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Pubertal changes in gonadal hormones do not underlie adolescent dopamine receptor overproduction
Abstract
Males, but not females, overproduce dopamine receptors in the striatum of rats across the periadolescent period followed by their elimination during young adulthood. In order to investigate the role that gonadal hormones play in this pubertal process, rats were castrated or ovariectomized at postnatal day (P) 28 when estrogen and testosterone levels are beginning to surge. Dopamine D1 and D2 striatal receptor density was then determined with autoradiography at P40 (adolescence) and P80 (young adulthood) to determine if either testosterone stimulates the overproduction of receptors in males or if estrogen inhibits this process in females. Neither castration nor ovariectomy altered dopamine receptor density, although enhanced testosterone levels increased D1 receptor binding 4.2% and 19.5% in males and females, respectively. The results of this study suggest that the endogenous rise in gonadal steroid hormones during puberty is not responsible for the overproduction of receptors in males or the lack of overproduction in females.
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“For example, castration or testosterone injections during mid to late adolescence (p45-p60) alter various markers of dopaminergic function in male rats (Purves-Tyson et al., 2014), though gonadal hormones are not necessary for male-specific peaks in striatal dopamine receptor expression (Andersen et al., 2002).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Andersen et al., 2002
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Metadata
- Authors
- Andersen, S.
- Affiliations
- Harvard University (US)
- Corresponding author
- Andersen, S
- ORCID
- Andersen, S
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 27
- Issue
- 6
- Pages
- 683-691
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2041464048
- Cited by
- 152
- References
- 27
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 5 · 2022: 12 · 2021: 7 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 10 · 2015: 6 · 2014: 6 · 2013: 10 · 2012: 10
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Tourette Association of America
- National Institute of Mental Health (NIMH-43473)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Keywords
- puberty, gonadal hormones, dopamine receptors, dopamine D1 receptor, dopamine D2 receptor, striatum, castration, ovariectomy, testosterone, estrogen, sex differences, adolescence, early adulthood, receptor density
- MeSH terms
- Aging, Animals, Autoradiography, Corpus Striatum, Estrogens, Female, Male, Orchiectomy, Ovariectomy, Receptors, Dopamine, Sex Characteristics, Sexual Maturation, Testosterone, Rats, Sprague-Dawley, Receptors, Dopamine D1, Receptors, Dopamine D2, Rats
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