Cited by 152Neurotransmitter Receptor Influence on BehaviorHypothalamic control of reproductive hormonesSexual Differentiation and Disorders

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Pubertal changes in gonadal hormones do not underlie adolescent dopamine receptor overproduction

Andersen, S·2002·Psychoneuroendocrinology

DOI 10.1016/s0306-4530(01)00069-5

Open this paper in CoChat — free account

Abstract

Males, but not females, overproduce dopamine receptors in the striatum of rats across the periadolescent period followed by their elimination during young adulthood. In order to investigate the role that gonadal hormones play in this pubertal process, rats were castrated or ovariectomized at postnatal day (P) 28 when estrogen and testosterone levels are beginning to surge. Dopamine D1 and D2 striatal receptor density was then determined with autoradiography at P40 (adolescence) and P80 (young adulthood) to determine if either testosterone stimulates the overproduction of receptors in males or if estrogen inhibits this process in females. Neither castration nor ovariectomy altered dopamine receptor density, although enhanced testosterone levels increased D1 receptor binding 4.2% and 19.5% in males and females, respectively. The results of this study suggest that the endogenous rise in gonadal steroid hormones during puberty is not responsible for the overproduction of receptors in males or the lack of overproduction in females.

Integrity signals

Registry

Crossref · 10.1016/s0306-4530(01)00069-5

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Psychopharmacology: The Fourth Generation of Progress
Bloom, F. E., & Kupfer, D. J. (1995) · Medical Entomology and Zoology · Cited by 2,985
Synaptic density in human frontal cortex —Developmental changes and effects of aging
Peter R., H. (1979) · Brain Research · doi:10.1016/0006-8993(79)90349-4 · Cited by 2,645
Schizophrenia: Caused by a fault in programmed synaptic elimination during adolescence?
Feinberg, I. (1982) · Journal of Psychiatric Research · doi:10.1016/0022-3956(82)90038-3 · Cited by 1,395
Concurrent overproduction of synapses in diverse regions of the primate cerebral cortex
Rakic, P., Bourgeois, J.-P., Eckenhoff, M. F., Zecevic, N., & Goldman-Rakic, P. S. (1986) · Science · doi:10.1126/science.3952506 · Cited by 1,133 · cited 1×
“, 1987) and primates (Lidow et al., 1991; Rakic et al., 1986; Rosenberg and Lewis, 1995) as well.”
Estimnates of the Prevalence of Childhood Maladjustment in a Community Survey in Puerto Rico
Bird, H. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800360068010 · Cited by 716
Is schizophrenia due to excessive synaptic pruning in the prefrontal cortex? The Feinberg hypothesis revisited
Keshavan, M. S., Anderson, S., & Pettergrew, J. W. (1994) · Journal of Psychiatric Research · doi:10.1016/0022-3956(94)90009-4 · Cited by 525
Evidence for dopamine receptor pruning between adolescence and adulthood in striatum but not nucleus accumbens
Teicher, M. H., Andersen, S. L., & Hostetter, J. C. (1995) · Developmental Brain Research · doi:10.1016/0165-3806(95)00109-q · Cited by 505
Self-citation
The Role of Estrogens in Schizophrenia Gender Differences
Seeman, M. V., & Lang, M. (1990) · Schizophrenia Bulletin · doi:10.1093/schbul/16.2.185 · Cited by 425
Human brain dopamine receptors in children and aging adults
Seeman, P., Bzowej, N. H., Guan, H. ‐., Bergeron, C., Becker, L. E., Reynolds, G. P., Bird, E. D., Riederer, P., Jellinger, K., Watanabe, S., et al. (1987) · Synapse · doi:10.1002/syn.890010503 · Cited by 404
Sex differences in dopamine receptors and their relevance to ADHD
Andersen, S. L., & Teicher, M. H. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00044-5 · Cited by 353
Self-citation

Show all 27 references

Sorted by citations

Items 101–151 of 151

Gonadal hormones-mediated effects on the stimulation of dopamine turnover in mesolimbic and nigrostriatal systems by cocaine- and amphetamine-regulated transcript (CART) peptide in male rats
Yang, S.-C., & Shieh, K. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.08.007 · Cited by 17
Age dependence of pilocarpine-induced status epilepticus and inhibition of CaM kinase II activity in the rat.
Singleton, M. W., Holbert, W. H., Ryan, M., Lee, A. T., Kurz, J., & Churn, S. B. (2005) · Brain research. Developmental brain research · doi:10.1016/j.devbrainres.2005.02.001 · Cited by 20
Age- and sex-dependent nicotine pretreatment effects on the enhancement of methamphetamine self-administration in Sprague-Dawley rats
Cardenas, A., & Lotfipour, S. (2022) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntab218 · Cited by 16
Sex‐specific association between infant caudate volumes and a polygenic risk score for major depressive disorder
Acosta, H., Kantojärvi, K., Tuulari, J. J., Lewis, J. D., Hashempour, N., Scheinin, N. M., Lehtola, S. J., Fonov, V., Collins, D. L., Evans, A. C., et al. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24722 · Cited by 17
Immune signaling as a node of interaction between systems that sex-specifically develop during puberty and adolescence
Granata, L., Gildawie, K. R., Ismail, N., Brenhouse, H. C., & Kopec, A. M. (2022) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2022.101143 · Cited by 15
Sexually dimorphic postural adjustments during vertical behaviour are altered in a unilateral 6-OHDA rat model of Parkinson's disease
Field, E. F., Metz, G. A. S., Pellis, S. M., & Whishaw, I. Q. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.004 · Cited by 15
The Role of Dopamine D1 and D2 Receptors in Adolescent Methylphenidate Conditioned Place Preference: Sex Differences and Brain-Derived Neurotrophic Factor
Cummins, E. D., Griffin, S. B., Duty, C. M., Peterson, D. J., Burgess, K. C., & Brown, R. W. (2014) · Developmental Neuroscience · doi:10.1159/000360636 · Cited by 14
Differences in vulnerability to nicotine-induced kindling between female and male periadolescent rats
Gomes, P. X. L., de Oliveira, G. V., de Araújo, F. Y. R., Viana, G. S. D. B., de Sousa, F. C. F., Hyphantis, T. N., Grunberg, N. E., Carvalho, A. F., & Macêdo, D. S. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2799-5 · Cited by 12
Preventative treatment in an animal model of ADHD: Behavioral and biochemical effects of methylphenidate and its interactions with ovarian hormones in female rats
Lukkes, J. L., Freund, N., Thompson, B. S., Meda, S., & Andersen, S. L. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.06.003 · Cited by 11
Self-citation
Sex- and Genotype-Dependent Nicotine-Induced Behaviors in Adolescent Rats with a Human Polymorphism (rs2304297) in the 3′-UTR of the CHRNA6 Gene
Cardenas, A. M., Bai, Y., Heydary, Y. H., Li, J., Leslie, F. M., & Lotfipour, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063145 · Cited by 12
Adolescence and Postpartum: Two Life Periods to Deepen Our Understanding of the Complexity of Female Rat Sexual Behavior
Agrati, D. (2022) · Sexes · doi:10.3390/sexes3020022 · Cited by 10
The effects of paradoxical sleep deprivation on amphetamine-induced behavioral sensitization in adult and adolescent mice
Kameda, S. R., Fukushiro, D. F., Trombin, T. F., Sanday, L., Wuo‐Silva, R., Saito, L. P., Tufik, S., D’Almeida, V., & Frussa‐Filho, R. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.04.046 · Cited by 9
The sex difference of plasma homovanillic acid is unaffected by cross-sex hormone administration in transsexual subjects
Giltay, E. J., Kho, K. H., Blansjaar, B. A., Verbeek, M. M., Geurtz, P. B. H., Geleijnse, J. M., & Gooren, L. J. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.06307 · Cited by 9
Langfristige Folgen des chronischen Cannabiskonsums
Schneider, M. (2004) · SUCHT - Zeitschrift für Wissenschaft und Praxis / Journal of Addiction Research and Practice · doi:10.1024/2004.05.04 · Cited by 8
Stress and the Developing Brain
Wright, L., & Perrot, T. S. (2012) · Colloquium Series on The Developing Brain · doi:10.4199/c00069ed1v01y201211dbr009 · Cited by 8
Is Adolescence a Sensitive Period for the Development of Incentive-Reward Motivation?
Luciana, M., & Collins, P. F. (2021) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2021_275 · Cited by 7
The developing mouse dopaminergic system: Cortical-subcortical shift in D1/D2 receptor balance and increasing regional differentiation
Bjerke, I. E., Carey, H., Bjaalie, J. G., Leergaard, T. B., & Kim, J. H. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105899 · Cited by 7
Perinatal activation of ERα and ERβ but not GPER-1 masculinizes female rat caudate-putamen medium spiny neuron electrophysiological properties
Cao, J., & Meitzen, J. (2021) · Journal of Neurophysiology · doi:10.1152/jn.00063.2021 · Cited by 7
Age‐typical changes in neural reward response are moderated by maternal anhedonia
Luking, K. R., Infantolino, Z. P., Nelson, B. D., & Hajcak, G. (2019) · Psychophysiology · doi:10.1111/psyp.13358 · Cited by 7
Integration of Developmental Neuroscience and Contextual Approaches to the Study of Adolescent Psychopathology
Monahan, K. C., Guyer, A. E., Silk, J. S., Doremus‐Fitzwater, T. L., & Steinberg, L. D. (2016) · Wiley eBooks · doi:10.1002/9781119125556.devpsy219 · Cited by 7
The influence of social motivation on neural correlates of cognitive control in girls
Barker, T. V., Buzzell, G. A., Troller‐Renfree, S. V., Bowman, L. C., Pine, D. S., & Fox, N. A. (2021) · Developmental Psychobiology · doi:10.1002/dev.22086 · Cited by 5
Dopaminergic system and its relationship with the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-thyroid systems (review)
Molodovskaya, I. N. (2020) · Сибирский научный медицинский журнал · doi:10.15372/ssmj20200604 · Cited by 7
The Anatomical, Hormonal and Neurochemical Changes that Occur During Brain Development in Adolescents and Young Adults
Colver, A., & Dovey‐Pearce, G. (2018) · Springer eBooks · doi:10.1007/978-3-319-72868-1_2 · Cited by 6
Early and transitory hypoactivity and olfactory alterations after chronic atrazine exposure in female Sprague-Dawley rats
Sánchez-Yépez, J., Acevedo-Huergo, T., Mendoza-Trejo, M. S., Corona, R., Hernández-Plata, I., Viñuela‐Berni, V., Giòrdano, M., & Rodríguez, V. M. (2024) · NeuroToxicology · doi:10.1016/j.neuro.2024.01.004 · Cited by 5
The neural basis of puberty and
Sisk, A. L., & Foster, D. L. (2004) · Cited by 4
Developmental changes in reward processing are reward specificPreprint
Veselič, S., Smid, C. R., & Steinbeis, N. (2021) · doi:10.31234/osf.io/fzk9t · Cited by 4
Immune signaling in sex-specific neural and behavioral development: Adolescent opportunity
King’uyu, D. N., Stephens, S. B. Z., & Kopec, A. M. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102647 · Cited by 3
Le développement du cerveau et les patterns de conduites typiques pendant l’adolescence (1re partie)
SPEAR, L. P. (2008) · PSN · doi:10.1007/s11836-008-0068-9 · Cited by 4
Within versus between group designs, and not timing of onset of puberty, influence sex and age differences in intake of palatable food in rats
Murray, S. H., & McCormick, C. M. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113997 · Cited by 3
The relationship between puberty and social emotion processing
Goddings, A., Heyes, S. B., Klapwijk, E. T., Bird, G., Viner, R., & Blakemore, S. (2012) · Archives of Disease in Childhood · doi:10.1136/archdischild-2012-301885.151 · Cited by 3
Reduced sensitivity to cocaine effects and changes in mesocorticolimbic dopamine receptors in adolescent sexually active female rats
Agrati, D., Marín, G., Rehermann, L., Uriarte, N., Antonelli, M. C., & Bedó, G. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06741-3 · Cited by 1
Children and adults differ in how primary and secondary incentives modulate valuation, effort, and cognitive control
Veselič, S., Smid, C. R., Beveridge, F., & Steinbeis, N. (2026) · PLoS ONE · doi:10.1371/journal.pone.0351143 · Cited by 1
Neuro-bio-chemical balance within deviant delinquent behaviors in adolescents
Damian, S.-I., Șchiopu, C. G., Dobrin, R., Boloș, A., & Ștefănescu, C. (2022) · Bulletin of Integrative Psychiatry · doi:10.36219/bpi.2022.1.07 · Cited by 2
Effects of Peripubertal Experiences on Competitive Behavior in Male Rats at Different Stages of Adulthood
Huang, J. H. J., Yang, W., Bao, L., & Yin, B. (2024) · Developmental Psychobiology · doi:10.1002/dev.22544 · Cited by 1
An Analysis of the Interaction of Methylphenidate and Nicotine in Adolescent Rats: Effects on BDNF
Freeman, E. D. (2015) · Digital Commons - East Tennessee State University (East Tennessee State University) · Cited by 1
The Developing Nucleus Accumbens Septi: Susceptibility to Alcohol's Effects
Philpot, R. M. (2004) · Digital Commons - University of South Florida (University of South Florida)
Developmental differences in locomotor responsiveness to amphetamine in rats
Mathews, I. Z. (2011) · Brock University Digital Repository (Brock University)
Sex Steroids and Gene Variants in Bipolar Disorder
Johansson, A. G. M. (2012) · Figshare
Interactions of the Striatal Gene Rhes with the Dopaminergic System in Rodents
Garzola, G. C. Q. (2007) · ScholarWorks @ The University of New Orleans (The University of New Orleans)
Exploring the Distribution and Potential Roles of the Developmental Transcription Factor Zic2 in an Adult Protogynous Teleost, Thalassoma bifasciatum
McCaffrey, K. A. (2010) · NCSU Libraries Repository (North Carolina State University Libraries)
Reward Processing and Risk for Depression Across
Pagliaccio, D., & Luby, J. L. (2016)
Stress responding in periadolescent rats exposed to cat odour and long-term outcomes for stress-related aspects of the adult phenotype
Wright, L. (2011) · Library and Archives Canada (Government of Canada)
Sex differences in PFC-related behavior after amphetamine exposure and across adolescent development
Hammerslag, L. R. (2017) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Effects of Unpredictable Chronic Mild Stress on Adolescent Rats
Kirschmann, E. K. (2014) · D-Scholarship@Pitt (University of Pittsburgh)
Le développement du cerveau et les patterns de conduites typiques pendant l’adolescence (2e partie)
SPEAR, L. P. (2008) · PSN · doi:10.1007/s11836-008-0070-2
Efeito do canabidiol sobre as consequências da exposição ao isolamento social prolongado em camundongos fêmeas em diferentes idades: possível envolvimento da via do inflamassoma de NLRP3
Bilibio, J. O. (2024) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2024.tde-13052024-160023
Nandrolone alters the behavioral response to cocaine as well as striatal and cortical dopamine receptors of prepubertal male rats
Freire, J. A., Rivero, C. J., Santiago-Marrero, I. G., Mendez-Morales, A., González-Segarra, A. J., Pérez‐Cardona, E. U., Torres-Ramirez, R. J., & Segarra, A. C. (2025) · Scientific Reports · doi:10.1038/s41598-025-17890-6
Alimentation durant l'adolescence : facteurs de troubles comportementaux et neurobiologiques à l'âge adulte : modèle animal chez le rat
Gueye, A. B. (2010) · theses.fr (ABES) · doi:10.70675/348ce609z5924z4ab5z9f76z80c1ef13a725
Puberty, not age, marks the start of adolescent brain structural remodeling
Chad, J. A., Klukas, O. C., Ghasoub, M., & Lebel, C. A. (2026) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2026.101835
Developmental disruption of the mediodorsal thalamus alters prefrontal dopamine D2 receptor expression and prefrontal–accumbal neuronal recruitment during latent inhibition
Ouhaz, Z., Daoudi, H. I., Darfaoui, M., Tait, D. S., Moubarrad, F.-Z. L., Ba-M’hamed, S., Nejmeddine, M., & Bennis, M. (2026) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2026.1998199
Attenuated Cocaine Seeking After Adolescent-Onset of Cocaine Self-Administration in Male Rats: Behavior, Environment, and Genes
Li, C. (2011) · Digital Archive @ GSU · doi:10.57709/2102125

Authors: Andersen, S.
Affiliations: Harvard University (US)
Corresponding author: Andersen, S
ORCID: Andersen, S
Venue: Psychoneuroendocrinology
Publisher: Elsevier BV
Published: 2002-08
Volume: 27
Issue: 6
Pages: 683-691
ISSN: 0306-4530 (ISSN-L)
DOI: 10.1016/s0306-4530(01)00069-5
OpenAlex: W2041464048
Cited by: 152
References: 27
Citations by year: 2026: 3 · 2025: 1 · 2024: 5 · 2022: 12 · 2021: 7 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 10 · 2015: 6 · 2014: 6 · 2013: 10 · 2012: 10
FWCI: 2.79
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Psychoneuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Tourette Association of America
National Institute of Mental Health (NIMH-43473)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords: puberty, gonadal hormones, dopamine receptors, dopamine D1 receptor, dopamine D2 receptor, striatum, castration, ovariectomy, testosterone, estrogen, sex differences, adolescence, early adulthood, receptor density
MeSH terms: Aging, Animals, Autoradiography, Corpus Striatum, Estrogens, Female, Male, Orchiectomy, Ovariectomy, Receptors, Dopamine, Sex Characteristics, Sexual Maturation, Testosterone, Rats, Sprague-Dawley, Receptors, Dopamine D1, Receptors, Dopamine D2, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pubertal changes in gonadal hormones do not underlie adolescent dopamine receptor overproduction

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks