The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Osteoarthritis and its association with muscle hyperalgesia: an experimental controlled study
Abstract
Hypertonic saline effectively excites muscle nociceptors. Muscle hyperalgesia was assessed in osteoarthritis (OA) by intramuscular infusion of 0.5 ml hypertonic saline (6%) into the tibialis anterior muscle in humans. Patients (n=14) with OA in the lower extremities were compared with an equal number of age- and sex-matched healthy controls. Ten of the 14 OA patients had pain in the knee joint as the most common presenting complaint. Visual analogue scale (VAS) pain intensity and assessment of pain areas were recorded before infusion and immediately, 2, 5, 10 and 20 min after infusion, and then every 10 min, until the pain vanished. The mean pain offset time in OA patients (11.3+/-7.9 min) was larger as compared with the control subjects (6.04+/-2.1 min) (P=0.025). OA patients had increased pain intensity VAS after the infusion in the right leg compared with controls (P<0.05). Referred and radiating pain areas at 2 min post-infusion increased in OA patients and not in controls as compared with the local pain areas (P<0.05). It is concluded that muscle hyperalgesia and extended pain areas might be due to central sensitization caused by painful osteoarthritis.
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Cites
Bonica, J. J., Melzack, R., & Wall, P. D. (1999) · Cited by 2,537
Coderre, T. J., Katz, J., Vaccarino, A. L., & Melzack, R. (1993) · Pain · doi:10.1016/0304-3959(93)90161-h · Cited by 1,966 · cited 1×
“It is proposed that long term nociceptive input from the OA joints in the lower limb may result in central sensitization in the spinal cord (Schaible et al., 1987; Woolf et al., 1988; Neugebauer and Schaible, 1990; Coderre et al., 1993).”
Nociception from skeletal muscle in relation to clinical muscle pain
Mense, S. (1993) · Pain · doi:10.1016/0304-3959(93)90027-m · Cited by 842
Synovial membrane inflammation and cytokine production in patients with early osteoarthritis.
Smith, M., Triantafillou, S., Parker, A., Youssef, P. P., & Coleman, M. (1997) · PubMed · Cited by 525
Sacroiliac Joint: Pain Referral Maps Upon Applying a New Injection/Arthrography Technique
Fortin, J. D., Dwyer, A. P., West, S., & Pier, J. (1994) · Spine · doi:10.1097/00007632-199407000-00010 · Cited by 436
Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients
Graven-Nielsen, T., Kendall, S. A., Henriksson, K. G., Bengtsson, M., Sörensen, J., Johnson, A., Gerdle, B., & Arendt-Nielsen, L. (2000) · Pain · doi:10.1016/s0304-3959(99)00308-5 · Cited by 416
Self-citationDickenson, A. H., Chapman, V., & Green, G. M. (1997) · General Pharmacology: The Vascular System · doi:10.1016/s0306-3623(96)00359-x · Cited by 399
Effects of an experimental arthritis on the sensory properties of fine articular afferent units
Schaible, H. G., & Schmidt, R. F. (1985) · Journal of Neurophysiology · doi:10.1152/jn.1985.54.5.1109 · Cited by 374
On the distribution of pain arising from deep somatic structures with charts of segmental pain areas
Kellgren, J. (1939) · Medical Entomology and Zoology · Cited by 354
Functional analysis of Group III afferent fibres of mammalian muscles
Paintal, A. S. (1960) · The Journal of Physiology · doi:10.1113/jphysiol.1960.sp006486 · Cited by 351
Cited by
Central sensitization: implications for the diagnosis and treatment of pain
Woolf, C. J. (2011) · Pain · doi:10.1016/j.pain.2010.09.030 · Cited by 4,771
The epidemiology and impact of pain in osteoarthritis
Neogi, T. (2013) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2013.03.018 · Cited by 1,730
Sensitization in patients with painful knee osteoarthritis
Arendt-Nielsen, L., Nie, H., Laursen, M. B., Laursen, B. S., Madeleine, P., Simonsen, O. H., & Graven-Nielsen, T. (2010) · Pain · doi:10.1016/j.pain.2010.04.003 · Cited by 990
Self-citationLee, Y. C., Nassikas, N. J., & Clauw, D. J. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3306 · Cited by 377
Osteoarthritis: the genesis of pain
Fu, K., Robbins, S. R., & McDougall, J. J. (2018) · Rheumatology · doi:10.1093/rheumatology/kex419 · Cited by 328
Metadata
- Authors
- Bajaj, P., Bajaj, P., Graven-Nielsen, T., & Arendt-Nielsen, L.
- Venue
- Pain
- Published
- 2001-08
- Volume
- 93
- Issue
- 2
- Pages
- 107-114
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2068735758
- Cited by
- 317
- References
- 39
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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