The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Orexin-A, an hypothalamic peptide with analgesic properties
Abstract
The hypothalamic peptide orexin-A and the orexin-1 receptor are localized in areas of the brain and spinal cord associated with nociceptive processing. In the present study, localization was confirmed in the spinal cord and demonstrated in the dorsal root ganglion for both orexin-A and the orexin-1 receptor. The link with nociception was extended when orexin-A was shown to be analgesic when given i.v. but not s.c. in mouse and rat models of nociception and hyperalgesia. The efficacy of orexin-A was similar to that of morphine in the 50 degrees C hotplate test and the carrageenan-induced thermal hyperalgesia test. However, involvement of the opiate system in these effects was ruled out as they were blocked by the orexin-1 receptor antagonist SB-334867 but not naloxone. Orexin-1 receptor antagonists had no effect in acute nociceptive tests but under particular inflammatory conditions were pro-hyperalgesic, suggesting a tonic inhibitory orexin drive in these circumstances. These data demonstrate that the orexinergic system has a potential role in the modulation of nociceptive transmission.
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Cites
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A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
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Neurons containing hypocretin (orexin) project to multiple neuronal systems
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Orexin A activates locus coeruleus cell firing and increases arousal in the rat
Hagan, J. J., Leslie, R. A., Patel, S., Evans, M. L., Wattam, T. A., Holmes, S., Benham, C. D., Taylor, S. G., Routledge, C., Hemmati, P., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.19.10911 · Cited by 1,234
Self-citationHypothalamic Hypocretin (Orexin): Robust Innervation of the Spinal Cord
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Orexin A but Not Orexin B Rapidly Enters Brain from Blood by Simple Diffusion
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Feeding response to central orexins
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Cited by
The hypocretins: Setting the arousal threshold
Sutcliffe, J. G., & de Lecea, L. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn808 · Cited by 422
Pain in the brain: are hormones to blame?
Blackburn-Munro, G., & Blackburn-Munro, R. (2003) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(02)00004-8 · Cited by 124
Metadata
- Authors
- Bingham, S., Davey, P. T., Babbs, A. J., Irving, E. A., Sammons, M. J., Wyles, M., Jeffrey, P., Cutler, L., Riba, I., Johns, A., Porter, R. A., Upton, N., Hunter, A. J., & Parsons, A. A.
- Venue
- Pain
- Published
- 2001-05
- Volume
- 92
- Issue
- 1
- Pages
- 81-90
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2008099612
- Cited by
- 268
- References
- 27
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bingham, S., Davey, P. T., Babbs, A. J., Irving, E. A., Sammons, M. J., Wyles, M., Jeffrey, P., Cutler, L., Riba, I., Johns, A., Porter, R. A., Upton, N., Hunter, A. J., & Parsons, A. A. (2001). Orexin-A, an hypothalamic peptide with analgesic properties. Pain. https://doi.org/10.1016/s0304-3959(00)00470-x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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