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The fragile x mental retardation protein binds and regulates a novel class of mRNAs containing u rich target sequences
Abstract
Fragile X syndrome is a common form of inherited mental retardation caused by the absence of the fragile X mental retardation protein (FMRP). It has been hypothesized that FMRP is involved in the processing and/or translation of mRNAs. Human and mouse target-mRNAs, containing purine quartets, have previously been identified. By using cDNA-SELEX (systematic evolution of ligands by exponential enrichment), we identified another class of human target-mRNAs which contain U rich sequences. This technique, in contrast to oligonucleotide-based SELEX, allows the identification of FMRP targets directly from mRNA pools. Many of the proteins encoded by the identified FMRP targets have been implicated in neuroplasticity. Steady state levels of target-mRNAs were unchanged in the brain of fragile X mice. However, levels of two target-encoded proteins, an L-type calcium channel subunit and MAP1B, were downregulated in specific brain regions suggesting a defect in the expression of target-encoded proteins in fragile X syndrome.
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“FMRP regulates stability, subcellular transport, and translation of neuronal mRNAs encoding for proteins involved the in synaptic structure and function (58,(65)(66)(67).”
From Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics (2012) · cites this paper as [66]
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Metadata
- Authors
- Chen, L., Yun, S.-W., Seto, J., Liu, W., & Toth, M.
- Affiliations
- Cornell University (US)
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 120
- Issue
- 4
- Pages
- 1005-1017
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2038651628
- Cited by
- 160
- References
- 40
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 8 · 2020: 7 · 2019: 3 · 2018: 6 · 2017: 11 · 2016: 8 · 2015: 7 · 2014: 12 · 2013: 5 · 2012: 13
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns034151-06)
- National Institute of Neurological Disorders and Stroke (R01NS34151)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- fragile X syndrome, FMRP, mRNA binding, U-rich sequences, MAP1B, neuroplasticity, brain gene expression
- MeSH terms
- Adenosine Triphosphatases, Animals, Bacteria, Base Sequence, Brain, Cell Line, Clathrin, Dose-Response Relationship, Drug, Embryo, Mammalian, Embryo, Nonmammalian, Fetus, Humans, Insecta, Kidney, Microtubule-Associated Proteins, Molecular Sequence Data, Mucins, Nerve Tissue Proteins, Oligopeptides, Peptides, Phosphopyruvate Hydratase, Protein Binding, RNA, Messenger, Uridine, Blotting, Western, RNA-Binding Proteins, Sequence Homology, Amino Acid, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, Guanine Nucleotide Dissociation Inhibitors, rhoA GTP-Binding Protein, Electrophoretic Mobility Shift Assay, RNA-Binding Protein FUS, Mice, Fragile X Messenger Ribonucleoprotein 1, Fragile X Mental Retardation Protein, In Vitro Techniques
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