The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
The d- and l- isomers of methadone bind to the non-competitive site on the N-methyl-d-aspartate (NMDA) receptor in rat forebrain and spinal cord
Open accessAbstract
Racemic (dl)-methadone has antagonist activity at the N-methyl-D-aspartate (NMDA) receptor. We evaluated dl-methadone, the opioid active (l-) and the opioid inactive (d-) isomers in competition binding assays. dl-Methadone and its d- and l- isomers exhibited low micromolar affinities for the [3H]MK-801-labeled non-competitive site of the NMDA receptor in both rat forebrain and spinal cord synaptic membranes, with Ki values and displacement curves similar to those of dextromethorphan, an established NMDA receptor antagonist. They lacked affinity at the [3H]CGS-19755-labeled competitive site of the NMDA receptor. Therefore, both methadone and its the d- and l- isomers differ from morphine, hydromorphone, and naltrexone in that they have non-competitive antagonist activity at the NMDA receptor. A non-opioid NMDA receptor antagonist, such as d-methadone, may improve the efficacy of morphine by attenuating the development of tolerance.
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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
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[3H]MK‐801 Labels a Site on the N‐Methyl‐D‐Aspartate Receptor Channel Complex in Rat Brain Membranes
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Cited by
Maltoni, M., Caraceni, A., Brunelli, C., Broeckaert, B., Christakis, N., Eychmueller, S., Glare, P., Nabal, M., Viganò, A., Larkin, P., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.06.866 · Cited by 664
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Opioids versus antidepressants in postherpetic neuralgia: A randomized, placebo-controlled trial
Raja, S. N., Haythornthwaite, J. A., Pappagallo, M., Clark, M. R., Travison, T. G., Sabeen, S., Royall, R. M., & Max, M. B. (2002) · Neurology · doi:10.1212/wnl.59.7.1015 · Cited by 593
Mu Opioids and Their Receptors: Evolution of a Concept
Pasternak, G. W., & Pan, Y.-X. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.007138 · Cited by 578
Moulin, D., Boulanger, A., Clark, A., Clarke, H., Dao, T., Finley, G., Furlan, A., Gilron, I., Gordon, A., Morley-Forster, P., et al. (2014) · Pain Research and Management · doi:10.1155/2014/754693 · Cited by 529
Metadata
- Authors
- Laurel Gorman, A., Elliott, K. J., & Inturrisi, C. E.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1997-02
- Volume
- 223
- Issue
- 1
- Pages
- 5-8
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2094957254
- Cited by
- 398
- References
- 18
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: The d- and l- isomers of methadone bind to the non-competitive site on the N-methyl-d-aspartate (NMDA) receptor in rat forebrain and spinal cord. https://app.cochat.ai/papers/10.1016/s0304-3940(97)13391-2
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- Laurel Gorman, A., Elliott, K. J., & Inturrisi, C. E. (1997). The d- and l- isomers of methadone bind to the non-competitive site on the N-methyl-d-aspartate (NMDA) receptor in rat forebrain and spinal cord. Neuroscience Letters. https://doi.org/10.1016/s0304-3940(97)13391-2
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
