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Cited by 39Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and LipoproteinsAdipose Tissue and Metabolism

Improved insulin-stimulated glucose uptake and glycogen synthase activation in rat skeletal muscles after adrenaline infusion: role of glycogen content and pkb phosphorylation

Jensen, J., Ruzzin, J., Jebens, E., Brennesvik, E. O., Knardahl, S.·2005·Acta Physiologica Scandinavica
DOI 10.1111/j.1365-201x.2005.01437.x
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Abstract

AIM: Effects of in vivo adrenaline infusion on subsequent insulin-stimulated glucose uptake and glycogen synthase activation was investigated in slow-twitch (soleus) and fast-twitch (epitrochlearis) muscles. Furthermore, role of glycogen content and Protein kinase B (PKB) phosphorylation for modulation insulin sensitivity was investigated. METHODS: Male Wistar rats received adrenaline from osmotic mini pumps ( approximately 150 microg kg(-1) h(-1)) for 1 or 12 days before muscles were removed for in vitro studies. RESULTS: Glucose uptake at physiological insulin concentration was elevated in both muscles after 1 and 12 days of adrenaline infusion. Insulin-stimulated glycogen synthase activation was also improved in both muscles. This elevated insulin sensitivity occurred despite the muscles were exposed to hyperglycaemia in vivo. After 1 day of adrenaline infusion, glycogen content was reduced in both muscles; insulin-stimulated PKB ser(473) phosphorylation was increased in both muscles only at the highest insulin concentration. After 12 days of adrenaline infusion, glycogen remained low in epitrochlearis, but returned to normal level in soleus; insulin-stimulated PKB phosphorylation was normal in both muscles. CONCLUSION: Insulin-stimulated glucose uptake and glycogen synthase activation were increased after adrenaline infusion. Increased insulin-stimulated glucose uptake and glycogen synthase activation after adrenaline infusion cannot be explained by a reduction in glycogen content or an increase in PKB phosphorylation. The mechanisms for the improved insulin sensitivity after adrenaline treatment deserve particular attention as they occur in conjunction with hyperglycaemia.

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Crossref · 10.1111/j.1365-201x.2005.01437.x

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  • Chronic epinephrine infusion enhanced glycogen synthesis activation and insulin-dependent glucose uptake in rat skeletal muscles.

    “Chronic epinephrine infusion enhanced glycogen synthesis activation and insulin-dependent glucose uptake in rat skeletal muscles (33).”

    From The progression of secondary diabetes: A review of modeling studies (2022) · cites this paper as [33]

  • Long period effect of low-dose epinephrine can reduce blood glucose level in vivo.

    “the updated biological findings indicate that the long period effect of low-dose epinephrine can improve insulin sensitivity and reduce blood glucose level in vivo (31–33).”

    From The progression of secondary diabetes: A review of modeling studies (2022) · cites this paper as [33]

  • Long period effect of low-dose epinephrine can improve insulin sensitivity in vivo.

    “the updated biological findings indicate that the long period effect of low-dose epinephrine can improve insulin sensitivity and reduce blood glucose level in vivo (31–33).”

    From The progression of secondary diabetes: A review of modeling studies (2022) · cites this paper as [33]

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Authors
Jensen, J., Ruzzin, J., Jebens, E., Brennesvik, E. O., & Knardahl, S.
Affiliations
National Institute of Occupational Health (NO)
Corresponding author
Jensen, J.
ORCID
Venue
Acta Physiologica Scandinavica
Publisher
Wiley
Published
2005-05-23
Volume
184
Issue
2
Pages
121-130
ISSN
  • 0001-6772 (ISSN-L)
  • 1365-201X
DOI
10.1111/j.1365-201x.2005.01437.x
OpenAlex
W2022612296
Cited by
39
References
45
Citations by year
2026: 1 · 2023: 1 · 2022: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 2 · 2013: 1 · 2012: 3
FWCI
1.25
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Acta Physiologica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
adrenaline infusion, insulin sensitivity, insulin-stimulated glucose uptake, glycogen synthase activation, Akt phosphorylation, skeletal muscle, soleus muscle, epitrochlearis muscle, glycogen content, hyperglycemia, slow-twitch muscle, fast-twitch muscle
MeSH terms
Animals, Blood Glucose, Body Weight, Epinephrine, Glucose, Glycogen, Glycogen Synthase, Infusions, Intravenous, Insulin, Lactates, Male, Norepinephrine, Phosphorylation, Proto-Oncogene Proteins, Receptors, Adrenergic, beta, Rats, Wistar, Protein Serine-Threonine Kinases, Muscle, Skeletal, Proto-Oncogene Proteins c-akt, Rats

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