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Cited by 174Estrogen and related hormone effectsNeuroendocrine regulation and behaviorNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

The human forebrain has discrete estrogen receptor α messenger RNA expression: high levels in the amygdaloid complex

Österlund, M.K, Keller, E, Hurd, Y.L·1999·Neuroscience
DOI 10.1016/s0306-4522(99)00443-1
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Abstract

Estrogen is considered to play an important role in neuropsychiatric disorders and the estrogen receptors mediate the action of the hormone. In the present study, the messenger RNA expression pattern of the estrogen receptor alpha subtype was identified in the post mortem human brain. High stringent in situ hybridization histochemistry was performed using a riboprobe specific for the estrogen receptor alpha subtype. The human brain was mainly characterized by abundant estrogen receptor alpha messenger RNA expression in the amygdala and hypothalamus, but labeling (lower) was also found in the extended sublenticular amygdala, cerebral cortex, and hippocampus. In the amygdala, the estrogen receptor alpha messenger RNA was preferentially expressed in medially-localized nuclei suggesting that estrogen regulates distinct human amygdala-mediated functions. The Cynomologous monkey brain was also examined in the present study and a similar distribution of the estrogen receptor alpha messenger RNA signal was observed in the human and monkey brain. However, the primate expression pattern differed in part from the known distribution in the rat. The current results show that estrogen receptor alpha messenger RNA is expressed in discrete areas of the human brain not only related to neuroendocrine function, but also emotion, memory, and cognition, which is consistent with the hypothesized involvement of estrogen in schizophrenia, affective disorders, and Alzheimers disease.

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Research works printed but not linked: 3

  1. Gloor P. (1997) The amygdaloid system. In The Temporal Lobe and Limbic System (ed. Gloor P.), pp. 591–651. Oxford University Press, Inc., New York.
  2. Narabayashi H. and Shima F. (1973) Which is the better amygdala target, the medial or lateral nucleus for behavioral problems and paroxysms in epileptics. In Surgical Approaches in Psychiatry (eds Laitinen L. V. and Livingston K. E.), pp. 129–134. University Park Press, Baltimore.
  3. Smith S. S. (1994) Hormones, mood and neurobiology—a summary. In The Modern Management of the Menopause. A Perspective for the 21st Century (eds Berg G. and Hammar M.), pp. 257–267. The Parthenon Publishing Group, London.

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Metadata

Authors
Österlund, M. K., Keller, E., & Hurd, Y. L.
Affiliations
Karolinska Institutet (SE)
Corresponding author
Hurd, Y.L
ORCID
Hurd, Y.L
Venue
Neuroscience
Publisher
Elsevier BV
Published
1999-12
Volume
95
Issue
2
Pages
333-342
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/s0306-4522(99)00443-1
OpenAlex
W2052883666
Cited by
174
References
47
Citations by year
2026: 4 · 2025: 5 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 7 · 2018: 17 · 2017: 3 · 2016: 12 · 2015: 7 · 2014: 8 · 2013: 3 · 2012: 12
FWCI
2.64
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
estrogen receptor alpha, mRNA expression, human brain, amygdala, hypothalamus, extended amygdala, cerebral cortex, hippocampus, estrogen, emotions, memory, cognition, schizophrenia, mood disorders, Alzheimer's disease, in situ hybridization
MeSH terms
Adolescent, Adult, Aged, Amygdala, Animals, Haplorhini, Female, Humans, Hypothalamus, Male, Middle Aged, Receptors, Estrogen, RNA, Messenger, Species Specificity, Gene Expression, In Situ Hybridization, Rats

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