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Cited by 67Stress Responses and CortisolHormonal and reproductive studiesPosttraumatic Stress Disorder Research

Cerebrospinal fluid and plasma testosterone levels in post-traumatic stress disorder and tobacco dependence

Mulchahey, J.Jeffrey, Ekhator, Nosa N., Zhang, Hong, Kasckow, John W., Baker, Dewleen G., Geracioti, Thomas D.·2001·Psychoneuroendocrinology
DOI 10.1016/s0306-4530(00)00052-4
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Abstract

Background Little is known about the relationship between endogenous central nervous system (CNS) testosterone and any psychiatric syndrome. The goal of this study was to screen for potential abnormalities in CNS testosterone levels in patients with post-traumatic stress disorder (PTSD) and/or tobacco dependence.Methods We sampled cerebrospinal fluid (CSF) via a subarachnoid catheter over six hours and determined hourly basal CSF concentrations of testosterone in 11 combat veterans with PTSD and 12 normal volunteers. Smokers were abstinent for 11-17 h. Testosterone in CSF and matching plasma samples was assayed by radioimmunoassay.Results A factor analysis for effects of PTSD status, smoking status and sample time revealed significant effects of PTSD or smoking status, but not time, on CSF testosterone. CSF testosterone levels were lower in individuals with PTSD as compared with normal volunteers. When divided by smoking status, abstinent smokers had mean CSF testosterone levels higher than those of non-smokers. A similar analysis of plasma testosterone revealed no significant effects of any factor on plasma testosterone.Conclusions These results indicate that CSF testosterone is significantly influenced by PTSD and smoking status. The exposure of the brain to altered levels of testosterone in smokers and patients with PTSD may have pathophysiologic significance in these conditions.

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  • Lower circulating testosterone levels are often found in individuals with PTSD or MDD.

    “lower circulating levels are often found in individuals with PTSD or MDD16, 17.”

    From Neurobiology of resilience (2012) · cites this paper as [16]

  • Testosterone in males promotes resilience in major depressive disorder and post-traumatic stress disorder.

    “there is evidence that testosterone in males promotes resilience in MDD and PTSD”

    From Neurobiology of resilience (2012) · cites this paper as [16]

  • Epidemiological data show that women are significantly more vulnerable to developing major depressive disorder and post-traumatic stress disorder than men.

    “epidemiological data showing that woman are significantly more vulnerable to developing these disorders than men 16, 17”

    From Neurobiology of resilience (2012) · cites this paper as [16]

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Authors
Mulchahey, J. J., Ekhator, N. N., Zhang, H., Kasckow, J. W., Baker, D. G., & Geracioti, T. D.
Affiliations
Cincinnati VA Medical Center (US)
Corresponding author
Mulchahey, J.Jeffrey
ORCID
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
2001-04
Volume
26
Issue
3
Pages
273-285
ISSN
0306-4530 (ISSN-L)
DOI
10.1016/s0306-4530(00)00052-4
OpenAlex
W2148752357
Cited by
67
References
30
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 1 · 2017: 4 · 2016: 6 · 2015: 5 · 2014: 4 · 2013: 2 · 2012: 4
FWCI
1.23
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
U.S. Department of Veterans Affairs
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Keywords
post-traumatic stress disorder, tobacco dependence, plasma testosterone, combat veterans, smoking, sex hormones
MeSH terms
Adult, Female, Humans, Male, Psychiatric Status Rating Scales, Smoking, Stress Disorders, Post-Traumatic, Testosterone, Tobacco Use Disorder

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