Hippocampal atrophy secondary to entorhinal cortical degeneration in Alzheimer-type dementia
Abstract
Pathological comparison between cases with Alzheimer-type dementia (ATD) and the non-demented cases with infarct showed that hippocampal atrophy in ATD could be caused mainly by degeneration of the stratum lacunosum-radiatum rather than neuronal loss in the pyramidal layer of the hippocampus, and that degeneration of the stratum lacunosum-radiatum could be secondary mainly to the entorhinal cortical degeneration.
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There is no consensus about which hippocampal subfields become atrophic earliest in AD or which neuropathological change is primarily implicated in volume reduction.
“There is no consensus about which hippocampal subfields become atrophic earliest in the course of Alzheimer's disease (AD).”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [15]
Our finding of particularly severe volume reduction of subicular complex in AD is consistent with neuropathological observations made by Mizutani and Kasahara.
“Our finding of a particularly severe volume reduction of the subicular complex in AD is consistent with the neuropathological observations made by Mizutani and Kasahara [15], [16].”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [15]
Mizutani and Kasahara attributed severe volume loss of these structures to isomorphic fibrillary gliosis resulting from early and severe degeneration of the perforant pathway while penetrating the hippocampus through the subicular field.
“They attributed the particularly severe volume loss of these structures to isomorphic fibrillary gliosis resulting from early and severe degeneration of the perforant pathway while penetrating the hippocampus through the subicular field, in its course from the entorhinal cortex to the dentate gyrus.”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [15]
Mizutani and Kasahara reported disproportionate atrophy in subicular complex with respect to Ammon's horn fields and dentate gyrus in AD.
“These authors investigating an autoptical series of AD patients reported disproportionate atrophy in the subicular complex with respect to Ammon's horn fields (CA1, 2, 3, and 4) and the dentate gyrus.”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [15]
This finding probably reflects severe degeneration of the perforant pathway while penetrating the hippocampus through the subicular field in its course from entorhinal cortex to dentate gyrus.
“This finding is consistent with neuropathological observations in AD patients and probably reflects the severe degeneration of the perforant pathway while penetrating the hippocampus through the subicular field in its course from the entorhinal cortex to the dentate gyrus.”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [15]
Mizutani and Kasahara noted that atrophic subiculum showed marked loss of pyramidal neurons, whereas hippocampus proper showed only slight loss.
“Mizutani and Kasahara [15] also noted that the atrophic subiculum showed marked loss of pyramidal neurons, whereas the hippocampus proper showed only a slight loss of neurons.”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [15]
The finding of prevalent presubicular-subicular atrophy is consistent with neuropathological observations in AD patients.
“This finding is consistent with neuropathological observations in AD patients [15], [16]”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [15]
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A NEW DEFINITION OF ALZHEIMER'S DISEASE: A HIPPOCAMPAL DEMENTIA
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Hippocampal CA1 apical neuropil atrophy in mild Alzheimer disease visualized with 7-T MRI
Kerchner, G. A., Hess, C. P., Hammond-Rosenbluth, K. E., Xu, D., Rabinovici, G. D., Kelley, D. A. C., Vigneron, D. B., Nelson, S. J., & Miller, B. L. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f736a1 · Cited by 193 · see citing works
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Automated Segmentation of Hippocampal Subfields in Drug-Naïve Patients with Alzheimer Disease
Lim, H. K., Hong, S. C., Jung, W. S., Ahn, K. J., Won, W. Y., Hahn, C., Kim, I. S., & Lee, C. U. (2013) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3293 · Cited by 52 · see citing works
- Authors
- Mizutani, T., & Kasahara, M.
- Affiliations
- Tokyo Metropolitan Institute of Gerontology (JP)
- Komagino Hospital (JP)
- Corresponding author
- Mizutani, Toshio
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1997-01
- Volume
- 222
- Issue
- 2
- Pages
- 119-122
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2056123459
- Cited by
- 53
- References
- 13
- Citations by year
- 2026: 1 · 2024: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 6
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- hippocampal atrophy, Alzheimer-type dementia, pyramidal layer, neuronal loss, infarction
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Female, Hippocampus, Humans, Nerve Degeneration, Entorhinal Cortex
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