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Cited by 155Smoking Behavior and CessationSubstance Abuse Treatment and OutcomesPrenatal Substance Exposure Effects

The DOI matches its Crossref record; 17 of the 18 references it cites were found in a registry or an index.

Mediating mechanisms for the impact of bupropion in smoking cessation treatment

Lerman, Caryn, Roth, David, Kaufmann, Vyga, Audrain, Janet, Hawk, Larry, Liu, Aiyi, Niaura, Ray, Epstein, Leonard·2002·Drug and Alcohol Dependence
DOI 10.1016/s0376-8716(02)00067-4
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Abstract

Several studies have documented the effectiveness of bupropion for smoking cessation, yet little is known about the mechanisms by which it facilitates abstinence. In this placebo-controlled randomized trial. We examined whether bupropion's effects on cessation were mediated by changes in withdrawal and/or negative or positive affect (PA). Two hundred and fifty-one smokers received 10-week treatment with bupropion or placebo, plus behavioral counseling. Changes in affect and withdrawal symptoms from pre-quit to 1 week post quit were examined as mediating variables in structural equation models. Cotinine-verified 7-day point prevalence cessation rates at the end of treatment (8-weeks post quit date) were 48% for bupropion and 29% for placebo (P=0.001). There were significant treatment effects on withdrawal and negative affect (NA); however, only change in NA predicted cessation. In a path model, change in NA was a significant mediator of bupropion's effects on cessation. However, the proportion of variance accounted for by this mediator was small, suggesting that other unmeasured factors play an important role. Laboratory-based paradigms may be useful to identify other mediators of bupropion's effects, thereby pointing to mechanisms of effect that can be bolstered in future treatment studies.

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Crossref · 10.1016/s0376-8716(02)00067-4

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Metadata

Authors
Lerman, C., Roth, D., Kaufmann, V., Audrain, J., Hawk, L., Liu, A., Niaura, R., & Epstein, L.
Affiliations
  • University of Pennsylvania Health System (US)
  • University of Alabama at Birmingham (US)
  • State University of New York (US)
  • Georgetown University (US)
  • University at Buffalo, State University of New York (US)
Corresponding author
Lerman, Caryn
ORCID
Venue
Drug and Alcohol Dependence
Publisher
Elsevier BV
Published
2002-07
Volume
67
Issue
2
Pages
219-223
ISSN
0376-8716 (ISSN-L)
DOI
10.1016/s0376-8716(02)00067-4
OpenAlex
W2081438909
Cited by
155
References
18
Citations by year
2026: 2 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 4 · 2016: 6 · 2015: 8 · 2014: 3 · 2013: 8 · 2012: 3
FWCI
6.79
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Drug and Alcohol Dependence (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (P50CA084718, R01CA63562, P50-CA84718, R01CA063562)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords
bupropion, smoking cessation, nicotine withdrawal symptoms, negative affect, positive affect, mediation analysis, behavioral counseling, nicotine dependence, abstinence
MeSH terms
Adult, Aged, Analysis of Variance, Female, Humans, Male, Middle Aged, Smoking, Smoking Cessation, Bupropion, Treatment Outcome

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