Immune signaling as a node of interaction between systems that sex-specifically develop during puberty and adolescence
Open accessAbstract
Adolescence is pivotal for neural and behavioral development across species. During this period, maturation occurs in several biological systems, the most well-recognized being activation of the hypothalamic-pituitary-gonadal axis marking pubertal onset. Increasing comparative studies of sex differences have enriched our understanding of systems integration during neurodevelopment. In recent years, immune signaling has emerged as a key node of interaction between a variety of biological signaling processes. Herein, we review the age- and sex-specific changes that occur in neural, hypothalamic-pituitary, and microbiome systems during adolescence. We then describe how immune signaling interacts with these systems, and review recent preclinical evidence indicating that immune signaling may play a central role in integrating changes in their typical and atypical development during adolescence. Finally, we discuss the translational relevance of these preclinical studies to human health and wellness.
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Adolescence is evolutionarily conserved, with animal species also showing distinct markers of an adolescent state.
“it is increasingly recognized to be evolutionarily conserved, with animal species also showing distinct markers of an adolescent state [35–40].”
From Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks (2025) · cites this paper as [37]
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Amphetamine disrupts dopamine axon growth in adolescence by a sex-specific mechanism in mice
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- Authors
- Granata, L., Gildawie, K. R., Ismail, N., Brenhouse, H. C., & Kopec, A. M.
- Affiliations
- Northeastern University (US)
- Tufts University (US)
- University of Ottawa (CA)
- Albany Medical College (US)
- Corresponding author
- Kopec, Ashley M.
- Venue
- Developmental Cognitive Neuroscience
- Publisher
- Elsevier BV
- Published
- 2022-10
- Volume
- 57
- Pages
- 101143
- ISSN
- 1878-9293 (ISSN-L)
- PMC
- PMC9357835
- OpenAlex
- W4289527871
- Cited by
- 15
- References
- 300
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 6
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Developmental Cognitive Neuroscience (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (R03AG07011)
- Natural Sciences and Engineering Research Council of Canada
- National Institute on Aging (R03AG070111)
- National Institute of Mental Health (R01MH127850)
- National Institute on Drug Abuse (R01DA052889)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- immune signaling, adolescence, puberty, sex differences, hypothalamic-pituitary-gonadal axis, microbiome, brain development, system integration, hypothalamic-pituitary axis, atypical development
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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