The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Hypothalamic Hypocretin (Orexin): Robust Innervation of the Spinal Cord
Open accessAbstract
Hypocretin (orexin) is synthesized by neurons in the lateral hypothalamus and has been reported to increase food intake and regulate the neuroendocrine system. In the present paper, long descending axonal projections that contain hypocretin were found that innervate all levels of the spinal cord from cervical to sacral segments, as studied in mouse, rat, and human spinal cord and not previously described. High densities of axonal innervation are found in regions of the spinal cord related to modulation of sensation and pain, notably in the marginal zone (lamina 1). Innervation of the intermediolateral column and lamina 10 as well as strong innervation of the caudal region of the sacral cord suggest that hypocretin may participate in the regulation of both the sympathetic and parasympathetic parts of the autonomic nervous system. Double-labeling experiments in mice combining retrograde transport of diamidino yellow after spinal cord injections and immunocytochemistry support the concept that hypocretin-immunoreactive fibers in the cord originate from the neurons in the lateral hypothalamus. Digital-imaging physiological studies with fura-2 detected a rise in intracellular calcium in response to hypocretin in cultured rat spinal cord neurons, indicating that spinal cord neurons express hypocretin-responsive receptors. A greater number of cervical cord neurons responded to hypocretin than another hypothalamo-spinal neuropeptide, oxytocin. These data suggest that in addition to possible roles in feeding and endocrine regulation, the descending hypocretin fiber system may play a role in modulation of sensory input, particularly in regions of the cord related to pain perception and autonomic tone.
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Cited by
Narcolepsy in orexin Knockout Mice
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Pathophysiology of migraine: a disorder of sensory processing
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Differential expression of orexin receptors 1 and 2 in the rat brain
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Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area
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Metadata
- Authors
- van den Pol, A. N.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1999-04-15
- Volume
- 19
- Issue
- 8
- Pages
- 3171-3182
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2115902692
- Cited by
- 526
- References
- 52
- FWCI
- 16.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- van den Pol, A. N. (1999). Hypothalamic Hypocretin (Orexin): Robust Innervation of the Spinal Cord. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.19-08-03171.1999
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
