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Cited by 78Memory and Neural MechanismsPosttraumatic Stress Disorder ResearchStress Responses and Cortisol

Amygdala modulation of memory-related processes in the hippocampus: potential relevance to PTSD

Tsoory, M.M., Vouimba, R.M., Akirav, I., Kavushansky, A., Avital, A., Richter-Levin, G.·2007·Progress in Brain Research
DOI 10.1016/s0079-6123(07)67003-4
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Abstract

A key assumption in the study of stress-induced cognitive and neurobiological modifications is that alterations in hippocampal functioning after stress are due to an excessive activity exerted by the amygdala on the hippocampus. Research so far focused on stress-induced impairment of hippocampal plasticity and memory but an exposure to stress may simultaneously also result in strong emotional memories. In fact, under normal conditions emotionally charged events are better remembered compared with neutral ones. Results indicate that under these conditions there is an increase in activity within the amygdala that may lead to memory of a different quality. Studying the way emotionality activates the amygdala and the functional impact of this activation we found that the amygdala modulates memory-related processes in other brain areas, such as the hippocampus. However, this modulation is complex, involving both enhancing and suppressing effects, depending on the way the amygdala is activated and the hippocampal subregion examined. The current review summarizes our findings and attempts to put them in context with the impact of an exposure to a traumatic experience, in which there is a mixture of a strong memory of some aspects of the experience but impaired memory of other aspects of that experience. Toward that end, we have recently developed an animal model for the induction of predisposition to stress-related disorders, focusing on the consequences of exposure to stressors during juvenility on the ability to cope with stress in adulthood. Exposing juvenile-stressed rats to an additional stressful challenge in adulthood revealed their impairment to cope with stress and resulted in significant elevation of the amygdala. Interestingly, and similar to our electrophysiological findings, differential effects were observed between the impact of the emotional challenge on CA1 and dentate gyrus subregions of the hippocampus. Taken together, the results indicate that long-term alterations within the amygdala contribute to stress-related mnemonic symptoms and suggest that elucidating further these intra-amygdala alterations and their effects on modulating other brain regions is likely to be beneficial for the development of novel approaches to treat stress-related disorders.

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Authors
Tsoory, M. M., Vouimba, R. M., Akirav, I., Kavushansky, A., Avital, A., & Richter-Levin, G.
Affiliations
University of Haifa (IL)
ORCID
Venue
Progress in Brain Research
Publisher
Elsevier
Published
2007
Volume
167
Pages
35-51
ISSN
0079-6123 (ISSN-L)
DOI
10.1016/s0079-6123(07)67003-4
OpenAlex
W1524765250
Cited by
78
References
82
Citations by year
2026: 1 · 2024: 2 · 2023: 1 · 2022: 6 · 2021: 1 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 6 · 2012: 7
FWCI
10.38
Type
book chapter
Language
en
Open access
closed
Locations
  • Progress in brain research (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Alliance for Research on Schizophrenia and Depression
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
amygdala, hippocampus, post-traumatic stress disorder, stress-induced memory impairment, emotional memory, hippocampal subfields, CA1, dentate gyrus, stress coping, stress-related disorders
MeSH terms
Amygdala, Animals, Hippocampus, Humans, Memory, Stress Disorders, Post-Traumatic

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