The lateral amygdaloid nucleus: sensory interface of the amygdala in fear conditioning
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Previous work has implicated projections from the acoustic thalamus to the amygdala in the classical conditioning of emotional responses to auditory stimuli. The purpose of the present studies was to determine whether the lateral amygdaloid nucleus (AL), which is a major subcortical target of projections from the acoustic thalamus, might be the sensory interface of the amygdala in emotional conditioning. Lesions were placed in AL of rats and the effects on emotional conditioning were examined. Lesions of AL, but not lesions of the striatum above or the cortex adjacent to the AL, interfered with emotional conditioning. Lesions that only partially destroyed AL or lesions placed too ventrally that completely missed AL had no effect. AL lesions did not affect the responses elicited following nonassociative (random) training. AL is thus an essential link in the circuitry through which auditory stimuli are endowed with affective properties and may function as the sensory interface of the amygdala during emotional learning.
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Even rats do many things within a single emotion category: in the face of threat, they can freeze, flee, or engage in defensive treading.
“Even rats do many things within a single emotion category: in the face of a threat, rats can freeze (e.g., LeDoux et al. 1990), flee (Vazdarjanova & McGaugh 1998), or engage in “defensive treading,” in which they kick bedding in the direction of a known threat (Reynolds & Berridge 2002; 2003; 2008).”
From The brain basis of emotion: a meta-analytic review (2012) · cites this paper as LeDoux et al. 1990
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- Authors
- LeDoux, J., Cicchetti, P., Xagoraris, A., & Romanski, L.
- Affiliations
- New York University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1990-04-01
- Volume
- 10
- Issue
- 4
- Pages
- 1062-1069
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6570227
- OpenAlex
- W2123717940
- Cited by
- 1,167
- References
- 2
- Citations by year
- 2026: 17 · 2025: 20 · 2024: 29 · 2023: 21 · 2022: 33 · 2021: 28 · 2020: 29 · 2019: 25 · 2018: 30 · 2017: 28 · 2016: 31 · 2015: 37 · 2014: 30 · 2013: 44 · 2012: 49
- FWCI
- 14.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Institute of Mental Health (MH38774)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- fear conditioning, auditory fear conditioning, amygdala, emotional learning, sensory interfaces, lesion studies, rats, striatum, auditory stimuli
- MeSH terms
- Acoustic Stimulation, Affect, Amygdala, Animals, Behavior, Animal, Conditioning, Classical, Electric Stimulation, Fear, Male, Rats, Inbred Strains, Sensation, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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