CoChat
Sign Up
Cited by 8Smoking Behavior and CessationHormonal and reproductive studiesAdrenal Hormones and Disorders

Relationship of smoking cessation and nicotine gum use to salivary androstenedione and testosterone in middle-aged men

Istvan, Joseph A., Buist, A.Sonia, Hess, David L., Voelker, Helen·1995·Metabolism
DOI 10.1016/0026-0495(95)90294-5
Open this paper in CoChat — free account

Abstract

Cross-sectional studies have associated cigarette smoking in men with elevated androstenedione and little net effect on other sex steroids. However, it is not clear if such findings reflect the impact of nicotine exposure or if sex hormone levels change following smoking cessation. The relationship of the reported number of cigarettes smoked per day and salivary cotinine to salivary testosterone and androstenedione was examined in 221 men aged 35 to 59 years at baseline and 1 year following randomization into a clinical trial including a smoking-cessation intervention. At baseline, salivary cotinine was related to increased salivary androstenedione and testosterone following control for age, body mass, alcohol intake, and time of day of specimen collection (partial r = +.14 and +.30 P < .05 and .01, respectively). The reported number of cigarettes smoked per day was unrelated to either hormone. At the first annual visit, there was a significant decrease in the salivary androstenedione of men who had quite smoking and were currently using nicotine gum (94 v 60 pg/mL, P < .05, n = 34) and of men who had quit smoking and were not exposed to nicotine (86 v 56 pg/mL, P < .05, n = 48), whereas the salivary androstenedione of men who remained smokers at the first annual visit was unchanged (83 v 85 pg/mL, n = 139). Salivary testosterone levels were not significantly affected by a change in smoking status.(ABSTRACT TRUNCATED AT 250 WORDS)

Integrity signals

Registry

Crossref · 10.1016/0026-0495(95)90294-5

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Istvan, J. A., Buist, A. S., Hess, D. L., & Voelker, H.
Affiliations
University of Minnesota (US)
Corresponding author
Istvan, Joseph A.
ORCID
Hess, David L.
Venue
Metabolism
Publisher
Elsevier BV
Published
1995-01
Volume
44
Issue
1
Pages
90-95
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/0026-0495(95)90294-5
OpenAlex
W2037672992
Semantic Scholar
fc01594da3789f2e14180e712758044f11ed0e6e
Cited by
8
References
39
Citations by year
2022: 1 · 2015: 1 · 2013: 1
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1t32mh019373-01, 5r29hl038414-05)
  • National Heart, Lung, and Blood Institute (HL 38414)
  • National Institute of Mental Health (MH19373)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 18185)
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
smoking cessation, nicotine gum, salivary testosterone, sex steroids, salivary cotinine, cigarette smoking, middle-aged men, nicotine exposure, smoking cessation interventions
MeSH terms
Adult, Chewing Gum, Cross-Sectional Studies, Humans, Male, Middle Aged, Nicotine, Saliva, Smoking, Testosterone, Smoking Cessation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review