Adrenaline-mediated glycogen phosphorylase activation is enhanced in rat soleus muscle with increased glycogen content
Abstract
The effect of glycogen content on the activation of glycogen phosphorylase during adrenaline stimulation was investigated in soleus muscles from Wistar rats. Furthermore, adrenergic activation of glycogen phosphorylase in the slow-twitch oxidative soleus muscle was compared to the fast-twitch glycolytic epitrochlearis muscle. The glycogen content was 96.4 +/- 4.4 mmol (kg dw)(-1) in soleus muscles. Three hours of incubation with 10 mU/ml of insulin (and 5.5 mM glucose) increased the glycogen content to 182.2+/-5.9 mmol (kg dw)(-1) which is similar to that of epitrochlearis muscles (175.7+/-6.9 mmol (kg dw)(-1)). Total phosphorylase activity in soleus was independent of glycogen content. Adrenaline (10(-6) M) transformed about 20% and 35% (P < 0.01) of glycogen phosphorylase to the a form in soleus with normal and high glycogen content, respectively. In epitrochlearis, adrenaline stimulation transformed about 80% of glycogen phosphorylase to the a form. Glycogen synthase activation was reduced to low level in soleus muscles with both normal and high glycogen content. In conclusion, adrenaline-mediated glycogen phosphorylase activation is enhanced in rat soleus muscles with increased glycogen content. Glycogen phosphorylase activation during adrenaline stimulation was much higher in epitrochlearis than in soleus muscles with a similar content of glycogen.
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The glycogen concentration in muscles from dexamethasone-treated rats was not above the content found in non-fasted rats.
“The glycogen concentration in muscles from dexamethasone-treated rats was, however, not above the content found in non-fasted rats, in which insulin activates glycogen synthase [38].”
In non-fasted rats, insulin activates glycogen synthase.
“in which insulin activates glycogen synthase [38].”
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Rasmushaugen, A. (2009) · NORA - Norwegian Open Research Archives
- Authors
- Jensen, J., Aslesen, R., Jebens, E., & Skrondal, A.
- Affiliations
- National Institute of Occupational Health (NO)
- University of Oslo (NO)
- Norwegian Institute of Public Health (NO)
- Corresponding author
- Jensen, Jørgen
- Venue
- Biochimica et Biophysica Acta (BBA) - General Subjects
- Publisher
- Elsevier BV
- Published
- 1999-10
- Volume
- 1472
- Issue
- 1-2
- Pages
- 215-222
- ISSN
- 0304-4165 (ISSN-L)
- OpenAlex
- W1982121582
- Cited by
- 24
- References
- 37
- Citations by year
- 2024: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2014: 2 · 2013: 1
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Rheumatology › Glycogen Storage Diseases and Myoclonus
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- glycogen phosphorylase, epinephrine, soleus muscle, epitrochlearis muscle, glycogen content, slow-twitch muscle, fast-twitch muscle, glycogen synthase, insulin, muscle glycogen metabolism
- MeSH terms
- Animals, Enzyme Activation, Epinephrine, Glycogen, Phosphorylases, Male, Rats, Wistar, Muscle, Skeletal, Rats, In Vitro Techniques
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