Degeneration of the intrahippocampal routes of the perforant and alvear pathways in senile dementia of Alzheimer type
Abstract
In five autopsied brains with senile dementia of Alzheimer type, the intrahippocampal routes of the perforant and alvear pathways were demonstrated by assessment of the distribution of isomorphic gliosis. Our results suggest that the perforant pathway goes along the stratum lacunosum-moleculare of the hippocampus proper to end in the dentate gyrus after perforating the prosubiculum but does not traverse the hippocampal sulcus, and that the alvear pathway enters into the stratum oriens of the hippocampus proper and the alveus from the white matter ventral to the subiculum.
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Neuronal loss in subicular field further compromises anatomical and functional communication of hippocampus with extrahippocampal connected regions.
“On the other side, the neuronal loss in the subicular field [13], [16] further compromises the anatomical and functional communication of the hippocampus with extrahippocampal connected regions.”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [16]
Our finding of particularly severe volume reduction of subicular complex in AD is consistent with neuropathological observations made by Mizutani and Kasahara.
“Our finding of a particularly severe volume reduction of the subicular complex in AD is consistent with the neuropathological observations made by Mizutani and Kasahara [15], [16].”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [16]
Mizutani and Kasahara attributed severe volume loss of these structures to isomorphic fibrillary gliosis resulting from early and severe degeneration of the perforant pathway while penetrating the hippocampus through the subicular field.
“They attributed the particularly severe volume loss of these structures to isomorphic fibrillary gliosis resulting from early and severe degeneration of the perforant pathway while penetrating the hippocampus through the subicular field, in its course from the entorhinal cortex to the dentate gyrus.”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [16]
Mizutani and Kasahara reported disproportionate atrophy in subicular complex with respect to Ammon's horn fields and dentate gyrus in AD.
“These authors investigating an autoptical series of AD patients reported disproportionate atrophy in the subicular complex with respect to Ammon's horn fields (CA1, 2, 3, and 4) and the dentate gyrus.”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [16]
This finding probably reflects severe degeneration of the perforant pathway while penetrating the hippocampus through the subicular field in its course from entorhinal cortex to dentate gyrus.
“This finding is consistent with neuropathological observations in AD patients and probably reflects the severe degeneration of the perforant pathway while penetrating the hippocampus through the subicular field in its course from the entorhinal cortex to the dentate gyrus.”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [16]
The finding of prevalent presubicular-subicular atrophy is consistent with neuropathological observations in AD patients.
“This finding is consistent with neuropathological observations in AD patients [15], [16]”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [16]
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Carlesimo, G. A., Piras, F., Orfei, M. D., Iorio, M., Caltagirone, C., & Spalletta, G. (2015) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1016/j.dadm.2014.12.001 · Cited by 159 · see citing works
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Hippocampal atrophy secondary to entorhinal cortical degeneration in Alzheimer-type dementia
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Self-citation
- Authors
- Mizutani, T., & Kasahara, M.
- Affiliations
- Tokyo Metropolitan Institute of Gerontology (JP)
- Komagino Hospital (JP)
- Corresponding author
- Mizutani, Toshio
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1995-01
- Volume
- 184
- Issue
- 2
- Pages
- 141-144
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2045426954
- Cited by
- 38
- References
- 17
- Citations by year
- 2024: 1 · 2020: 1 · 2019: 1 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- senile dementia of the Alzheimer type, perforant path, hippocampus, dentate gyrus, stratum lacunosum-moleculare, stratum oriens, alveus, subiculum, white matter, neurodegeneration
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Cerebral Ventricles, Female, Gliosis, Hippocampus, Humans, Male, Nerve Degeneration, Neural Pathways, Entorhinal Cortex
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