Cited by 434Pain Management and Placebo EffectPain Mechanisms and TreatmentsStatistical Methods in Clinical Trials

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A comparison of placebo effects in clinical analgesic trials versus studies of placebo analgesia

Vase, Lene, Riley, Joseph L., Price, Donald D.·2002·Pain

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Abstract

A previous meta-analysis of clinical analgesic trial studies showed generally low magnitudes of placebo analgesia (N. Engl. J. Med. 344 (2001) 1594). However, as studies included in their analysis used only placebo as a control condition, we conducted two meta-analyses, one in which 23 studies used only placebo as a control condition, and one in which 14 studies investigated placebo analgesic mechanisms. Magnitudes of placebo analgesic effects were much higher in the latter (mean effect size=0.95) as compared to the former (mean effect size=0.15) and were significantly different (P=0.003). This difference as well as differences in effect sizes within studies of placebo mechanisms may be parsimoniously explained by differences in expected pain levels produced by placebo suggestions and by conditioning. Furthermore, some of the studies of placebo analgesic mechanisms indicate that the magnitude of placebo analgesia is higher when the placebo analgesic effect is induced via suggestion combined with conditioning than via suggestion alone or conditioning alone. Based on these findings, we suggest that placebo analgesic effects are most optimally conceptualized in terms of perception of the placebo agent, and therefore a new definition of placebo response is proposed.

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THE POWERFUL PLACEBO
Beecher, H. K. (1955) · JAMA · doi:10.1001/jama.1955.02960340022006 · Cited by 1,850
Is the Placebo Powerless?
Hróbjartsson, A., & Gøtzsche, P. C. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105243442106 · Cited by 1,504
Foundations of clinical research application to practice
Portney, L. (1993) · Medical Entomology and Zoology · Cited by 1,135
THE MECHANISM OF PLACEBO ANALGESIA
Levine, J., Gordon, N., & Fields, H. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92762-9 · Cited by 1,094
Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific subsystems
Amanzio, M., & Benedetti, F. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00484.1999 · Cited by 899
An analysis of factors that contribute to the magnitude of placebo analgesia in an experimental paradigm
Price, D. D., Milling, L. S., Kirsch, I., Duff, A., Montgomery, G. H., & Nicholls, S. S. (1999) · Pain · doi:10.1016/s0304-3959(99)00081-0 · Cited by 569
Self-citation
TREATMENT OF EXCESSIVE AXILLARY SWEATING
Gibbs, J. R. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91979-5 · Cited by 560
Lidocaine patch: double-blind controlled study of a new treatment method for post-herpetic neuralgia
Rowbotham, M. C., Davies, P. S., Verkempinck, C., & Galer, B. S. (1996) · Pain · doi:10.1016/0304-3959(95)00146-8 · Cited by 525
Placebo Theory, Research , and Mechanisms
WHITE, L. E., Tursky, B., & SCHWARTZ, G. E. R. (1985) · Guilford Press eBooks · Cited by 485
Classical conditioning and the placebo effect
Montgomery, G. H., & Kirsch, I. (1997) · Pain · doi:10.1016/s0304-3959(97)00016-x · Cited by 468
Response expectancies in placebo analgesia and their clinical relevance
Pollo, A., Amanzio, M., Arslanian, A., Casadio, C., Maggi, G., & Benedetti, F. (2001) · Pain · doi:10.1016/s0304-3959(01)00296-2 · Cited by 442
A study of the placebo response
Lasagna, L. C., Mosteller, F. C., von Felsinger, J. M., & Beecher, H. K. (1954) · The American Journal of Medicine · doi:10.1016/0002-9343(54)90441-6 · Cited by 436
Response variability to analgesics: a role for non-specific activation of endogenous opioids
Amanzio, M., Pollo, A., Maggi, G., & Benedetti, F. (2001) · Pain · doi:10.1016/s0304-3959(00)00486-3 · Cited by 429
General practice consultations: is there any point in being positive?
Thomas, K. (1987) · BMJ · doi:10.1136/bmj.294.6581.1200 · Cited by 420
Randomised trial of oral morphine for chronic non-cancer pain
Moulin, D. E., Amireh, R., Sharpe, W. K. J., Boyd, D. B., Merskey, H., & Iezzi, A. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90339-6 · Cited by 390
The role of conditioning and verbal expectancy in the placebo response
Voudouris, N. J., Peck, C. L., & Coleman, G. (1990) · Pain · doi:10.1016/0304-3959(90)90057-k · Cited by 369
Somatotopic Activation of Opioid Systems by Target-Directed Expectations of Analgesia
Benedetti, F., Arduino, C., & Amanzio, M. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-09-03639.1999 · Cited by 350
Textbook of Pain
Rowlingson, J. C. (1990) · Anesthesiology · doi:10.1097/00000542-199003000-00045 · Cited by 341
Influence of the method of drug administration on analgesic response
Levine, J. D., & Gordon, N. C. (1984) · Nature · doi:10.1038/312755a0 · Cited by 324
CLINICIANS' EXPECTATIONS INFLUENCE PLACEBO ANALGESIA
Gracely, R. H., Dubner, R. A., Deeter, W. R., & Wolskee, P. J. (1985) · The Lancet · doi:10.1016/s0140-6736(85)90984-5 · Cited by 311
The opposite effects of the opiate antagonist naloxone and the cholecystokinin antagonist proglumide on placebo analgesia
Benedetti, F. (1996) · Pain · doi:10.1016/0304-3959(95)00179-4 · Cited by 297
Placebo and naloxone can alter post-surgical pain by separate mechanisms
Gracely, R. H., Dubner, R. A., Wolskee, P. J., & Deeter, W. R. (1983) · Nature · doi:10.1038/306264a0 · Cited by 263
Untitled work
(1996) · PubMed · Cited by 234
Partial antagonism of placebo analgesia by naloxone
Grevert, P., Albert, L. H., & Goldstein, A. (1983) · Pain · doi:10.1016/0304-3959(83)90203-8 · Cited by 228
Potentiation of placebo analgesia by proglumide
Benedetti, F., Amanzio, M., & Maggi, G. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92938-x · Cited by 217
Conditioned response models of placebo phenomena: further support
Voudouris, N. J., Peck, C. L., & Coleman, G. J. (1989) · Pain · doi:10.1016/0304-3959(89)90080-8 · Cited by 200
Effects of stress management on clinical outcomes in rheumatoid arthritis
Parker, J. C., Smarr, K. L., Buckelew, S. P., Stucky‐Ropp, R. C., Hewett, J. E., Johnson, J. C., Wright, G. E., Irvin, W. S., & Walker, S. E. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1780381214 · Cited by 181
Is there logic in the placebo?
Gøtzsche, P. C. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92273-x · Cited by 170
A Randomized, Placebo-Controlled Trial of Exercise Therapy in Patients with Acute Low Back Pain
Faas, A., Chavannes, A. W., van Eijk, J. T. M., & Gubbels, J. W. (1993) · Spine · doi:10.1097/00007632-199318110-00002 · Cited by 161
Control of Postoperative Pain by Transcutaneous Electrical Nerve Stimulation After Thoracic Operations
Benedetti, F., Amanzio, M., Casadio, C., Cavallo, A., Cianci, R., Giobbe, R., Mancuso, M., Ruffini, E., & Maggi, G. (1997) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(96)01249-0 · Cited by 160
Acupuncture for the management of primary dysmenorrhea
Helms, J. (1987) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(87)90381-x · Cited by 157
Mechanisms of Placebo Pain Reduction: An Empirical Investigation
Montgomery, G. H., & Kirsch, I. (1996) · Psychological Science · doi:10.1111/j.1467-9280.1996.tb00352.x · Cited by 156
An investigation of the placebo effect and age-related factors in the report of needle pain from venipuncture in children
Goodenough, B., Kampel, L., Champion, D. G., Laubreaux, L., Nicholas, K. M., Ziegler, B. J., & McInerney, M. (1997) · Pain · doi:10.1016/s0304-3959(97)00062-6 · Cited by 141
Conditioned placebo responses.
Voudouris, N. J., Peck, C. L., & Coleman, G. J. (1985) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.48.1.47 · Cited by 135
Conditioned placebo responses.
Voudouris, N. J., Peck, C. L., & Coleman, G. J. (1985) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.48.1.47 · Cited by 134
Reduction of postoperative pain and swelling by ultrasound treatment: a placebo effect
Hashish, I., Haia, H. K., Harvey, W., Feinmann, C., & Harris, M. (1988) · Pain · doi:10.1016/0304-3959(88)90289-8 · Cited by 128
Immediate Effects of Various Physical Medicine Modalities on Pain Threshold of an Active Myofascial Trigger Point
Hong, C., Yuan-chung, C., Pon, C. H., & Yu, J. Z. (1993) · Journal of Musculoskeletal Pain · doi:10.1300/j094v01n02_04 · Cited by 111
ANTI-INFLAMMATORY EFFECTS OF ULTRASOUND THERAPY: EVIDENCE FOR A MAJOR PLACEBO EFFECT
hashish, I. A., Harvey, W., & HARRIS, M. (1986) · Lara D. Veeken · doi:10.1093/rheumatology/25.1.77 · Cited by 108
Situational factors contributing to the placebo effect
Gryll, S. L., & Katahn, M. (1978) · Psychopharmacology · doi:10.1007/bf00426747 · Cited by 91
ANTICIPATION OF ANALGESIA, A PLACEBO EFFECT
LASKA, E. M., & Sunshine, A. N. (1973) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.1973.hed1301001.x · Cited by 89
TENS for children's procedural pain
Lander, J., & Fowler‐Kerry, S. (1993) · Pain · doi:10.1016/0304-3959(93)90133-a · Cited by 80
Norms, reliability, and item analysis of the hopelessness scale in general psychiatric, forensic psychiatric, and college populations
Durham, T. W. (1982) · Journal of Clinical Psychology · doi:10.1002/1097-4679(198207)38:3 · Cited by 78
Chiropractic adjustive manipulation on subjects with acute low back pain: visual analog pain scores and plasma beta-endorphin levels.
Sanders, G. E., Reinert, O. C., Tepe, R., & Maloney, P. (1990) · PubMed · Cited by 75
Increased Stress and Effectiveness of Placebos and "Active" Drugs
Beecher, H. K. (1960) · Science · doi:10.1126/science.132.3419.91 · Cited by 72
Effect of TENS on Pain, Medications, and Pulmonary Function Following Coronary Artery Bypass Graft Surgery
Forster, E. L., Kramer, J. F., Lucy, S. D., Scudds, R. A., & Novick, R. J. (1994) · CHEST Journal · doi:10.1378/chest.106.5.1343 · Cited by 69
A placebo controlled double blind trial to evaluate the effectiveness of pulsed short wave therapy for osteoarthritic hip and knee pain
Moffett, J. A. K., Richardson, P. H., Frost, H., & Osborn, A. (1996) · Pain · doi:10.1016/0304-3959(96)03100-4 · Cited by 65
Assessing placebo effects without placebo groups: an untapped possibility?
Price, D. D. (2001) · Pain · doi:10.1016/s0304-3959(01)00265-2 · Cited by 62
Self-citation
Prophylactic penicillin: Effect on posttreatment symptoms following root canal treatment of asymptomatic periapical pathosis
Walton, R. E., & Chiappinelli, J. (1993) · Journal of Endodontics · doi:10.1016/s0099-2399(06)80535-2 · Cited by 60
Explication and Implications of the Placebo Concept
Grünbaum, A. (1984) · Boston studies in the philosophy of science · doi:10.1007/978-94-009-6254-5_8 · Cited by 58
Biology of placebo analgesia
Fields, H. L., & Levine, J. D. (1981) · The American Journal of Medicine · doi:10.1016/0002-9343(81)90525-8 · Cited by 52
Use of Transcutaneous Electrical Nerve Stimulation For Postoperative Pain
HARGREAVES, A., & Lander, J. (1989) · Nursing Research · doi:10.1097/00006199-198905000-00014 · Cited by 51
Expectations of analgesia do not affect spinal nociceptive R-III reflex activity: an experimental study into the mechanism of placebo-induced analgesia
Roelofs, J., ter Riet, G., Peters, M. L., Kessels, A. G. H., Reulen, J. P. H., & Menheere, P. P. C. A. (2000) · Pain · doi:10.1016/s0304-3959(00)00347-x · Cited by 35
Transcutaneous electrical nerve stimulation following appendicectomy: the placebo effect.
Conn, I. G., Marshall, A. H., Yadav, S., Daly, J. C., & Jaffer, M. (1986) · PubMed Central · Cited by 34
Influence of Sensory Suggestibility on Treatment Outcome in Headache Patients
Classen, W., Feingold, E., & Netter, P. (2008) · Neuropsychobiology · doi:10.1159/000117982 · Cited by 25
Acute pain in a clinical setting: Effects of cognitive-behavioural skills training
Tan, S., & Poser, E. G. (1982) · Behaviour Research and Therapy · doi:10.1016/0005-7967(82)90031-6 · Cited by 22
Prevention of Breast Pain and Milk Secretion with Bromocriptine After Second‐Trimester Abortion
Andersen, A. N., Damm, P., Tabor, A., Pedersen, I. M., & Harring, M. (1990) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016349009028686 · Cited by 12
Wirksamkeit der Akupunktur bei Patienten mit generalisierter Tendomyopathie (Fibromyalgie)
Sprott, H., Mennet, P., Stratz, T., & Müller, W. D. (1993) · Aktuelle Rheumatologie · doi:10.1055/s-2008-1047326 · Cited by 10
Pain evaluation during carbon dioxide laser vaporization for cervical intraepithelial neoplasia: a randomized trial.
Frega, A., Stentella, P., Di Renzi, F., Gallo, G., Palazzetti, P. L., Vescovo, M. D., Ciccarone, M., & Pachı̀, A. (1994) · PubMed · Cited by 9
Lars Ole Andersen, Mogens H Claësson, Asbjørn Hróbjartsson and Anja Norbæk Sørensen, Placebo. Historie, biologi og effekt, Akademisk Forlag, 1997, pp. 178, illus. (87-500-3413-8).
Hardy, A. (1999) · Medical History · doi:10.1017/s0025727300065224 · Cited by 2
Acute Pain in a Clinical Setting: Effects of Cognitive-Behavioral Skills Training
Tan, S.-Y. (1980) · eScholarship@McGill (McGill) · doi:10.82308/6191 · Cited by 2

Research works printed but not linked: 3

Chenard, 1991, Evaluation dun traitement comportmental de la lombalgie chronique: lecole interactionelle du dos., Sci Comportement, 21, 225
Coyne, 1995, Transcutaneous electrical nerve stimulator for procedural pain associated with intravenous needle stics., J Intraven Nurs, 18, 263
Wojciechowski, 1984, Behavioral treatment of tension headache: a contribution to controlled outcome research methodology., Gedrag Tijdschrift Voor Psychol, 12, 16

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Self-citation
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Biological, clinical, and ethical advances of placebo effects
Finniss, D. G., Kaptchuk, T. J., Miller, F. G., & Benedetti, F. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61706-2 · Cited by 1,309
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Authors: Vase, L., Riley, J. L., & Price, D. D.
Affiliations: Aarhus University (DK)
University of Florida Health (US)
Corresponding author: Price, Donald D.
ORCID: Vase, Lene
Riley, Joseph L.
Price, Donald D.
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2002-10
Volume: 99
Issue: 3
Pages: 443-452
ISSN: 0304-3959 (ISSN-L)
DOI: 10.1016/s0304-3959(02)00205-1
OpenAlex: W1966127473
Cited by: 434
References: 60
Citations by year: 2026: 5 · 2025: 18 · 2024: 13 · 2023: 13 · 2022: 16 · 2021: 18 · 2020: 18 · 2019: 22 · 2018: 19 · 2017: 14 · 2016: 22 · 2015: 15 · 2014: 28 · 2013: 21 · 2012: 14
FWCI: 6.85
Type: journal article
Language: en
Open access: closed
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
Keywords: placebo analgesia, placebo response
MeSH terms: Analgesia, Clinical Trials as Topic, Humans, Pain Measurement, Placebo Effect

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A comparison of placebo effects in clinical analgesic trials versus studies of placebo analgesia

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