Priming stimulation in the basolateral amygdala modulates synaptic plasticity in the rat dentate gyrus
Abstract
We investigated the effects of basolateral amygdala (BLA) priming on long-term potentiation (LTP) in the dentate gyrus (DG). In the control animals, the induction of high-frequency stimulation (HFS) to the perforant path (PP) resulted in hippocampal LTP at all the time intervals tested. A priming stimulation to the BLA prior to the application of HFS to the PP resulted in the enhancement of the excitatory post-synaptic potential (EPSP)-LTP and population spike (PS)-LTP in the DG from 90-min post-HFS onwards. These findings suggest that the amygdala has a potential role in the modulation of some aspects of memory that are mediated by the hippocampus.
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Electrical stimulation of the amygdala can mimic the emotion-induced enhancement of hippocampal LTP.
“Electrical stimulation of the amygdala can mimic the emotion-induced enhancement of hippocampal LTP (Ikegaya et al. [210]; Akirav and Richter-Levin [148]; Akirav and Richter-Levin [211]; Frey et al. [212]; Akirav and Richter-Levin [213])”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Akirav and Richter-Levin [211]
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Declarative and Nondeclarative Memory: Multiple Brain Systems Supporting Learning and Memory
Squire, L. R. (1992) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1992.4.3.232 · Cited by 1,282 · see citing works
Miserendino, M. J. D., Sananes, C. B., Melia, K. R., & Davis, M. (1990) · Nature · doi:10.1038/345716a0 · Cited by 824 · see citing works
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Diamond, D. M., Campbell, A. M., Park, C. R., Halonen, J., & Zoladz, P. R. (2007) · Neural Plasticity · doi:10.1155/2007/60803 · Cited by 762 · see citing works
“Our findings are consistent with recent work from other laboratories indicating that acute stress or corticosterone administration blocks hippocampal LTP (Shors et al. [141]; Shors and Thompson [142]; Pavlides et al. [143]; Pavlides et al. [144]; Pavlides et al. [145]; Garcia et al. [146]; Pavlides and McEwen [147]; Ak…”
BackgroundMethodInfluentialDiamond, D. M., Park, C. R., & Woodson, J. C. (2004) · Hippocampus · doi:10.1002/hipo.10186 · Cited by 95 · see citing works
Amygdala modulation of memory-related processes in the hippocampus: potential relevance to PTSD
Tsoory, M. M., Vouimba, R. M., Akirav, I., Kavushansky, A., Avital, A., & Richter-Levin, G. (2007) · Progress in Brain Research · doi:10.1016/s0079-6123(07)67003-4 · Cited by 78 · see citing works
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- Authors
- Akirav, I., & Richter-Levin, G.
- Affiliations
- University of Haifa (IL)
- ORCID
- Akirav, Irit
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1999-07
- Volume
- 270
- Issue
- 2
- Pages
- 83-86
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2166135425
- Cited by
- 72
- References
- 2
- Citations by year
- 2025: 1 · 2024: 3 · 2022: 3 · 2021: 3 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 7
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- basolateral amygdala, long-term potentiation, dentate gyrus, perforant path, hippocampus, synaptic plasticity, excitatory postsynaptic potentials, population spike, memory modulation
- MeSH terms
- Action Potentials, Amygdala, Animals, Electric Stimulation, Male, Neuronal Plasticity, Synapses, Time Factors, Rats, Sprague-Dawley, Long-Term Potentiation, Dentate Gyrus, Perforant Pathway, Excitatory Postsynaptic Potentials, Rats
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