Cited by 16Hypothalamic control of reproductive hormonesNeuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Immune signaling as a node of interaction between systems that sex-specifically develop during puberty and adolescence

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Granata, Lauren, Gildawie, Kelsea R., Ismail, Nafissa, Brenhouse, Heather C., Kopec, Ashley M.·2022·Developmental Cognitive Neuroscience

Abstract

Adolescence is pivotal for neural and behavioral development across species. During this period, maturation occurs in several biological systems, the most well-recognized being activation of the hypothalamic-pituitary-gonadal axis marking pubertal onset. Increasing comparative studies of sex differences have enriched our understanding of systems integration during neurodevelopment. In recent years, immune signaling has emerged as a key node of interaction between a variety of biological signaling processes. Herein, we review the age- and sex-specific changes that occur in neural, hypothalamic-pituitary, and microbiome systems during adolescence. We then describe how immune signaling interacts with these systems, and review recent preclinical evidence indicating that immune signaling may play a central role in integrating changes in their typical and atypical development during adolescence. Finally, we discuss the translational relevance of these preclinical studies to human health and wellness.

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Authors
Granata, L., Gildawie, K. R., Ismail, N., Brenhouse, H. C., & Kopec, A. M.
Affiliations
  • Northeastern University (US)
  • Tufts University (US)
  • University of Ottawa (CA)
  • Albany Medical College (US)
Corresponding author
Kopec, Ashley M.
Venue
Developmental Cognitive Neuroscience
Publisher
Elsevier BV
Published
2022-10
Volume
57
Pages
101143
ISSN
1878-9293 (ISSN-L)
OpenAlex
W4289527871
Cited by
15
References
300
Citations by year
2026: 2 · 2025: 5 · 2024: 2 · 2023: 6
FWCI
2.74
Type
journal article
Language
en
Open access
Locations
  • Developmental Cognitive Neuroscience (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health (R03AG07011)
  • Natural Sciences and Engineering Research Council of Canada
  • National Institute on Aging (R03AG070111)
  • National Institute of Mental Health (R01MH127850)
  • National Institute on Drug Abuse (R01DA052889)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
immune signaling, adolescence, puberty, sex differences, hypothalamic-pituitary-gonadal axis, microbiome, brain development, system integration, hypothalamic-pituitary axis, atypical development

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