Increased plasma amyloid β protein 1–42 levels in Down syndrome
Abstract
Amyloid beta protein 1-40 (A beta40) and A beta42 levels were quantitated in plasma from 43 persons with Down syndrome (DS; 26-68 years of age), 43 age-matched normal controls, and 19 non-DS mentally retarded (MR) persons (26-91 years of age) by using a sandwich enzyme linked immunosorbent assay. A beta40 levels were higher in DS and MR than controls, but were similar between DS and MR groups. A beta42 levels were higher in DS than controls or MR persons. The ratios of A beta42/A beta40 were higher in DS than controls or MR persons. The findings are consistent with those seen in DS brains.
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- Authors
- Mehta, P. D., Dalton, A. J., Mehta, S. P., Kim, K. S., Sersen, E. A., & Wisniewski, H. M.
- Corresponding author
- Mehta, Pankaj D
- ORCID
- Mehta, Pankaj D
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1998-01
- Volume
- 241
- Issue
- 1
- Pages
- 13-16
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2057996446
- Semantic Scholar
- a454da7eead23895f0d212c2c93a8279711de539
- Cited by
- 108
- References
- 18
- Citations by year
- 2024: 1 · 2021: 3 · 2019: 5 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 16.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ag011290-05)
- National Institute on Aging (AG11290)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Down syndrome, amyloid-beta, amyloid-beta 42, Aβ40, plasma biomarkers, intellectual disability, Alzheimer's disease
- MeSH terms
- Adult, Aged, Aged, 80 and over, Down Syndrome, Female, Humans, Male, Intellectual Disability, Middle Aged, Peptide Fragments, Trisomy, Amyloid beta-Peptides, Gene Dosage
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