. We studied whether aging affects the regulation of stress responsive transcription factor NF-kappa B in brain samples of Wistar rats. Hippocampus, cerebellum, and temporal and frontal lobes of cortex were studied. We observed a significant up-regulation in the constitutive, nucleus-located NF-kappa B binding activity in 30-month-old Wistar rats compared to young and 18-month-old rats. The increase was most prominent in cerebellum and in frontal cortex, but age-related changes did not occur in hippocampus. Inducible, cytoplasmic NF-kappa B binding activity was not affected by aging in any of the samples studied. Western blot assays did not show any age-related changes in the nuclear level of p50, p52, and p65 protein components of NF-kappa B complex. Cytoplasmic level of inhibitory I kappa B-alpha was also unaffected. The increase in nuclear constitutive NF-kappa B binding activity during aging may be related to the NF-kappa B driven cellular response to adapt neurons against apoptotic pressure, as observed recently in several apoptotic conditions.

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“…increased basal levels of nitric oxide, heat shock proteins (HSPs) and Nuclear Factor kappa B (NFjB) found in aged (Calabrese et al., 2004; Korhonen et al., 1997; Toliver-Kinsky et al., 1997), have all been related to an increased resistance to ischemic damage (Dirnagl et al., 2003) and…”
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“For example, upregulation of the NFjB pathway in aged animals and older humans has been demonstrated in multiple tissues such as skeletal muscle, liver, kidney, heart, and gastric mucosa (Helenius et al., 1996; Korhonen et al., 1997; Walter & Sierra, 1998; Xiao & Majumdar, 2000; Ghosh et al., 2015).”
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“Although an increase in the DNA binding activity of NFjB is reported in the tissues of the aged animals, no increase in the levels of NFjB during aging has been reported (Helenius et al. 1996; Korhonen et al. 1997).”
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Authors: Korhonen, P., Helenius, M., & Salminen, A.
Affiliations: University of Eastern Finland (FI)
University of Jyväskylä (FI)
Corresponding author: Salminen, A
ORCID: Salminen, A
Venue: Neuroscience Letters
Publisher: Elsevier BV
Published: 1997-03
Volume: 225
Issue: 1
Pages: 61-64
ISSN: 0304-3940 (ISSN-L)
DOI: 10.1016/s0304-3940(97)00190-0
OpenAlex: W1979437866
Cited by: 138
References: 18
Citations by year: 2026: 2 · 2024: 2 · 2023: 6 · 2021: 3 · 2020: 7 · 2019: 2 · 2018: 7 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 4 · 2013: 8 · 2012: 12
FWCI: 0.56
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: NF-κB, brain aging, hippocampus, cerebellum, cerebral cortex, IκBα, neuronal apoptosis, stress response, Wistar rats
MeSH terms: Aging, Animals, Brain, Cell Nucleus, Cerebellum, Female, Frontal Lobe, Gene Expression Regulation, Hippocampus, Male, Nerve Tissue Proteins, Protein Binding, Temporal Lobe, Up-Regulation, NF-kappa B, Rats, Wistar, Rats

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Age-related changes in the regulation of transcription factor NF-κB in rat brain

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